Phospholipid bilayer responses to ultrasound-induced microbubble cavitation phenomena

Walsh, Martin P.; Tikekar, Rohan V.; Nitin, Nitin; Wrenn, Steven P.

doi:10.1016/j.jfoodeng.2020.110410

Cited by 5 publications

(5 citation statements)

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“…The intense physical and chemical conditions that come from this have the ability to disturb the cytoskeleton, cell membrane structure, and biological enzyme function, ultimately leading to the death of the cell. [88][89][90][91] Cavitation, a phenomenon induced by acoustic forces, gives rise to intricate cellular responses, such as sonoluminescence (SL) and sonoporation in biomedical engineering. Sonoluminescence, a process characterized by light emission during cavitation, orchestrates the excitation of electron orbitals in sonosensitizers through energy-transfer mechanisms.…”

Section: Deciphering the Intricacies Of Sonodynamic Therapy Mechanism...mentioning

confidence: 99%

Recent breakthroughs in graphene quantum dot-enhanced sonodynamic and photodynamic therapy

Mousavi,

Kalashgrani,

Javanmardi

et al. 2024

J. Mater. Chem. B

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Section: Deciphering the Intricacies Of Sonodynamic Therapy Mechanism...mentioning

confidence: 99%

Recent breakthroughs in graphene quantum dot-enhanced sonodynamic and photodynamic therapy

Mousavi,

Kalashgrani,

Javanmardi

et al. 2024

J. Mater. Chem. B

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“…[37] US-induced cavitation effects are an important mechanism of SDT. [38,39] The mechanism of the cavitation effect is very complex including inertial cavitation and non-inertial cavitation; these are closely related to the gas oscillation. [27,40] Gas bubbles release energy when they break up rapidly due to exposure to US.…”

Section: •−mentioning

confidence: 99%

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Yang

et al. 2021

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Some acoustically active substances can combine with specific molecules/cells and enable imaging of complex disease processes at the molecular level. [8,9] In parallel, accumulating evidence demonstrates that US is an appealing regimen for managing various diseases including Alzheimer's diseases, cardiovascular diseases, and cancers. [10][11][12][13] According to the frequency, US is usually categorized into high intensity focused US (HIFU; >200 kHz) and low intensity focused US (LIFU; 20-200 kHz). [14] HIFU enables truly non-invasive tumor ablation in clinical applications. [15] There have been tens of thousands of cases reporting HIFU guided by US or magnetic resonance imaging to treat solid organ tumors globally. [16,17] However, recent investigations indicate that the administration of HIFU can lead to adverse events such as skin burn and nerve injury. [18] Theoretically, LIFU with lower intensity can eliminate US-induced overheating and make the treatment safer. LIFU radiation combined with sonosensitizer administration (sonodynamic therapy, SDT), was developed as a suitable therapy alternative by Yumita et al. in 1989. [19] When US activates the preloaded sonosensitizers, they can trigger sensitive reactions to produce reactive oxygen species (ROS), which play a therapeutic role in specific sites through different mechanisms. [20,21] More importantly, due to the excellent regional focusing characteristics and strong tissue penetrating ability of US, SDT has higher therapeutic efficiency and fewer side effects. [22,23] Recent intriguing investigations had been carried out using SDT to treat cancer, cardiovascular disease, and multidrug-resistant (MDR) bacterial infection. [24] Notably, SDT of cancer and atherosclerotic peripheral artery disease (PAD) has been applied in clinical trials, and the results showed high efficacy and favorable safety on patients. [25,26] The sonosensitization efficiency, ROS quantum yield, and accumulation of the sonosensitizers in the target cells are essential prerequisites for SDT. [27,28] Therefore, designing and developing excellent sonosensitizers is an important topic in the development of SDT. Generally, sonosensitizers mainly include organic and inorganic sonosensitizers. Many inorganic sonosensitizers have superior physiochemical properties, but the clinical translation remains unresolved because of nonbiodegradation and potential biosafety issues. However, organic sonosensitizers have the advantages of clear structure and easy metabolism, which is conducive to clinical applications. [24] Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low-intensity ultrasound and sonosensitizers. Versus photomediated therapy, SDT has the advantages of deeper tissue penetration, high accuracy, and less side effects. Sonosensitizers are critical for therapeutic efficacy during SDT and organic sonosensitizers are important because of their clear structure, easy monitoring, evaluation of drug metabolism, and clinical transformation. Notably, nanotechnolo...

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“…The extreme physical conditions and chemical groups generated by collapse can pose destructive effects on the cytoskeleton, cell membrane structure, and biological enzyme activity and can even kill surrounding cells. [29][30][31][32] In addition, cavitation leads to sonoluminescence (SL) and sonoporation. Through energy transfer, sonoluminescence excites the electron orbitals of the sonosensitizer, and they can produce electron holes (e À -h + ), which can pair with the subsequently generated ROS.…”

Section: Ultrasound Cavitation Effect Theorymentioning

confidence: 99%

Section: The Mechanism Of Sdtmentioning

confidence: 99%

Application of nanosonosensitizer materials in cancer sono-dynamic therapy

Hou

Xie

2022

RSC Adv.

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Phospholipid bilayer responses to ultrasound-induced microbubble cavitation phenomena

Cited by 5 publications

References 28 publications

Recent breakthroughs in graphene quantum dot-enhanced sonodynamic and photodynamic therapy

Recent breakthroughs in graphene quantum dot-enhanced sonodynamic and photodynamic therapy

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Application of nanosonosensitizer materials in cancer sono-dynamic therapy

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