Phosphore et bisphosphonates : ou quand on oublie les leçons du passé !

Carrel, Jean-Pierre; Najm, Seeman Abi; Lysitsa, Stella; Lesclous, Philippe; Lombardi, Tommaso; Samson, Jacky

doi:10.1051/mbcb/2006009

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Similarly, phosphorus present in krokodil leads to an alteration of bone metabolism at the cellular level through apoptosis induced by osteoclasts [15]. This hypothesis seems consistent with the pathology of osteonecrosis by exposure to phosphorus found in workers who came into contact with this substance (match industry in the nineteenth and twentieth century) [16]. The risk factors for triggering these necroses would then be the same as those for OCN.…”

Section: Discussionmentioning

confidence: 62%

Krokodil (Desomorphine)-induced osteonecrosis of the maxilla: a case report and literature review

Sergent

Bader

Hamon

et al. 2019

J Oral Med Oral Surg

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Introduction: Desomorphine is an opioid formerly used to treat acute pain. It is simple to manufacture, which has recently led to an increase in its clandestine production under the name “Krokodil”. This article presents a case of oral problems related to its use first ever reported in France. Observation: A 36-year-old male patient presented with bone exposure in sector 1. He admitted to actively consuming “Krokodil IV” for several years. In the course of the clinical and radiological examinations, the patient was diagnosed with osteochemonecrosis of the maxillary induced by krokodil, considering that severe intrinsic and extrinsic adverse effects have been attributed to the drug. Discussion: A systematic literature review was conducted using articles from the Medline and Web of Science databases. To treat such a condition, two authors have described a process consisting of total excision of the necrotic tissue with 0.5 cm margins, combined with discontinuing the intake of the drug. However, these observations should be considered with caution because of the absence of any prospective studies. Conclusion: There are a number of etiologies for osteonecrosis in the context of radiotherapy, intake of bisphosphonates, and administration of bone resorption inhibitors. Unfortunately, in the case of krokodil, its high addictive nature makes it difficult for the patient to wean off the drug. Further, the heterogeneity of its manufacturing make it challenging to pharmacokinetically analyze its prolonged use. In view of the current literature, surgical therapy associated with weaning appears to be the most appropriate treatment, without being able to rule out addiction or necrotic relapses.

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Section: Discussionmentioning

confidence: 62%

Krokodil (Desomorphine)-induced osteonecrosis of the maxilla: a case report and literature review

Sergent

Bader

Hamon

et al. 2019

J Oral Med Oral Surg

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“…En diminuant les phénomènes de résorption osseuse, ils induisent une minéralisation excessive de la trame osseuse [9] . Les BP sont prescrits par voie orale ou par voie intraveineuse [10] . Dans l'ostéoporose et en prévention après pose d'une prothèse de hanche, ils sont prescrits per os.…”

Section: Bisphosphonatesunclassified

Evolution de l’ostéonécrose des maxillaires chez les patients sous bisphosphonates : à propos d’un cas

Rondot

Ejeil

2007

Med Buccale Chir Buccale

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Les indications médicales d'un traitement par bisphosphonates sont nombreuses, en particulier pour le traitement des lésions osseuses de la maladie de Kahler. Cependant il existe des effets secondaires bucco-faciaux de ces médicaments. Le plus largement décrit est l'ostéonécrose des maxillaires. Le cas présenté est celui d'un patient âgé de 92 ans, atteint d'un myélome multiple de stade III. Il consulte initialement pour une gêne causée par le port de son stellite mandibulaire. L'examen endo-buccal révèle la pré-sence d'une érosion muqueuse en « V » sur le versant vestibulaire de la crête alvéolaire mandibulaire antérieure édentée ainsi qu'une ulcération avec exposition osseuse maxillaire postérieure droite. Le patient est traité depuis plus de un an par des cures mensuelles de zolédronate. Ce tableau clinique fait évoquer une ostéo-nécrose liée à l'administration de bisphosphonates. Compte-tenu de l'âge du patient, du contexte médical, et de l'absence de gêne fonctionnelle, une intervention chirurgicale n'est pas proposée. Une antibiothérapie est mise en place, associée à une antisepsie locale. La prothèse mandibulaire est ajustée. L'ostéonécrose progresse néanmoins rapidement, aussi bien au maxillaire qu'à la mandibule.

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Nanotechnologies and controlled release formulations for the administration of bisphosphonates and their potential in radiation protection

Landon,

Phan,

Fay

et al. 2023

Journal of Drug Delivery Science and Technology

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Phosphore et bisphosphonates : ou quand on oublie les leçons du passé !

Cited by 5 publications

References 6 publications

Krokodil (Desomorphine)-induced osteonecrosis of the maxilla: a case report and literature review

Krokodil (Desomorphine)-induced osteonecrosis of the maxilla: a case report and literature review

Evolution de l’ostéonécrose des maxillaires chez les patients sous bisphosphonates : à propos d’un cas

Nanotechnologies and controlled release formulations for the administration of bisphosphonates and their potential in radiation protection

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