Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5–CaO–Na2O glass system

Ahmed, Ifty; Lewis, Mark P.; Olsen, I; Knowles, Jonathan C.

doi:10.1016/s0142-9612(03)00546-5

Cited by 349 publications

(234 citation statements)

References 15 publications

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Section: Surface Networksupporting

confidence: 89%

“…The same trends were observed in the surfaces and bulk, i.e. an increase in Q 1 and decrease in Q 2 with the increase in Ca 2+ content in the glass (N25 to N20), as reported in theoretical studies of the bulk glass 9,16 , but there is a small drop in Q 1 from N20 to N15, in agreement with experimental findings in the bulk glasses 9,17 .Another distinctive feature in the surfaces is the increase in Q 0 due to the presence of nonconnected phosphates, mainly detected as undercoordinated phosphorus (Figure 4) in melt glasses 16 and appear here during relaxation. In the case of N25 there is also a 1% increase of Q 3 phosphates caused by the formation of ring structures (Figures 4 and 5).…”

supporting

confidence: 89%

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Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

et al. 2017

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This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the author guidelines.Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal's standard Terms & Conditions and the ethical guidelines, outlined in our author and reviewer resource centre, still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. ture at the surface, and how this changes from that of the bulk.In the past few years, our groups and others have extensively used state-of-the-art highperformance computing methods, usually molecular dynamics (MD) simulations, to characterise the structure and properties of PBGs. In molecular dynamics, the individual atoms move due to the interatomic forces they experience from other atoms. Because the full three-dimensional structure of the material is available at all times, an MD trajectory contains a great deal of information from which the material's properties may be deduced. Our work has involved new methodological developments in the form of a new model of the phosphate interatomic forces 9 , and MD simulations have given new insight into the structural motifs which affect the dissolution which are not accessible to experimental methods 10 . Recently, the different properties of PBG at the surface of the glass, from where the dissolution takes place have been shown, which will also be important in unravelling the full connections between structure and dissolution 11 . Molecular dynamics methods for preparation of glassesA full review of molecular dynamics methods is beyond the scope of this paper; the reader is invited to turn to relevant books 12,13 . Broadly, there are two types of molecular dynamics used to prepare realistic glass models: classical and first-principles. In classical MD, the interatomic forces are represented by an empirical expression with a small number of parameters which are chosen to reproduce existing data on the material. This method has the advantage of being relatively easy to implement and computationally inexpensive, allowing for large models (typically ∼ 10 3 − 10 4 atoms) to be simulated over long timescales (typically ns). The disadvantage is that the accuracy of the simulation is limited by the accuracy of the approximations of the interatomic potential model. First-principles MD, by contrast, uses a quantum-mechanical expression for th...

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Section: Surface Networksupporting

confidence: 89%

supporting

confidence: 89%

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

et al. 2017

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“…This vibration shifts to low frequencies when the CaO content increases, whereas the same band disappears from the spectrum when the CaO content is ≥25 mol%. The band that appears between 615 and 630 cm −1 is attributed to asymmetric vibration modes of the P-O-P skeleton [16]. All characteristic phosphate vibrations show that the bands in phosphate glasses with compositions xCaO-(40-x) ZnO-15Na 2 O-45P 2 O 5 may have chains and/or rings of metaphosphate structure with some groups of pyrophosphate structure, which is confirmed by the crystalline phases identified by X-ray diffraction.…”

Section: Infrared Spectramentioning

confidence: 57%

Chemical Durability and Structural Proprieties of the Vitreous Part of the System xCaO-(40-x)ZnO-15Na2O-45P2O5

