Phosphatidylcholine attenuated docetaxel-induced peripheral neurotoxicity in rats

Kim, Sung Tae; Kyung, Eun; Suh, Jung Sook; Lee, Ho Sung; Lee, Jun Ho; Chae, Soo In; Park, Eon Sub; Chung, Yoon Hee; Bae, Jinhyung; Lee, Tae Jin; Lee, Won Mo; Sohn, Uy Dong; Jeong, Ji Hoon

doi:10.1080/01480545.2017.1390580

Cited by 22 publications

(12 citation statements)

References 36 publications

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“…After 12 weeks of whole-body vibration, the main metabolites involved in changes in the glycerol phospholipid metabolism pathway were phosphatidylcholine and phosphatidylethanolamine in the skeletal muscle of ageing mice. The abnormal metabolism of phosphatidylcholine is closely related to the abnormal regulation of blood glucose [28], atherosclerosis [29], and stroke [30], mostly because phosphatidylcholine can prevent injury induced by antioxidant enzymes and reduce the inflammatory response of cells [31]. Lysophosphatidylcholine is a degradation product of phos- phatidylcholine.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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Ageing increases the occurrence and development of many diseases. Exercise is believed to be an effective way to improve ageing and skeletal muscle atrophy. However, many elderly people are unable to engage in active exercise. Whole-body vibration is a passive way of moving that is especially suitable for the elderly and people who find it inconvenient to exercise. Metabolomics is the systematic study of metabolic changes in small molecules. In this study, metabolomics studies were performed to investigate the regulatory effect of whole-body vibration on the skeletal muscles of ageing mice. After 12 weeks, we found that whole-body vibration had the most obvious effect on lipid metabolism pathways (such as linoleic acid, α-linolenic acid metabolism, glycerophospholipid metabolism pathways) in skeletal muscle of ageing mice. Through further research we found that whole-body vibration decreased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein in blood; decreased the lipid deposition in skeletal muscle; decreased the protein expression of monocyte chemoattractant protein-1 and interleukin-6; improved the protein levels of phosphorylated insulin receptor substrate-1, phosphate phosphoinositide 3-kinase and p-AKT; improved the protein levels of klotho; and decreased the protein expression of p53. These findings reveal that whole-body vibration might postpone senility by attenuating lipid deposition and reducing chronic inflammation and the insulin resistance of skeletal muscle.

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Section: Discussionmentioning

confidence: 99%

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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“…Its antioxidant activity has been demonstrated in different animal models, including in neuropathic pain models induced by cisplatin or docetaxel. Phosphatidylcholine antinociceptive actions were due to its ability to increase the antioxidant defence, thus decreasing neuronal damage in the sciatic nerve and modulating microglia activity in the spinal cord (Kim et al, 2018).…”

Section: Mitochondrial Dysfunction and Oxidative Stressmentioning

confidence: 99%

Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives

Costa

Passos

Quintão

et al. 2020

British J Pharmacology

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Taxane-derived drugs are antineoplastic agents used for the treatment of highly common malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however, other drugs and formulations have been used, such as cabazitaxel and nabpaclitaxel. Taxane treatment is associated with neurotoxicity, a well-known and relevant side effect, very prevalent amongst patients undergoing chemotherapy. Painful peripheral neuropathy is the most dose-limiting side effect of taxanes, affecting up to 97% of paclitaxel-treated patients. Central neurotoxicity is an emerging side effect of taxanes and it is characterized by cognitive impairment and encephalopathy. Besides impairing compliance to chemotherapy treatment, taxane-induced neurotoxicity (TIN) can adversely affect the patient's life quality on a long-term basis. Despite the clinical relevance, not many reviews have comprehensively addressed taxaneinduced neurotoxicity when they are used therapeutically. This article provides an up-to-date review on the pathophysiology of TIN and the novel potential therapies to prevent or treat this side effect. Abbreviations: Ca v , voltage-gated calcium; CB 1 , cannabinoid receptor 1; CB 2 , cannabinoid receptor 2; CCL2, chemokine (C-C motif) ligand 2; CCR2, CC motif chemokine receptor 2; CIPN, chemotherapy-induced peripheral neuropathy; CREB, cAMP response element-binding; CX3CL1, C-X3-C motif chemokine ligand 1; CXCL1, C-X3-C motif chemokine ligand 1; CXCL12, C-X-C motif chemokine ligand 12; CXCR1, C-X-C motif chemokine receptor 1; CXCR2, C-X-C motif chemokine receptor 2; DRG, dorsal root ganglion; GHS-R, growth hormone secretagogue receptor; IENFs, intra-epidermal nerve fibres; K ATP , ATP-sensitive potassium channel; K v , voltage-gated potassium channel; mPTP, mitochondrial permeability transition pore; Na v , voltage-gated sodium channel; Nrf2, nuclear factor-2 erythroid-related factor-2; PIPN, paclitaxel-induced peripheral neuropathy; TICN, taxane-induced central neurotoxicity; TIN, taxane-induced neurotoxicity; TIPN, taxane-induced peripheral neuropathy; TLR4, toll-like receptor-4; TRPA1, transient receptor potential cation channel subfamily A member 1; TRPV1, transient receptor potential cation channel subfamily V member 1; TRPV4, transient receptor potential cation channel subfamily V member 4.

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“…Dyshomeostasis of lipids or fatty acids in neurons has been found to mediate CNS disorders. For instance, the disruption of PC homeostasis mediates a series of neuropathies (Kim et al 2018; Yu-Yuan and Yi-Jun, 2020), and accumulation of arachidonic acid-containing PC species in the hypothalamus and striatum mediates the depressive behavior in rats (Green et al 2009). Therefore, we propose that the dysregulated lipids may contribute to abnormal neurobehaviors caused by cefepime in mice.…”

Section: Discussionmentioning

confidence: 90%

Lipidomics Reveals Glycerophospholipid Metabolism Dysregulation in the Corpus Striatum of Mice Treated with Cefepime

Liu

Wang

Wei

et al. 2021

Preprint

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Cefepime exhibits a broad spectrum of antimicrobial activity and thus is widely used for severe bacterial infection. Adverse effects on the central nervous system (CNS) have been reported in the patients treated with cefepime. Current explanation for the neurobehavioral effect of cefepime mainly attributes to its ability to across blood-brain barrier and to competitively bind to GABAergic receptor; however, the underlying mechanism is largely unknown. In this study, mice were intraperitoneally administered 80 mg/kg cefepime for different time period, including 1 day, 3 days, 5 days, 7 days and 10 days, and then LC/MS-MS-based metabolomics was used to investigate the effect of cefepime on the brain lipidomic profiling and metabolic pathway. Repeated cefepime treatment time-dependently caused anxiety-like behavior accompanied with the reduced locomotor activity in the open field test. Cefepime profoundly altered the lipid profile in the corpus striatum, and glycerophospholipid contributed to a large proportion among those significantly modified lipids. Cefepime also significantly modified acyl chain length and unsaturation of fatty acids. In addition, cefepime obviously altered the morphology of neurite, mitochondria and synaptic vesicles of striatal neuron in vitro. Collectively, our results show that cefepime reprograms glycerophospholipid metabolism of corpus striatum, which may underly its neurobehavioral effect.

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Phosphatidylcholine attenuated docetaxel-induced peripheral neurotoxicity in rats

Cited by 22 publications

References 36 publications

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives

Lipidomics Reveals Glycerophospholipid Metabolism Dysregulation in the Corpus Striatum of Mice Treated with Cefepime

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