Phospholipids: Unique carriers for drug delivery systems

Singh, Rudra Pratap; Gangadharappa, H.V.; Mruthunjaya, K

doi:10.1016/j.jddst.2017.03.027

Cited by 118 publications

(56 citation statements)

References 95 publications

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“…Phospholipids are a class of lipids that represent a major component of the bilayer of cell membranes . The structure of the phospholipid molecule generally consists of two hydrophobic fatty acid “tails” and a hydrophilic “head” comprising a phosphate group.…”

Section: Phospholipid Synthesismentioning

confidence: 99%

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The relationship between phospholipids and insulin resistance: From clinical to experimental studies

Chang

Hatch

Wang

et al. 2018

J Cellular Molecular Medi

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Insulin resistance induced by high‐fat diet and impropriate life style is a major contributor to the pathogenesis of metabolic disease. However, the underlying molecular mechanisms remain unclear. Recent studies in metabolic dysfunction have extended this beyond simply elevated cholesterol and triglycerides levels and have identified a key role for lipid metabolism. For example, altered phospholipid metabolism has now become central in the pathogenesis of metabolic disease. In this review, we discuss the association between insulin sensitivity and phospholipid metabolism and highlight the most significant discoveries generated over the last several decades. Finally, we summarize the current knowledge surrounding the molecular mechanisms related to phospholipids and insulin resistance and provide new insight for future research into their relationship.

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Section: Phospholipid Synthesismentioning

confidence: 99%

“…Phospholipids are a class of lipids that represent a major component of the bilayer of cell membranes. 12,13 The structure of the phospholipid -…”

Section: Phospholipid Synthesismentioning

confidence: 99%

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

Chang

Hatch

Wang

et al. 2018

J Cellular Molecular Medi

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“…Liposomes are self-assembled NPs made up of phospholipid bilayer membrane. Phospholipids are heterogeneous molecules containing phosphate residues, polar head groups, and non-polar alkyl chains [156] that self-assemble (according to the fluid mosaic model) into biological membranes. Liposomes for brain drug delivery have been studied extensively in the last two decades.…”

Section: Liposomes For Brain Drug Deliverymentioning

confidence: 99%

Peptide based drug delivery systems to the brain

Islam

Leach

Smith³

et al. 2020

Nano Express

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With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers and society at large. In the last two decades, numerous strategies and technologies have been developed and adapted to achieve drug penetration into the brain, evolving alongside our understanding of the physiological barriers between the brain and surrounding tissues. The blood brain barrier (BBB) has been known as the major barrier for drug delivery to the brain. Both invasive and minimally-invasive approaches have been investigated extensively, with the minimallyinvasive approaches to drug delivery being more suitable. Peptide based brain targeting has been explored extensively in the last two decades. In this review paper, we focused on self-assembled peptides, shuttle peptides and nanoparticles drug delivery systems decorated/conjugated with peptides for brain penetration.Abbreviations

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“…This unique composition gives liposomes the capability to carry different types of molecules with different chemical nature. Once the carrier reaches the site of action, it disintegrates and liberates drug molecules as a result of interstitial pressure inside the cancer tissue [27,28]. However, liposomes could remain in circulation for a short period due to rapid elimination via the reticular endothelial system (RES).…”

Section: Types Of Targeting Carriersmentioning

confidence: 99%

The Impact of New Targeting Methods in the Cancer Therapy

2019

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Rapid development has achieved in treating tumor to stop malignant cell growth and metastasis in the past decade. Numerous researches have emerged to increase potency and efficacy with novel methods for drug delivery. The main objective of this literature review was to illustrate the impact of current new targeting methods to other previous delivering systems to select the most appropriate method in cancer therapy. This review first gave a brief summary of cancer structure and highlighted the main roles of targeting systems. Different types of delivering systems have been addressed in this literature review with focusing on the latest carrier derived from malarial protein. The remarkable advantages and main limitations of the later have been also discussed. PubMed and Science Direct were the main search engines that have been used as information sources to prepare this review. Articles related to cancer targeting system, active and passive processes, current nanoparticles, antibody carriers, and current novel cancer carriers were used as sources in this review. Important points from many references published in the last decade (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) were selected and included. Several targeting methods were introduced to enhance the efficacy and tolerability of the toxic drug by active and passive processes, but there is still no conclusive carrier without certain drawbacks. A combination of targeting methods probably shows the most appropriate choice for increasing selectivity and safety of anticancer drugs via reducing the concentration of carriers used. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

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Phospholipids: Unique carriers for drug delivery systems

Cited by 118 publications

References 95 publications

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

The relationship between phospholipids and insulin resistance: From clinical to experimental studies

Peptide based drug delivery systems to the brain

The Impact of New Targeting Methods in the Cancer Therapy

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