Chabbou¹,

Aqdim²

2014

AMPC

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The influence of CaO on the glass forming characteristics and properties of Na2O-CaO-ZnO-P2O5 glasses has been investigated. According to the studies that we performed on phosphate based glass within system xCaO-(40-x)ZnO-15Na2O-45P2O5 (10 ≤ x ≤ 30; mol%), it was found that the increase of CaO and substitution of ZnO can give a good chemical durability. Both Cristallographies X-ray and IR spectroscopy have confirmed the structure change when the CaO content increases in the glass. This change results in the formation of metaphosphate and/or rings of metaphosphate groups at the expense of pyrophosphate. So it indicates the formation of Ca-O-P bonds in the network glass that replaces hydrated P-O-Na and P-O-P bands. The phosphate chains units can be bonded together in rings forming meta-phosphate groups. These rings likely lead to the formation of agglomerates of crystalline phases, which is the main cause of the increase in the chemical durability of the glasses when the CaO content increases. The latter may lead to wider use of these materials, especially in the biomedical field.

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“…Degradation studies on PBGs have frequently been conducted using deionised water and distilled water (dH2O) 4,7,[29][30][31] . In addition, In vitro media such as SBF, Simulated Urine (SU), and Phosphate Buffered Saline (PBS) have also been used as dissolution media [32][33] .…”

Section: Introductionmentioning

confidence: 99%

“…The degradation mechanisms of PBGs has been shown to vary based on changes in glass compositions 1,3,[29][30] . Phosphate-based glasses degrade in aqueous solution by reacting with H2O molecules to break the P-O-P bonds and depolymerise the network [30][31] .…”

Section: Introductionmentioning

confidence: 99%

Degradation and Characterization of Resorbable Phosphate-Based Glass Thin-Film Coatings Applied by Radio-Frequency Magnetron Sputtering

Stuart

Gimeno-Fabra

Segal

et al. 2015

ACS Appl. Mater. Interfaces

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(2015) Degradation and characterization of resorbable phosphate-based glass thin-film coatings applied by radio-frequency magnetron sputtering. ACS Applied Materials and Interfaces, 7 (49). pp. 27362-27372. ISSN 1944-8252 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/34759/1/Pre-Proof-Degradation%20and%20Characterisation %20of%20Resorbable%20Thin%20Films%20%28002%29.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: http://eprints.nottingham.ac.uk/end_user_agreement.pdf A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. respectively. This factor led to highly soluble coatings, exhibiting a t 1/2 degradation dependence in the first 2 hours in distilled water, followed by a more characteristic linear profile as the subsequent layers were less soluble. Hydration and degradation was observed to preferentially occur, forming voids characteristic of pitting corrosion which was confirmed by use of a Focused Ion Beam. Coating degradation in PBS precipitated a (PO3) -metaphosphate, X-Ray amorphous layer, which remained adherent to the substrate and seemingly formed a protective diffusion barrier which inhibited further coating degradation.The implications are that whilst compositionally similar, sputter deposited coatings and melt quenched glasses are structurally dissimilar, most notably, with regards to the surface layer.This factor has been attributed to surface etching of the as deposited coating layer during 2 deposition and variation in the thermal history between the processes of magnetron sputtering and melt quenching.

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Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5–CaO–Na2O glass system

Cited by 349 publications

References 15 publications

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Chemical Durability and Structural Proprieties of the Vitreous Part of the System xCaO-(40-x)ZnO-15Na<sub>2</sub>O-45P<sub>2</sub>O<sub>5</sub>

Degradation and Characterization of Resorbable Phosphate-Based Glass Thin-Film Coatings Applied by Radio-Frequency Magnetron Sputtering

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Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5–CaO–Na2O glass system

Cited by 349 publications

References 15 publications

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Chemical Durability and Structural Proprieties of the Vitreous Part of the System xCaO-(40-x)ZnO-15Na&lt;sub&gt;2&lt;/sub&gt;O-45P&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;5&lt;/sub&gt;

Degradation and Characterization of Resorbable Phosphate-Based Glass Thin-Film Coatings Applied by Radio-Frequency Magnetron Sputtering

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Chemical Durability and Structural Proprieties of the Vitreous Part of the System xCaO-(40-x)ZnO-15Na<sub>2</sub>O-45P<sub>2</sub>O<sub>5</sub>