This paper combines Simondon’s philosophy of individuation with some aspects of post-humanist and‘new materialist’ thought, while, at the same time, remaining within the ambit of a more classically ‘historical’characterisation of materialism. Two keywords drawn from Karen Barad and Simondon respectively – ‘ontoepistemology’and ‘axiontology’ – represent the red thread of a narrative that connects the early modern invention of civil science(emblematically represented here by the conceptual couple Descartes-Hobbes) to Wiener’s cybernetic theory ofsociety. The political stakes common to these forms of what I call ‘banal’ materialism, Simondon attacked ontologically,epistemologically and politically. The conceptual tools Simondon’s philosophy of individuation elaborates prove tosupport a ‘non-banal’ materialist critique of the alleged ‘unsocial sociability’ of human nature theorised in modernpolitical theory. A genuine materialist approach, as I will argue, allows us to shift political thinking from politicsconceived as a problem to be solved to politics as an arena of strategic experimentation.