Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics

Kameoka, Shoichiro; Adachi, Yoshihiro; Okamoto, Koji; Iijima, Miho; Sesaki, Hiromi

doi:10.1016/j.tcb.2017.08.011

Cited by 205 publications

(207 citation statements)

References 89 publications

(99 reference statements)

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“…In these mice, although intramyocellular and membrane‐associated diacylglycerol was markedly increased, insulin resistance was not observed . PEMT, which is the key enzyme for the conversion of phosphatidylethanolamine to phosphatidylcholine, is only quantitatively significant in the liver . Mice with global PEMT knockout showed reduced fatty liver but developed glucose and insulin intolerance when fed a high fat and high choline diet .…”

Section: Experimental Evidence For the Association Between Phospholipmentioning

confidence: 97%

“…In addition, cardiolipin was shown to be required directly for activation of DRP1 . For more detailed information with regard to cardiolipin and mitochondrial dynamics see Reference . Although there is limited direct evidence connecting cardiolipin to insulin sensitivity, it is possible that cardiolipin may regulate insulin resistance through modulation of mitochondrial dynamics (Figure ).…”

Section: Experimental Evidence For the Association Between Phospholipmentioning

confidence: 99%

“…54 PEMT, which is the key enzyme for the conversion of phosphatidylethanolamine to phosphatidylcholine, is only quantitatively significant in the liver. 56 Mice with global PEMT knockout showed reduced fatty liver but developed glucose and insulin intolerance when fed a high fat and high choline diet. 57,58 In that study, choline induced glucose and insulin intolerance in PEMT global knockout mice through modulating plasma glucagon and its action in liver.…”

Section: The Association Between Phosphatidylcholine Phosphatidylementioning

confidence: 99%

See 2 more Smart Citations

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

Chang

Hatch

Wang

et al. 2018

J Cellular Molecular Medi

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Insulin resistance induced by high‐fat diet and impropriate life style is a major contributor to the pathogenesis of metabolic disease. However, the underlying molecular mechanisms remain unclear. Recent studies in metabolic dysfunction have extended this beyond simply elevated cholesterol and triglycerides levels and have identified a key role for lipid metabolism. For example, altered phospholipid metabolism has now become central in the pathogenesis of metabolic disease. In this review, we discuss the association between insulin sensitivity and phospholipid metabolism and highlight the most significant discoveries generated over the last several decades. Finally, we summarize the current knowledge surrounding the molecular mechanisms related to phospholipids and insulin resistance and provide new insight for future research into their relationship.

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Section: Experimental Evidence For the Association Between Phospholipmentioning

confidence: 97%

Section: Experimental Evidence For the Association Between Phospholipmentioning

confidence: 99%

Section: The Association Between Phosphatidylcholine Phosphatidylementioning

confidence: 99%

See 1 more Smart Citation

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

Chang

Hatch

Wang

et al. 2018

J Cellular Molecular Medi

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“…Such lipid‐mediated regulations of membrane rearrangements are only beginning to be explored. Sterols ( and references therein), phosphoinositides ( and references therein), PA and DAG ( and references therein) are among few lipids that have regulatory role in membrane fusion and fission.…”

Section: The Role Of Pa In Membrane Fusion and Membrane Fissionmentioning

confidence: 99%

Phosphatidic acid in membrane rearrangements

et al. 2019

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Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from −1 to −2 and this change stabilizes protein–lipid interactions. The biochemical properties of PA also allow interactions with lipids in several subcellular compartments. Based on this feature, PA is involved in the regulation and amplification of many cellular signalling pathways and functions, as well as in membrane rearrangements. Thereby, PA can influence membrane fusion and fission through four main mechanisms: it is a substrate for enzymes producing lipids (lysophosphatidic acid and diacylglycerol) that are involved in fission or fusion; it contributes to membrane rearrangements by generating negative membrane curvature; it interacts with proteins required for membrane fusion and fission; and it activates enzymes whose products are involved in membrane rearrangements. Here, we discuss the biophysical properties of PA in the context of the above four roles of PA in membrane fusion and fission.

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“…The phospholipid content regulates mitochondrial function, affects biogenesis and modulates protein translocation. Among the negatively charged phospholipids, including cardiolipin, phosphatidylethanolamine, and phosphatidylglycerol, cardiolipin plays a crucial role in resuming the mitochondrial membrane architecture and recruiting soluble components to the membrane to maintain mitochondrial dynamics [64,65]. Cardiolipin also interacts with several mitochondrial fusion-and division-associated molecules, including OPA1, Mfn, and Drp1, to regulate the function of these dynamin-related GTPases.…”

Section: Viral Targeting Of Specific Mitochondrial Moleculesmentioning

confidence: 99%

Operation of mitochondrial machinery in viral infection-induced immune responses

Lai

Luo

2018

Biochemical Pharmacology

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Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infections. In this commentary, we address several interesting questions, including (1) how do mitochondrial machineries participate in immune responses; (2) how do mitochondria mediate antiviral immunity; (3) what mechanisms involved in mitochondrial machinery, including the downregulation of mitochondrial DNA (mtDNA), disturbances of mitochondrial dynamics, and the induction of mitophagy and regulation of apoptosis, have been adopted by viruses to evade antiviral immunity; (4) what mechanisms involve the regulation of mitochondrial machineries in antiviral therapeutics; and (5) what are the potential challenges and perspectives in developing mitochondria-targeting antiviral treatments? This commentary provides a comprehensive review of the roles and mechanisms of mitochondrial machineries in immunity, viral infections and related antiviral therapeutics.

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Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics

Cited by 205 publications

References 89 publications

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

Phosphatidic acid in membrane rearrangements

Operation of mitochondrial machinery in viral infection-induced immune responses

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