Due to the superior hardness and Young's modulus, biocompatibility, optical and fluorescence nanodiamond seems to be outstanding among carbon nanomaterials. In this footpath, the development of diamond nanowires (DNWs) is known to be a significantly innovative field due to their diverse applications such as sensors, semiconductors, and electrochemical utilities. Compared to carbon nanotubes, DNWs theoretically have energetic and mechanically viable structures. However, DNW synthesis in a reproducible way is still a challenging task. In fact, most of the DNWs can be successfully synthesized by chemical vapor deposition (CVD) and reactive-ion etching (RIE) techniques. By contrast, solution-based DNW synthesis has also emerged recently. A detailed study on DNW structures may help the emerging researchers to direct toward diverse applications. In this chapter, we comprehensively presented the up-to-date applications of DNWs along with their synthesis, structures and properties.