Phospholipid Composition of Erythrocytes and Glutathione Redox System in Rats during Adaptation to Cholesterol Load

Abstract

We studied phospholipid composition of erythrocytes and the state of the glutathione redox system in rats during adaptation to cholesterol load for 180 days. The adaptive response is formed during the period from day 30 to day 90 of cholesterol load and is associated with increased relative content of phosphatidylethanolamine and phosphatidylinositol, activation of glutathione redox system enzymes (glutathione reductase and glutathione peroxidase), and enhanced production of glutathione.

Effects on Alimentary High-Fat Diet on Thiol Disulfide Homeostasis in Rats

“…We have demonstrated previously that high-fat diet (HFD) initiates LPO processes and reduces the antioxidant status [2,3]. Fasting throughout 48 h reduces hepatic glutathione concentration by one-third or by half, while feeding restores its level after several hours [4].…”

Controllable synthesis of NiCo2O4 nanoparticles supported on MnO2 nanowires with excellent oxidase-mimicking performance

“…Therefore, it is significant to reveal their oxidase-like activity and explore their analytical application, such as colorimetric detection. 23 GSH has many important biological functions 24 and plays an important role in many biochemical processes, including redox activity, 25 signal transduction 26 and gene regulation. 27 Moreover, cell health is critically related to the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG).…”