Phosphorescent iridium(III) complex for efficient sensing of hypochlorite and imaging in living cells

Liu, Jinsheng; Shangguan, Mingqin; Zeng, Xiaogang; Guo, Yingxiong; Wang, Tao; Hou, Linxi

doi:10.1016/j.ab.2019.113573

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…A conventional approach for designing ClO − detecting probes includes a luminescent signaling unit (iridium), recognition site (ligand), and quencher (C=C, C=N), which controls the phosphorescent intensity of the probes to achieve the detection purpose. A series of “turn on” iridium-based receptors 146 – 150 ( Figure 21 ) tailored with a phosphorescent quencher has been reported in the literature recently [ 151 , 152 , 153 , 154 , 155 ]. Fluorogenic compounds having unbridged C=N and C=C are either weakly fluorescent or non-fluorescent on account of excited state non-radiative decay caused by the isomerization of these bonds.…”

Section: Discussionmentioning

confidence: 99%

Development and Application of Ruthenium(II) and Iridium(III) Based Complexes for Anion Sensing

2023

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Improvements in the design of receptors for the detection and quantification of anions are desirable and ongoing in the field of anion chemistry, and remarkable progress has been made in this direction. In this regard, the development of luminescent chemosensors for sensing anions is an imperative and demanding sub-area in supramolecular chemistry. This decade, in particular, witnessed advancements in chemosensors based on ruthenium and iridium complexes for anion sensing by virtue of their modular synthesis and rich chemical and photophysical properties, such as visible excitation wavelength, high quantum efficiency, high luminescence intensity, long lifetimes of phosphorescence, and large Stokes shifts, etc. Thus, this review aims to summarize the recent advances in the development of ruthenium(II) and iridium(III)-based complexes for their application as luminescent chemosensors for anion sensing. In addition, the focus was devoted to designing aspects of polypyridyl complexes of these two transition metals with different recognition motifs, which upon interacting with different inorganic anions, produces desirable quantifiable outputs.

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Section: Discussionmentioning

confidence: 99%

Development and Application of Ruthenium(II) and Iridium(III) Based Complexes for Anion Sensing

2023

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“…Hou and co-workers have developed iridium(III) complexes modified with two tosylhydrazone (439) 828 or isoniazide moieties (440) 829 (Chart 196) for visualizing HClO in live cells. The presence of HClO induces oxidative hydrolysis of the hydrazone linkage, leading to a rapid and substantial increase in the emission intensities of the complexes.…”

Section: •−mentioning

confidence: 99%

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d 6 , d 8 , and d 10 electronic configuration. We elucidate the structure−property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

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“…[40] Modification of [Ir(ppy) 2 (bpy)] + with two tosylhydrazone moieties gives complex 23 for visualizing HOCl in live cells. [42] The complex displays a 21-fold increase in the emission intensity at 574 nm within 15 s upon the addition of HOCl, which is due to the oxidative hydrolysis of the tosylhydrazone unit to an aldehyde moiety (Scheme S6c).…”

Section: Hypochlorous Acidmentioning

confidence: 99%

Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity‐Based Probes for Bioimaging and Biosensing

Lee

2022

Chemistry An Asian Journal

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The rapid development of responsive fluorescent probes has advanced optical imaging for biological research and biomedical applications. Among different sensing strategies, activity-based sensing, which exploits the unique reactivity of the target chemical species to achieve high chemoselectivity, has emerged as a promising paradigm for the development of responsive probes for selective molecular imaging. Luminescent transition metal complexes have received considerable attention for bioimaging and biosensing applications over the last decade due to their remarkable photophysical behavior including intense emission with large Stokes' shifts, long emission lifetimes, strong two-photon absorption, and high photostability. In this Review, we summarize the design strategies and applications of luminescent complexes of rhenium(I), ruthenium(II), and iridium(III) polypyridines as activity-based probes for the detection of various chemical species and bioactive molecules in live cells and organisms. The current challenges and future prospects of these complexes as activatable reagents for disease diagnosis and treatment are also discussed.

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Phosphorescent iridium(III) complex for efficient sensing of hypochlorite and imaging in living cells

Cited by 8 publications

References 35 publications

Development and Application of Ruthenium(II) and Iridium(III) Based Complexes for Anion Sensing

Development and Application of Ruthenium(II) and Iridium(III) Based Complexes for Anion Sensing

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Strategic Design of Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Complexes as Activity‐Based Probes for Bioimaging and Biosensing

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