1996
DOI: 10.4267/10608/735
|View full text |Cite
|
Sign up to set email alerts
|

Phospholipases A2 et pathologie inflammatoire : consensus et nouveaux concepts

Abstract: l'origine, les phospholipases A 2 (PLA 2) ont été identifiées comme des enzymes particulièrement abondantes dans les venins de serpents et le suc pancréatique où elles jouent un rôle digestif évident, doublé d'un rôle toxique dans le premier cas. Mais l'intérêt biologique de ces enzymes repose aussi sur leur implication directe dans la régulation de la biosynthèse de médiateurs lipidiques, tels que les multiples dérivés de l'acide arachido-nique et le facteur activant les plaquettes ou PAF-acéther (figure 1, v… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0
1

Year Published

1997
1997
2019
2019

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(6 citation statements)
references
References 8 publications
0
5
0
1
Order By: Relevance
“…In a more recent study, we have focused our attention on the possible involvement of secretory non‐pancreatic PLA 2 (snpPLA 2 or type II PLA 2 ) in the generation of lipid mediators like LPA [34]. This enzyme is produced by a number of cells stimulated by pro‐inflammatory cytokines such as interleukin‐1β or tumor necrosis factor‐α and it accumulates in inflammatory fluids as well as in the plasma of patients suffering from septic shock [35–37]. In these situations, the amounts of snpPLA 2 secreted in these extracellular media reflect the severity of the inflammatory reaction [35–37].…”
Section: Loss Of Membrane Phospholipid Asymmetry Regulating Phosphatimentioning
confidence: 99%
See 1 more Smart Citation
“…In a more recent study, we have focused our attention on the possible involvement of secretory non‐pancreatic PLA 2 (snpPLA 2 or type II PLA 2 ) in the generation of lipid mediators like LPA [34]. This enzyme is produced by a number of cells stimulated by pro‐inflammatory cytokines such as interleukin‐1β or tumor necrosis factor‐α and it accumulates in inflammatory fluids as well as in the plasma of patients suffering from septic shock [35–37]. In these situations, the amounts of snpPLA 2 secreted in these extracellular media reflect the severity of the inflammatory reaction [35–37].…”
Section: Loss Of Membrane Phospholipid Asymmetry Regulating Phosphatimentioning
confidence: 99%
“…This enzyme is produced by a number of cells stimulated by pro‐inflammatory cytokines such as interleukin‐1β or tumor necrosis factor‐α and it accumulates in inflammatory fluids as well as in the plasma of patients suffering from septic shock [35–37]. In these situations, the amounts of snpPLA 2 secreted in these extracellular media reflect the severity of the inflammatory reaction [35–37]. A classical view is to consider that snpPLA 2 might be involved as a distal effector of inflammation participating in the release of arachidonic acid or lysophospholipids, thus allowing the synthesis of various lipid mediators [36].…”
Section: Loss Of Membrane Phospholipid Asymmetry Regulating Phosphatimentioning
confidence: 99%
“…This translocation was stimulated by an increase in cytosolic calcium concentration and involved a phosphorylation of the enzyme. 21,22 When cells were stimulated, the increase in calcium concentration to a micromolar level induced the interaction of phospholipase A 2 with membrane phospholipids, whereas phosphorylation of phospholipase A 2 induced an increase in its activity. Therefore membrane-associated phospholipases would be the physiologically active form, while the cytosolic phospholipases would constitute a reservoir of potential activity.…”
Section: 917±19mentioning
confidence: 99%
“…En ce qui concerne les messagers lipidiques, le premier requis est, généralement, le premier à être vérifié. Mais les requis (2) [13][14][15]). Les sPLA2 sont des enzymes de petit poids moléculaire (13-18 kDa), extracellulaires, retrouvées dans les venins de serpent, le pancréas de mammifère, le liquide synovial.…”
Section: Les Seconds Messagers De La Signalisation Hormonaleunclassified