Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1

Lee, Hyesung; Jung, Taek-Yeol; Lim, Seong Hun; Choi, Eun Ju; Lee, Jinu; Min, Do Sik

doi:10.1038/s12276-021-00659-y

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…Current studies have highlighted the crucial role of SIRT1 as an upstream target of p53. For instance, SIRT1 overexpression inhibits p53 acetylation in response to p53-dependent apoptosis. − SIRT1 can suppress p53 acetylation and reverse its combination with the DPR1 promoter, reduce mPTP opening, increase the ATP content, and inhibit caspase 3 activation, thereby inhibiting mitochondrial fission and ultimately attenuating apoptosis. ,, In our results, allicin decreased the level of p53 acetylation, and laser confocal observation further confirmed that the interaction degree of SIRT1 with ace-p53 was dose-dependently restored by allicin, indicating that SIRT1 attenuated mitochondrial apoptosis by crosstalk with p53.…”

Section: Discussionsupporting

confidence: 71%

Allicin Alleviates Mitochondrial Dysfunction in Acrylamide-Induced Rat Kidney Involving the Regulation of SIRT1

Li,

Wang,

et al. 2023

J. Agric. Food Chem.

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Acrylamide (AA), commonly formed in carbohydrate-rich thermally processed foods, exerts harmful effects on the kidney. Allicin, from crushed garlic cloves, exhibits strong biological activities. In the current study, the protection mechanisms of allicin against AA-caused nephrotoxicity were comprehensively examined using an in vivo rat model based on previous research that allicin plays a key role in improving renal function. The results showed that allicin attenuated histological changes of the kidney and ameliorated renal function. Damaged mitochondrial structures, upregulated voltage-dependent anion channel 1 expression, and decreased membrane potential and adenosine 5′-triphosphate levels were observed after AA treatment. Surprisingly, allicin notably reversed the adverse effects. Further, allicin effectively restored mitochondrial function via modulating mitochondrial biogenesis and dynamics, which might be associated with the upregulated expression of sirtuin 1 (SIRT1). Meanwhile, allicin dramatically activated the SIRT1 activity and subsequently inhibited p53 acetylation, prevented the translocation of cytochrome c to the cytoplasm, and reduced the caspase expression, thus further inhibiting mitochondrial apoptosis caused by AA. In summary, the relieving effect of allicin on AA-caused nephrotoxicity lies in its inhibition of mitochondrial dysfunction and mitochondrial apoptosis.

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Section: Discussionsupporting

confidence: 71%

Allicin Alleviates Mitochondrial Dysfunction in Acrylamide-Induced Rat Kidney Involving the Regulation of SIRT1

Li,

Wang,

et al. 2023

J. Agric. Food Chem.

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“…The anti-aging gene sirtuin 1 (SIRT1) has been reported to be associated with LUAD and non-small cell lung cancer and high protein level of SIRT1 has been shown to indicate poor prognosis of lung cancer patients [18,[31][32][33]. SIRT1 is involved with transcription dysregulation including deacetylation of transcription factors such as p53 and DNA methylation [34][35][36]. Prior researchers showed that HOXA5 and p53 co-worked to retard lung cancer cell invasion and served as good prognostic factors in non-small cell lung cancer [12].…”

Section: Discussionmentioning

confidence: 99%

Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma

Li¹,

He²,

Huang³

et al. 2022

Int. J. Med. Sci.

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Background: The role of HOXA family genes in the occurrence and progression of a variety of human cancers has been scatteredly reported. However, there is no systematic study on the differential expression, prognostic significance and potential molecular mechanism of HOXA4 and HOXA5 in LUAD. Methods: In-house immunohistochemistry (IHC), multi-center microarrays, RT-qPCR and RNA-seq data were incorporated for comprehensively evaluating the expression and prognostic value of HOXA4 and HOXA5 in LUAD. The mechanism of HOXA4 and HOXA5 in the formation and development of LUAD was analyzed from multiple aspects of immune correlations, upstream transcriptional regulation, functional states of single cells and co-expressed gene network. The functional roles of HOXA4 and HOXA5 in LUAD were validated by in vitro experiments. Results: As a result, in 3201 LUAD samples and 2494 non-cancer lung samples, HOXA4 and HOXA5 were significantly downexpressed (P < 0.05). The aberrant expression of HOXA5 was significantly correlated with the clinical progression of LUAD (P < 0.05). HOXA5 showed remarkable prognostic value for LUAD patients (P < 0.05). The expression of HOXA4 and HOXA5 in LUAD were negatively correlated with tumor purity and positively correlated with the infiltration of various immune cells such as B cells, T cells and macrophages. HOXA4 and HOXA5 overexpression had notable inhibitory effect on the proliferation, migration and invasion of LUAD cells. Conclusions: In conclusion, the identified downexpressed HOXA4 and HOXA5 had significant distinguishing ability for LUAD samples and affected the cellular functions of LUAD cells. The low expression of HOXA5 indicated worse overall survival of LUAD patients. Therefore, the two HOXA family genes especially HOXA5 may serve as potential biomarkers for LUAD.

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“…The up-regulation of MALAT1 promotes the deacetylation of p53 at K382, thereby inhibiting the transactivation of p53-inducible genes, including p21, BAX, and PUMA. Phospholipase D2 (PLD2) positively modulates SIRT1 and suppresses p53-dependent apoptosis [ 163 ]. L173 and L174 in the LXXLL motif of PLD2 interact with the C-terminal region of SIRT1, thereby stimulating the deacetylase activity of SIRT1.…”

Section: Regulators Of P53 Deacetylasementioning

confidence: 99%

Insights into Regulators of p53 Acetylation

Nagasaka

Miyajima

Aoki

et al. 2022

Cells

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The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the selectivity of target genes. Acetylation plays an essential role in cell fate determination through the activation of p53. Although the acetylation of p53 has been examined, the underlying regulatory mechanisms remain unclear and, thus, have attracted the interest of researchers. We herein discuss the role of acetylation in the p53 pathway, with a focus on p53 acetyltransferases and deacetylases. We also review recent findings on the regulators of these enzymes to understand the mode of p53 acetylation from a broader perspective.

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Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1

Cited by 9 publications

References 48 publications

Allicin Alleviates Mitochondrial Dysfunction in Acrylamide-Induced Rat Kidney Involving the Regulation of SIRT1

Allicin Alleviates Mitochondrial Dysfunction in Acrylamide-Induced Rat Kidney Involving the Regulation of SIRT1

Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma

Insights into Regulators of p53 Acetylation

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