Phosphate content affects structure and bioactivity of sol‐gel silicate bioactive glasses

Ting, Hung-Kai; Page, Sam J.; Poologasundarampillai, Gowsihan; Chen, Shu; Yu, Bo; Hanna, John V.; Jones, Julian R.

doi:10.1111/ijag.12322

Cited by 28 publications

(33 citation statements)

References 40 publications

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“…The samples with lower network connectivity are likely to be more reactive upon immersion in SBF in comparison to the other glasses, since the lower network connectivity means a greater population of NBOs to disrupt the silica network, leading to an easier dissolution of glass components. Conversely, increasing the network connectivity increases the chemical durability of the whole structure …”

Section: Resultsmentioning

confidence: 99%

Effects of catalysts on polymerization and microstructure of sol‐gel derived bioglasses

et al. 2018

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This work investigates the effects of the type and concentration of acid catalysts on the microstructural features of silica‐rich bioactive glasses (75Si–16Ca–5Na–4P, in mol%) synthesized from acetate and nitrate precursor salts, using an innovative rapid sol‐gel method, followed by thermal stabilization at 550°C. The results of XRD, SEM, Fourier Transform Infrared Spectrometer (FTIR) and solid state MAS NMR analysis revealed that the lower degrees of polymerization and network connectivity were found for bioglass powders obtained in the presence of high acid concentrations. A low amount of citric acid gave a polymerization degree similar to that obtained in the absence of any catalyst, but the synthesis time was as short as that found for high acid concentrations. The XRD and FTIR results demonstrated amorphous glass powders free of any nitrate by‐products. The microstructure and degree of polymerization could be modified by changing the type and concentration of acid catalyst, enabling one to tailor the bioactivity of glasses even without changing the starting composition.

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Section: Resultsmentioning

confidence: 99%

Effects of catalysts on polymerization and microstructure of sol‐gel derived bioglasses

et al. 2018

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“…The final ADA precipitate was lyophilized and its structure was assessed by FTIR and solid‐state nuclear magnetic resonance (NMR). Besides, its aldehyde group content and oxidation degree were also determined according to the previous methods …”

Section: Methodsmentioning

confidence: 99%

Development of Biocompatible and Antibacterial Collagen Hydrogels via Dialdehyde Polysaccharide Modification and Tetracycline Hydrochloride Loading

Yuan

Yang

et al. 2019

Macro Materials & Eng

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Nowadays, collagen hydrogels with both good physicochemical and antibacterial properties for tissue engineering have drawn broad attention. Herein, a biocompatible and antibacterial collagen hydrogel is developed via alginate dialdehyde (ADA) modification and tetracycline hydrochloride (TC) loading based on Schiff's base formation. Fourier transform infrared spectroscopy and X‐ray diffraction spectra suggest the maintenance of collagen structure integrity after ADA modification. The modification significantly contributes to the improved swelling property, resistance against type I collagenase, and strengthens storage modulus of hydrogels with an increase of ADA concentrations. Meanwhile, dynamic release curves of tetracycline hydrochloride (TC)‐loaded hydrogels describe the burst release at the first 15 min then a gradual release, hydrogels act ideally as carriers in antibacterial activity. Furthermore, in vitro biocompatibility and antibacterial properties are successfully confirmed from the fabricated collagen hydrogels. This physicochemical‐ and antibacterial‐property–improved collagen hydrogel would be a potential candidate for wound healing as a scaffold.

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“…Bioactive glass powders of 60 mol% SiO 2 , 12 mol% P 2 O 5 and 28 mol% CaO composition were prepared through solgel processing route as previously described by Ting et al [21]. All reagents were purchased from Sigma-Aldrich (Dorset, UK).…”

Section: Powder Synthesismentioning

confidence: 99%

“…For this reason BG of various compositions prepared by sol-gel method are often preconditioned prior to cell culture [20]. Recent studies showed that increasing the phosphate content in the sol-gel glass led to formation of a phosphate glass network, which co-exists with the silicate network [21]. Dissolution studies in simulated body fluid (SBF) showed the pH remained neutral but phosphate (apatite) deposition still occurred within 24 h. Therefore, it is hypothesized that the incorporation of phosphate into glass network not only would be an important attributing factor in stabilizing the local pH but also avoids the need for a preconditioning step.…”

Section: Introductionmentioning

confidence: 99%

Long term effects of bioactive glass particulates on dental pulp stem cells in vitro

Gholami¹,

Labbaf²,

Houreh³

et al. 2017

Biomedical Glasses

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Bioactive glasses (BG) are known for their ability to induce bone formation by the action of their dissolution products. Glasses can deliver active ions at a sustained rate, determined by their composition and surface area. Nanoporous sol-gel derived BGs can biodegrade rapidly, which can lead to a detrimental burst release of ions and a pH rise. The addition of phosphate into the glass can buffer the pH during dissolution. Here, dissolution of BG with composition 60 mol% SiO 2 , 28 mol% CaO and 12 mol% P 2 O 5 at 600 µg/ml were investigated. Initially, the dissolution and apatite formation of the BG particulates were examined in simulated body fluid using FTIR and XRD. BG particulates were indirectly exposed to dental pulp stem cells, and the effect of 14 days continuous ion release on human dental pulp stem cells (hDPSC) viability and differentiation was evaluated. Alamar blue assay showed that cell proliferation was not inhibited by the continuous release of Ca, P and soluble silica. In fact, hDPSC in the presence of BG particulate displayed a higher density of mineralized nodules than untreated cells, as assessed by Alizarin red. The results will have a great contribution to the in vivo application of this particular BG.

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Phosphate content affects structure and bioactivity of sol‐gel silicate bioactive glasses

Cited by 28 publications

References 40 publications

Effects of catalysts on polymerization and microstructure of sol‐gel derived bioglasses

Effects of catalysts on polymerization and microstructure of sol‐gel derived bioglasses

Development of Biocompatible and Antibacterial Collagen Hydrogels via Dialdehyde Polysaccharide Modification and Tetracycline Hydrochloride Loading

Long term effects of bioactive glass particulates on dental pulp stem cells in vitro

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