2024
DOI: 10.2174/0929867330666230209094738
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Phosphate Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs

Abstract: The phosphate prodrug approach has emerged as a viable option for increasing the bioavailability of a drug candidate with low hydrophilicity and poor cell membrane permeability. When a phosphoric acid moiety is attached to the parent drug, it results in a several-fold elevation in aqueous solubility which helps to achieve desired bioavailability of the pharmaceutically active parental molecule. The neutral phosphate prodrugs have rapid diffusion ability through the plasma membrane as compared to their charged … Show more

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Cited by 6 publications
(1 citation statement)
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“…Thus, C max occurred shortly after insonation, as a guide to set time points in the net-influx phase. The present data can be references for exploring PK in other prodrug–enzyme systems. …”
mentioning
confidence: 88%
“…Thus, C max occurred shortly after insonation, as a guide to set time points in the net-influx phase. The present data can be references for exploring PK in other prodrug–enzyme systems. …”
mentioning
confidence: 88%