Philadelphia-Chromosom und alkalische Leukocyten-Phosphatase bei chronischer Myelose

The Enzymes of the Granules of Polymorphonuclear Leukocytes and Their Functions

“…It has been shown (only a few recent and fairly representative references are given) that its activity is increased in bacterial (but not in viral) infections [143,144], in osteomyelofibrosis, in polycythemia vera and in some other leukocytic disorders [145,146], and in mongolism [147,148]. In chronic myeloid leukemia [144][145][146]149], the PMN alkaline phosphatase is low. Many factors influencing the enzyme activity have been described [145].…”

“…Many factors influencing the enzyme activity have been described [145]. The relationship between PMN alkaline phos phatase and chromosome 21, which is abnormal in both mongolism and myeloid leukemia, has been studied extensively [148][149][150]. A detailed enzymological study of alkaline phosphatase from PMN of normal individuals, as well as of patients with myeloid leukemia, and of reactive granulocytosis shows that despite marked differences in specific activity, many of the pro perties of the enzyme remain unchanged [144].…”

The phosphatases of peripheral white blood cells in workers exposed to trichloroethylene and perchloroethylene

“…depends upon, among other things, heredity factors (Santachiara-Benerecetti, Cesari, and De Carli, 1967;Winkelstein, Goldberg, Tishkoff, and Sparkes, 1967;Gropp, Fischer, Niederalt, Klesse, and Hensen, 1968), pathological conditions, e.g., hypophosphataemia (Beisel, Benjamin, and Austen, 1959), the excretory system (Griffin and Cox, 1966;Rosner and Lee, 1965), and the relationship between serum and leucocyte alkaline phosphatases (Lohmann and Weissel, 1964). Many papers have dealt with L.A.P.…”