Phloroglucinol-Combined Photobiomodulation for Minimizing Burn-Induced Skin Fibrosis

Combinatorial prophylactic effect of phlorotannins with photobiomodulation against tracheal stenosis

“… 27 , 28 , 29 In our previous studies, PT isolated from Ecklonia cava showed inhibitory activity against fibrotic response through in vitro , in vivo , and in silico analyses. 16 , 27 , 30 Recent studies have reported the anti-fibrotic effects of nintedanib and pirfenidone, whereas various side effects such as diarrhea, fatigue, skin-related events, and decreased appetite have been reported. 4 , 14 , 15 Unlike synthetic drugs, PT from natural products has the advantage of minimal or no sideeffects.…”

“…For clinical application, further in vivo tests are necessary to determine the optimal timing and frequency of treatment and to verify the therapeutic and sideeffects in the long-term application of the porcine model, which is similar to the human skin anatomically and physiologically. 30 , 42 Further studies will be conducted to elucidate several unproven factors that have not been validated in this study to improve the efficiency of the proposed treatment.…”