Phonon-mediated lipid raft formation in biological membranes

Bolmatov, Dima; Kinnun, Jacob J.; Katsaras, John; Lavrentovich, Maxim O.

doi:10.1016/j.chemphyslip.2020.104979

Cited by 12 publications

(10 citation statements)

References 99 publications

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“…Figure 3a shows the IXS scattering geometry of the DPPC bilayer. In IXS experiments, 94 an incident X-ray beam of energy E i and momentum k i − ℏ = 1 − scatters away with energy E f and momentum k f mainly due to interactions with electrons (see Figure 3a). Importantly, phonon excitations originate from thermally triggered density−density fluctuations.…”

Section: Biological Fluidsmentioning

confidence: 99%

“…Importantly, phonon excitations originate from thermally triggered density−density fluctuations. As a result, the scattered beam carries information on phonons corresponding to the scanned energy transfer 94 Furthermore, IXS phonon spectra and their spectral lineshapes (see Figure 3b,c) can be fitted utilizing the damped harmonic oscillator (DHO) model given by…”

Section: Biological Fluidsmentioning

confidence: 99%

“…where E j is the average excitation energy, A j (Q) the amplitude of a single inelastic (E j ≠ 0) phonon excitation, and Γ j (Q) the half-width at half-maximum of a vibrational peak. 94 Each selected IXS spectrum has a specific number of vibrational peaks within a scanned energy range. In panels b and c of Figure 3 are IXS spectra at Q = 3.89 nm −1 of the DPPC bilayer in the gel phase at 20 °C and in the fluid phase at 45 °C, respectively.…”

Section: Biological Fluidsmentioning

confidence: 99%

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The Phonon Theory of Liquids and Biological Fluids: Developments and Applications

Bolmatov

2022

J. Phys. Chem. Lett.

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Among the three basic states of matter (solid, liquid, and gas), the liquid state has always eluded general theoretical approaches for describing liquid energy and heat capacity. In this Viewpoint, we derive the phonon theory of liquids and biological fluids stemming from Frenkel’s microscopic picture of the liquid state. Specifically, the theory predicts the existence of phonon gaps in vibrational spectra of liquids and a thermodynamic boundary in the supercritical state. Direct experimental evidence reaffirming these theoretical predictions was achieved through a combination of techniques using static compression X-ray diffraction and inelastic X-ray scattering on deeply supercritical argon in a diamond anvil cell. Furthermore, these findings inspired and then led to the discovery of phonon gaps in liquid crystals (mesogens), block copolymers, and biological membranes. Importantly, phonon gaps define viscoelastic crossovers in cellular membranes responsible for lipid self-diffusion, lateral molecular-level stress propagation, and passive transmembrane transport of small molecules and solutes. Finally, molecular interactions mediated by external stimuli result in synaptic activity controlling biological membranes’ plasticity resulting in learning and memory. Therefore, we also discuss learning and memory effectsequally important for neuroscience as well as for the development of neuromorphic devicesfacilitated in biological membranes by external stimuli.

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Section: Biological Fluidsmentioning

confidence: 99%

Section: Biological Fluidsmentioning

confidence: 99%

Section: Biological Fluidsmentioning

confidence: 99%

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The Phonon Theory of Liquids and Biological Fluids: Developments and Applications

Bolmatov

2022

J. Phys. Chem. Lett.

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“…15,17,[49][50][51][52][53]55,56 Indeed, the plasma membrane is thought to consist of many different raft-like and non-raft-like regions of varying lipid composition. 6,10,53 These raft-like regions may arise through many different physical processes, 9,57,58 with different physical mechanisms dominating at different stages 3 . CC-BY 4.0 International license available under a was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.…”

mentioning

confidence: 99%

“…17,49–56 Indeed, the plasma membrane is thought to consist of many different raft-like and non-raft-like regions of varying lipid composition. 6,10,53 These raft-like regions may arise through many different physical processes, 9,57,58 with different physical mechanisms dominating at different stages of domain formation. 59 Given the complexity of the plasma membrane, model membranes are typically employed for the study of domain formation.…”

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confidence: 99%

Cholesterol Oxidation Modulates the Formation of Liquid-Ordered Domains in Model Membranes

Smith

Petrov

Lorenz

2021

Preprint

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7-ketocholesterol (KChol) is one of the most cytotoxic oxysterols found in the plasma membrane, and increased levels of KChol are associated with numerous pathologies. It is thought to induce apoptosis via inactivation of the phosphatidylinositol 3-kinase/Akt signaling pathway - a pathway that depends on lipid-rafts as signaling platforms. By means of coarse-grained molecular dynamics simulations, we demonstrate that KChol disrupts the liquid-liquid phase separation seen in an equimolar mixture of (dipalmitoylphosphatidylcholine) DPPC, (dioleoylphosphatidylcholine) DOPC, and Cholesterol (Chol). This disruption occurs via two mechanisms: i) KChol adopts a wider range of orientations with the membrane, which disrupts the packing of neighboring lipids and ii) KChol has no preference for DPPC over DOPC, which is the main driving force for lateral demixing in DPPC/DOPC/Chol membranes. This provides a molecular description of the means by which KChol induces apoptosis, and illustrates that a single chemical substitution to cholesterol can have a profound impact on the lateral organization of lipid membranes.

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