Phosphoglyceride crystal deposition disease mimicking a malignant tumor

Tokue, Hiroyuki; Ebara, Masayuki; Takahashi, Ryuji; Tokue, Azusa; Tsushima, Yoshito

doi:10.1016/j.ejro.2018.01.004

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…These PG crystals are characterized by numerous refractions under polarized light and positive staining with GHA 1 . PGDD results in the formation of single or multiple masses in the soft tissue or extra-articular bones, and these masses are often radiologically misdiagnosed as malignant tumors 9 . The present case is the first reported case of PGDD treated with curettage of the whole lesion and artificial bone grafting.…”

Section: Discussionmentioning

confidence: 99%

Phosphoglyceride Crystal Deposition Disease of the Scapula

Hori¹,

Nagano²,

Miyazaki

et al. 2023

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Case:A 76-year-old woman presented with a 2-month history of right shoulder pain with no apparent cause. Radiography revealed an ill-defined osteolytic lesion in the right scapular spine with a pathological fracture. Malignant bone tumor was suspected, and a biopsy was performed. Pathological examination with gold hydroxamic acid staining revealed phosphoglyceride crystal deposition. Lesion curettage was performed, and her symptoms improved. No recurrence was observed at the 3-year postoperative follow-up.Conclusion:Phosphoglyceride crystal deposition in the bone is an extremely rare disease. The gold hydroxamic acid staining method might be useful for the diagnosis of this condition.

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Section: Discussionmentioning

confidence: 99%

Phosphoglyceride Crystal Deposition Disease of the Scapula

Hori¹,

Nagano²,

Miyazaki

et al. 2023

JBJS Case Connector

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“…The FDG uptake in two previous reported cases of PCDD ranged from 13.6 to 26.0[ 3 , 4 ]. Our patient had even higher uptake, ranging from 34 to 37, in all of her many masses.…”

Section: Discussionmentioning

confidence: 99%

“…In previous reports, phosphoglyceride has been identified by the gold hydroxamic acid method, X-ray microanalysis, and microstamping mass spectrometry[ 1 ]. Clinically, on 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET), phosphoglyceride deposits have been reported to show a maximum standardized uptake value (SUVmax) ranging from 13.6 to 26.0[ 3 , 4 ]. Here, we report a case of PCDD showing extremely high uptake on 18 F-FDG-PET in which Raman spectroscopy led to a definitive diagnosis of PCCD.…”

Section: Introductionmentioning

confidence: 99%

Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report

Ohkura¹,

Uruga²,

Shiiba³

et al. 2022

WJCC

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BACKGROUND Phosphoglyceride crystal deposition disease (PCDD) is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery, trauma, or repeated injections. CASE SUMMARY A 60-year-old-woman was referred to our department because of multiple abdominal masses after open splenectomy for idiopathic thrombocytopenic purpura 29 years earlier. All the masses showed marked fluorodeoxyglucose (FDG) uptake on 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET) and were strongly suspected to be malignant tumors. Surgical biopsies were performed, and the abdominal masses were found to be aligned vertically, three in a row, along the tissue layers cut in the patient’s previous surgery. Pathological finding of the specimens showed foreign body granuloma consisting of histiocytes and multinucleated giant cells accumulating around needle-like crystals. The crystals were confirmed as phosphoglyceride by Raman spectroscopy, and PCDD was diagnosed. To our knowledge, this is the first report of PCDD diagnosed by Raman spectroscopy. CONCLUSION We made a definitive diagnosis of PCDD in a patient with multiple tumors showing marked FDG uptake on 18 F-FDG-PET by incisional biopsy and compo- sition analysis using Raman spectroscopy, a method that has not previously been reported for the diagnosis of PCDD.

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“…PCDD is extremely rare; to the best of our knowledge, only 12 cases, all from Japan, have been reported to date 1-10 . In 10 of these cases, the lesions developed at the site of postoperative scar or repeated injections on the body surface (abdominal wall 1 , 3 , 9 , buttock 2 and upper arm 3 ) as well as in internal organs (peritoneum 4 , spine 5 , anterior mediastinum 6 , 8 , cardiac wall 10 , and pelvic wall 7 ) a long time (20-45 years) after operation/injection. These findings suggest that tissue injury may play an important role in PG deposition, while its developmental process is still largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Phosphoglyceride crystal deposition disease involving adnexa uteri: a case report with histogenetic consideration

Nakamura¹,

Fujiwara²,

Hara³

et al. 2021

Pathologica

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Summary We present a rare case of phosphoglyceride crystal deposition disease (PCDD), as a gynecologic disease, with reference to histogenesis of crystal deposition. An 84-year-old woman, who had undergone simple hysterectomy for uterine leiomyoma 44 years previously, presented with multiple masses in the bilateral adnexa and the pelvic wall. The bilateral adnexal tumors were resected. The masses histologically revealed a foreign-body granuloma composed of numerous tiny, radially arranged needle-like crystal lumps surrounded by multinucleated giant cells and macrophages. The crystals showed birefringence under polarized light and were positive for gold hydroxamic acid stain, and the tumor was thus diagnosed as PCDD. The masses revealed central cystic changes due to old hemorrhage, which contained crystal lumps without foreign-body reaction or birefringence. The present case demonstrated for the first time that phosphoglyceride crystals developed in old hemorrhagic foci, although it was not confirmed whether the old hemorrhagic foci were formed after hysterectomy or due to endometriosis.

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Phosphoglyceride crystal deposition disease mimicking a malignant tumor

Cited by 8 publications

References 8 publications

Phosphoglyceride Crystal Deposition Disease of the Scapula

Phosphoglyceride Crystal Deposition Disease of the Scapula

Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report

Phosphoglyceride crystal deposition disease involving adnexa uteri: a case report with histogenetic consideration

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