Pheochromocytoma

Bravo, Emmanuel L.

doi:10.1111/j.1749-6632.2002.tb04408.x

Cited by 68 publications

(10 citation statements)

References 25 publications

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“…Our aim was to analyze the effects of long-term pesticide exposure on NTs and their precursor metabolites. Studies have linked the concentration of NTs in biological fluids to various diseases, including cancerous tumors, neuroblastoma, and pheochromocytoma, common tumors in children with higher catecholamine levels in the blood and urine, as these are well-known biomarkers for diagnosing the disease and keeping an eye on treatment. In our study, it was found that blood levels of the NTs dopamine, serotonin, and norepinephrine were significantly higher in the unexposed group, as were levels of the metabolites DOPAC, 5-HIAA, and 3-MT.…”

Section: Resultsmentioning

confidence: 99%

Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples

Kumar,

Sinha,

Gouda

2024

J. Am. Soc. Mass Spectrom.

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For the simultaneous determination of monoamine neurotransmitters (NTs) like dopamine, serotonin, noradrenaline, and epinephrine, and their metabolites (metanephrine, normetanephrine, 3-methoxytyramine, vanillylmandelic acid, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindoleacetic acid), a robust liquid chromatography method coupled with tandem mass spectrometry (LC–MS/MS) was introduced as the analytical method. This analytical method proved to be accurate for the simultaneous measurement of the amounts of 11 NTs and their metabolites in biological samples. The method proved to be more efficient and better than the previously reported method in terms of precision, recovery, sample requirement, and extraction procedure. The reported method requires only 100 μL of blood and 200 μL of urine, and the extraction procedure requires acetonitrile precipitation, filtration, drying, and reconstitution in water. The separation of all analytes was performed on an C18 column (4.6 mm × 150 mm and 1.8 μm). A 10 min gradient elution program with a mobile phase consisting of phase A (0.2% formic acid in water) and phase B (methanol) was used. The positive ionization mode was used for the detection of all analytes in multiple reaction monitoring (MRM). The proposed method was validated with an internal standard and yielded lower limits of detection and quantification ranges of 0.0182–0.0797 ng/mL and 0.0553–0.2415 ng/mL, respectively, with a good linearity (R 2) between 0.9959 and 0.9994. The recoveries ranged from 73.37% to 116.63% in blood and from 80.9% to 115.33% in urine. For the NTs and metabolites, the intra- and interday % CV were 0.24–9.36 and 0.85–9.67, respectively. The developed LC–MS/MS method was successfully used for the determination of trace amounts of endogenous compounds in human blood and urine samples.

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Section: Resultsmentioning

confidence: 99%

Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples

Kumar,

Sinha,

Gouda

2024

J. Am. Soc. Mass Spectrom.

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“…At higher doses, esmolol inhibits β 2 -adrenoceptors located in the musculature of bronchi and blood vessels. Moreover, as patients’ oral intake improves, cardio-selective β 1 -adrenoceptor blockers such as metoprolol (Lopressor) 25–50 mg three to four times a day or atenolol (Tenormin) 12.5–25 mg once a day (occasionally twice daily) orally are also administered to control catecholamines or α-adrenoceptor blocker induced tachyarrhythmia [33,34].…”

Section: Cardiovascular Complications Related To Ppglsmentioning

confidence: 99%

Postoperative Management in Patients with Pheochromocytoma and Paraganglioma

Mamilla

Araque

Brofferio

et al. 2019

Cancers

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Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-secreting neuroendocrine tumors of the adrenal medulla and sympathetic/parasympathetic ganglion cells, respectively. Excessive release of catecholamines leads to episodic symptoms and signs of PPGL, which include hypertension, headache, palpitations, and diaphoresis. Intraoperatively, large amounts of catecholamines are released into the bloodstream through handling and manipulation of the tumor(s). In contrast, there could also be an abrupt decline in catecholamine levels after tumor resection. Because of such binary manifestations of PPGL, patients may develop perplexing and substantially devastating cardiovascular complications during the perioperative period. These complications include hypertension, hypotension, arrhythmias, myocardial infarction, heart failure, and cerebrovascular accident. Other complications seen in the postoperative period include fever, hypoglycemia, cortisol deficiency, urinary retention, etc. In the interest of safe patient care, such emergencies require precise diagnosis and treatment. Surgeons, anesthesiologists, and intensivists must be aware of the clinical manifestations and complications associated with a sudden increase or decrease in catecholamine levels and should work closely together to be able to provide appropriate management to minimize morbidity and mortality associated with PPGLs.

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“…The preferential treatment is surgery, whose preoperative preparation should include alpha1-blockers (doxazosin or prazosin) and appropriate hydration for at least 2 weeks before surgery. 52 The chronic pharmacological treatment includes alpha1-blockers, BBs (only after beginning alpha1-blockers, in the presence of symptomatic tachycardia), CCBs, ACEIs and central action agonists. 52 The paroxysmal HC of PHEO is a HE, and should be treated with SNP or injectable phentolamine and volume replacement, if necessary.…”

Section: Introductionmentioning

confidence: 99%

“… 52 The chronic pharmacological treatment includes alpha1-blockers, BBs (only after beginning alpha1-blockers, in the presence of symptomatic tachycardia), CCBs, ACEIs and central action agonists. 52 The paroxysmal HC of PHEO is a HE, and should be treated with SNP or injectable phentolamine and volume replacement, if necessary. 46 …”

Section: Introductionmentioning

confidence: 99%