Phosphatidylethanols in Breath: A Possible Noninvasive Screening Test for Heavy Alcohol Consumption

Helander, Anders; Ullah, Shahid; Beck, Olof

doi:10.1373/clinchem.2015.239848

Cited by 11 publications

(2 citation statements)

References 5 publications

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“…Blood PEth levels were found to correlate with reported ethanol intake of alcoholic subjects and threshold levels considered typical of chronic ethanol abuse have been proposed to discriminate between moderate drinking and chronic ethanol abuse . Other matrices suitable for the detection of PEth are exhaled breath and umbilical cord .…”

Section: Phosphatidylethanolmentioning

confidence: 99%

Nonoxidative ethanol metabolism in humans—from biomarkers to bioactive lipids

2016

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Ethanol is a widely used psychoactive drug whose chronic abuse is associated with organ dysfunction and disease. Although the prevalent metabolic fate of ethanol in the human body is oxidation a smaller fraction undergoes nonoxidative metabolism yielding ethyl glucuronide, ethyl sulfate, phosphatidylethanol and fatty acid ethyl esters. Nonoxidative ethanol metabolites persist in tissues and body fluids for much longer than ethanol itself and represent biomarkers for the assessment of ethanol intake in clinical and forensic settings. Of note, the nonoxidative reaction of ethanol with phospholipids and fatty acids yields bioactive compounds that affect cellular signaling pathways and organelle function and may contribute to ethanol toxicity. Thus, despite low quantitative contributions of nonoxidative pathways to overall ethanol metabolism the resultant ethanol metabolites have important biological implications. In this review we summarize the current knowledge about the enzymatic formation of nonoxidative ethanol metabolites in humans and discuss the implications of nonoxidative ethanol metabolites as biomarkers of ethanol intake and mediators of ethanol toxicity. © 2016 IUBMB Life, 68(12):916–923, 2016

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Section: Phosphatidylethanolmentioning

confidence: 99%

Nonoxidative ethanol metabolism in humans—from biomarkers to bioactive lipids

2016

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“…The collection is reported to be convenient, rapid, safe and well accepted by volunteers. Two feasibility studies have also demonstrated that phosphatidylethanols for testing alcohol consumption, along with phosphatidylcholines for surfactant analysis, could be analyzed in exhaled breath collected with the SB [29,30]. From a chemical point of view, 8-isoprostane might be related to these hydrophobic lipid compounds.…”

Section: Introductionmentioning

confidence: 99%