Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ

Extraction and Identification of Phlorotannins from the Brown Alga, Sargassum fusiforme (Harvey) Setchell

“…The highest level of TPC was found in the ethyl acetate fraction with a value of 88.48 ± 0.30 mg PGE/100 mg, which was dramatically higher than that in 1-butanol fraction and aqueous residue whose TPC values was at 20.67 ± 0.08 and 6.96 ± 0.02 mg PGE/100 mg, respectively. Ethyl acetate has been widely used to selectively extract polyphenolic compounds from various seaweeds [8,23,24,25,26,27,28]. TPC in the ethyl acetate fraction of S. fusiforme was similar to that of Fucus vesiculosus (88.3 ± 2.2 mg PGE/100 mg) reported by Wang et al [1], but dramatically higher than that of many other species including Eisenia bicyclis [29,30,31], Ecklonia maxima [32], and S. muticum [4].…”

Red and green macroalgae for fish and animal feed and human functional food development

“…These phlorotannins showed potent, free radical scavenging activity, which was quantified to be around twice as effective as the known anti-oxidants catechin, ascorbic acid and α-tocopherol (40) . Several phlorotannins purified from brown seaweeds have shown medicinal and pharmaceutical benefits and have shown strong anti-oxidant, anti-inflammatory, anti-hepatotoxic, anti-allergic, anti-hypertensive, cosmetic (skin whitening effect), anti-adipogenic, anti-viral, anti-tumor, anti-diabetes and anticancer properties (41) . Also, phlorotannins have shown anti-bacterial activity previously (42) ; thus, it is thought that phlorotannins from brown algae could be very useful in the food and pharmaceutical industries as alternative food preservative agents and anti-biotic agents (42) .…”

Anti-proliferative activity and chemical characterization by comprehensive two-dimensional liquid chromatography coupled to mass spectrometry of phlorotannins from the brown macroalga Sargassum muticum collected on North-Atlantic coasts

“…This particular type of polyphenols comprises a very heterogeneous group of polymeric compounds with a great chemical variability [2]. The interest of these compounds is related to their associated bioactivities, such as antioxidant [3][4][5], anti-inflammatory [6], anti-bacterial [7,8], antidiabetic [9] or anti-adipogenic [10], among others. Moreover, their potential anti-proliferative activity has approaches have been attempted for the structural elucidation of phlorotannins in their native form; for instance, Stiger-Pouvreau et al [15] employed one-and two-dimensional nuclear magnetic resonance (NMR) (1H, heteronuclear multiple bond correlation) together with in vivo NMR (high-resolution magic-angle spinning, HR-MAS NMR) analyses, to structurally elucidate and fingerprint phlorotannin signals in different Sargassaceae species.…”