Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation

Filgueiras, Cláudio C.; Krahe, Thomas E.; Medina, Alexandre E.

doi:10.1016/j.neulet.2010.02.046

Cited by 47 publications

(44 citation statements)

References 38 publications

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“…could improve learning and memory in animal models of fetal alcohol spectrum disorders (FASD) on Long Evans rats. 14) Also, Chronic treatment with vinpocetine (5, 10, 20 mg/kg i.p.) for 21 d following first i.c.v.…”

Section: Discussionmentioning

confidence: 99%

Vinpocetine Improves Scopolamine Induced Learning and Memory Dysfunction in C57 BL/6J Mice

Yu¹,

Wang²,

et al. 2016

Biological & Pharmaceutical Bulletin

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Vinpocetine is an inhibitor of phosphodiesterase type 1 (PDE1), which has been used for treating stroke for over 40 years. However, according to current clinical dosage and treatment period, its direct effect on memory is unclear. In this study, we investigated whether vinpocetine could reverse the scopolamine (SCO)-induced cognitive deficits in animals. Behavioral experiments, including open field, Y-maze, and fear conditioning tests were used to determine the possible role of vinpocetine on scopolamine-induced memory dysfunction. In the open field and Y-maze tests, there were significant differences between the control (CON) group and SCO group. Vinpocetine (4 mg/kg) administration for consecutive 28 d significantly improved the scopolamine-induced memory dysfunction. In the fear conditioning test, vinpocetine (2, 4 mg/kg) administration had certain beneficial effect on emotional memory. Our results suggest that vinpocetine could improve cognitive function in memory deficient mice and high clinic dosage might be better. Key words vinpocetine; scopolamine; memory dysfunction; behavior testDiscovered in the late 1960 s, 1) it is currently popular in China and Hungary for treating cerebral ischemia. Its structure is shown in Fig. 1.2) Although used in the treatment of cerebral ischemia for over 40 years, vinpocetine is widely marketed only as a dietary supplement for vasodilation and as a nootropic for the improvement of memory 3); it has not been approved by any regulatory body for the treatment of cognitive impairment.2,4,5) Many basic science studies have shown that vinpocetine has a variety of potentially important effects on the brain. Despite these proposed mechanisms and targets, the relevance of these basic science findings in clinical studies is unclear. As an inhibitor of phosphodiesterase type 1 (PDE1), it increases cAMP and cGMP levels to increase blood circulation and metabolism in the brain. 6,7)Vinpocetine might enhance memory deficit through the modulation of cholinergic functions. 8) Traditionally, scopolamine (SCO) has been used in the field of neuropsychopharmacology as a standard/reference drug for dementia-related cognitive deficits model. 9) Deshmukh et al. found chronic treatment with vinpocetine (5, 10 and 20 mg/kg intraperitoneally (i.p.)) for 21 d following first intracerebro-ventriculas (i.c.v.) streptozotocin infusion significantly improved learning and memory in Morris water maze and passive avoidance paradigms.10) DeNoble et al. found that vinpocetine (3 mg/kg per os (p.o.)) was also effective in preventing disruption of passive avoidance retention impaired by 7% oxygen-induced hypoxia.8) These data support the view that vinpocetine can improve cognitive ability on scopolamine and hypoxia-induced memory impairment rats, but whether it could improve memory effects by clinical dosage and treatment period is still unclear.In the present study, we used behavioral analyses to test the possible role of vinpocetine on scopolamine-induced dementia in C57BL/6J mice by clinical dosage and trea...

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Section: Discussionmentioning

confidence: 99%

Vinpocetine Improves Scopolamine Induced Learning and Memory Dysfunction in C57 BL/6J Mice

Yu¹,

Wang²,

et al. 2016

Biological & Pharmaceutical Bulletin

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“…PDE inhibitor can improve neural plasticity or restore this function in different neurological conditions [71,72]. Vinpocetine treatment was also shown to revert the effects of early alcohol exposure in learning performance in the water maze [73]. It was recently demonstrated that vinpocetine has a strong anti-inflammatory effect [74].…”

Section: Inhibitors With Therapeutic Actionmentioning

confidence: 99%

Pharmacological Potential of PDE5 Inhibitors for the Treatment of Cystic Fibrosis

Lubamba¹,

Dhooghe²,

Noël³

et al. 2012

Cystic Fibrosis - Renewed Hopes Through Research

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“…Vinpocetine treatment has been shown to facilitate long-term potentiation (9), improve spatial memory in animal models (6,7), and enhance performance on cognitive tests in humans (10). The cognitive enhancement function of vinpocetine comes from its inhibition of PDE type 1, which leads to an increase in cAMP and cGMP levels.…”

Section: Vinpocetine Improves Neuronal Plasticitymentioning

confidence: 99%

“…Currently, there are great efforts to discover antiinflammatory drugs that can be used for long periods with minimal side effects. In PNAS, Jeon et al (2) show that vinpocetine, a phosphodiesterase (PDE) inhibitor known for its minimal side effects (3,4) and great potential in cognitive enhancement (5)(6)(7)(8), also has potent antiinflammatory action. Surprisingly, the antiinflammatory action of vinpocetine is caused by a direct inhibition of the IκB kinase complex (IKK) rather than PDE blockade.…”

mentioning

confidence: 99%

Vinpocetine as a potent antiinflammatory agent

Medina

2010

Proc. Natl. Acad. Sci. U.S.A.

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Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation

Cited by 47 publications

References 38 publications

Vinpocetine Improves Scopolamine Induced Learning and Memory Dysfunction in C57 BL/6J Mice

Vinpocetine Improves Scopolamine Induced Learning and Memory Dysfunction in C57 BL/6J Mice

Pharmacological Potential of PDE5 Inhibitors for the Treatment of Cystic Fibrosis

Vinpocetine as a potent antiinflammatory agent

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