Roles of interfacial water states on advanced biomedical material design

Nishida, Kei; Anada, Takahisa; Tanaka, Masaru

doi:10.1016/j.addr.2022.114310

Cited by 26 publications

(29 citation statements)

References 243 publications

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“…These interacting water molecules are believed to be actively involved in the prevention of platelet adhesion and the adsorption and denaturation of related serum proteins. [ 18–23 ] Compared to the results in previous reports, [ 24,25 ] the exotherm at ≈−40 °C in the cooling scan appeared to reflect the water interacting with methoxy side groups. Those at ≈−25 °C may correspond to water interacting with ether bonds in the main chain and ester groups in the main and side chains (Figure 6b).…”

Section: Resultsmentioning

confidence: 52%

“…The equilibrium water content (EWC) was calculated from the difference in sample weights in the hydrated and dry states. [ 18–22 ] The EWC of 1 was 6–7 wt%, which is higher than those of the ether‐bearing aliphatic polycarbonates previously developed (≈5 wt%) [ 24,25 ] but lower than that of PDX (≈10 wt%). [ 32 ] The number of water molecules per repeating unit ( n w ) of polymer 1 , PDX, and PMEMTC were calculated from the EWC and molecular weights of the repeating units of the polymers, to be 0.81, 0.63, and 0.62, respectively (Supporting Information).…”

Section: Resultsmentioning

confidence: 94%

“…As mentioned in the Introduction, the blood compatibility of polymers correlates with the hydration properties, [19][20][21] which can be evaluated by differential scanning calorimetry (DSC) and water contact angles. The DSC profiles of polymer 1 showed a glass transition temperature (T g ) of −30 °C in the dry state (Figure 6a).…”

Section: Hydration Properties Of Polymermentioning

confidence: 99%

“…[18,19] The high blood compatibility of these polymers is believed to be related to surface hydration. [20,21] The concept of hydration-driven biocompatibility facilitates recent developments and applications of various etherfunctionalized polymers, [22,23] including aliphatic polycarbonates, mimicking the side-chain structure of PMEA. The polymer poly(2-methoxyethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate) (PMEMTC; Figure 1) [24] exhibited significantly lower platelet adhesion than the non-substituted aliphatic polycarbonate poly(trimethylene carbonate) (PTMC).…”

Section: Introductionmentioning

confidence: 99%

“…[ 18,19 ] The high blood compatibility of these polymers is believed to be related to surface hydration. [ 20,21 ]…”

Section: Introductionmentioning

confidence: 99%

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Polydioxanone Derivative Bearing Methoxy Groups toward Bio‐Functional Degradable Polymers Exhibiting Hydration‐Driven Biocompatibility

Fukushima

Ota

Kato

2022

Macro Chemistry & Physics

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An aliphatic poly(ester-ether) with methoxy side chains from a glycerol derivative that exhibits increased hydration properties for potential applications in blood-contacting medical devices is developed. The poly(ester-ether) is prepared by ring-opening polymerization (ROP) of an analogue of 1,4-dioxan-2-one (DX) with a methoxy-containing substituent in the presence of acidic organocatalysts. It is found that the ring-chain equilibrium resides in the ROP of the DX analogue at room temperature and at relatively low monomer concentration (≈2 m). The organocatalytic ROP has enabled more than 80% monomer conversion at temperatures below 0 °C in the bulk state. The methoxy-bearing poly(ester-ether) is insoluble in water, amorphous, and viscous, demonstrating a high level of interaction with water when evaluating the thermal properties of the hydrated polymer and water contact angles. The polymer also shows susceptibility to hydrolysis and end-group dependence on thermal degradation. These results suggest a good potential for methoxy-bearing poly(ester-ether) as a biodegradable and biocompatible polymer derived from renewable feedstocks.

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Section: Resultsmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 94%

Section: Hydration Properties Of Polymermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[ 18,19 ] The high blood compatibility of these polymers is believed to be related to surface hydration. [ 20,21 ]…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polydioxanone Derivative Bearing Methoxy Groups toward Bio‐Functional Degradable Polymers Exhibiting Hydration‐Driven Biocompatibility

Fukushima

Ota

Kato

2022

Macro Chemistry & Physics

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DPA‐Zinc around Polyplexes Acts Like PEG to Reduce Protein Binding While Targeting Cancer Cells

Nie

You

Zhang

et al. 2023

Adv Healthcare Materials

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Gene therapy holds great promise as an effective treatment for many diseases of genetic origin. Gene therapy works by employing cationic polymers, liposomes, and nanoparticles to condense DNA into polyplexes via electronic interactions. Then, a therapeutic gene is introduced into target cells, thereby restoring or changing cellular function. However, gene transfection efficiency remains low in vivo due to high protein binding, poor targeting ability, and substantial endosomal entrapment. Artificial sheaths containing PEG, anions, or zwitterions can be introduced onto the surface of gene carriers to prevent interaction with proteins; however, they reduce the cellular uptake efficacy, endosomal escape, targeting ability, thereby, lowering gene transfection. Here, it is reported that linking dipicolylamine‐zinc (DPA‐Zn) ions onto polyplex nanoparticles can produce a strong hydration water layer around the polyplex, mimicking the function of PEGylation to reduce protein binding while targeting cancer cells, augmenting cellular uptake and endosomal escape. The polyplexes with a strong hydration water layer on the surface can achieve a high gene transfection even in a 50% serum environment. This strategy provides a new solution for preventing protein adsorption while improving cellular uptake and endosomal escape.

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Fundamentals and Applications of Raman‐Based Techniques for the Design and Development of Active Biomedical Materials

2023

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Raman spectroscopy is an analytical method based on light‐matter interactions that can interrogate the vibrational modes of matter and provide representative molecular fingerprints. Mediated by its label‐free, non‐invasive nature and high molecular specificity, Raman‐based techniques have become ubiquitous tools for in situ characterisation of materials. This review comprehensively describes the theoretical and practical background of Raman spectroscopy and its advanced variants. We highlight the numerous facets of material characterisation that Raman scattering can reveal, including biomolecular identification, solid‐to‐solid phase transitions and spatial mapping of biomolecular species in bioactive materials. The review illustrates the potential of these techniques in the context of active biomedical material design and development by highlighting representative studies from the literature. These studies cover the use of Raman spectroscopy for the characterisation of both natural and synthetic biomaterials, including engineered tissue constructs, biopolymer systems, ceramics and nanoparticle formulations, among others. To increase the accessibility and adoption of these techniques, the present review also provides the reader with practical recommendations on the integration of Raman techniques into the experimental laboratory toolbox. Finally, we provide perspectives on how recent developments in plasmon‐ and coherently‐enhanced Raman spectroscopy can propel Raman from underutilised to critical for biomaterial development.This article is protected by copyright. All rights reserved

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Roles of interfacial water states on advanced biomedical material design

Cited by 26 publications

References 243 publications

Polydioxanone Derivative Bearing Methoxy Groups toward Bio‐Functional Degradable Polymers Exhibiting Hydration‐Driven Biocompatibility

Polydioxanone Derivative Bearing Methoxy Groups toward Bio‐Functional Degradable Polymers Exhibiting Hydration‐Driven Biocompatibility

DPA‐Zinc around Polyplexes Acts Like PEG to Reduce Protein Binding While Targeting Cancer Cells

Fundamentals and Applications of Raman‐Based Techniques for the Design and Development of Active Biomedical Materials

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