Phosphorus as an early marker of morbidity and mortality in type 2 chronic kidney disease diabetic patients

Silva, Ana Paula; André, Fabrice; Pinho, Ana; Tavares, Nélson; Camacho, Ana; Faísca, Marília; Neves, Pedro Leão

doi:10.1016/j.jdiacomp.2013.02.007

Cited by 13 publications

(11 citation statements)

References 18 publications

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“…This study, and similarly to other independent studies conducted by the authors [30,31], bring new input to the diversified puzzle of upcoming variables other than traditional and non-traditional cardiovascular risk factors, that can possibly be translated and clinically used as predictors of mortality in earlier stages of CKD.…”

Section: Discussionsupporting

confidence: 56%

Magnesium and Mortality in Patients with Diabetes and Early Chronic Kidney Disease

Silva¹

2014

J Diabetes Metab

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Subjects and Methods An observational, prospective study involving 191 patients was conducted in our outpatient diabetic nephropathy clinic from December 2007 to May 2013. The study was submitted to and approved by the administration and ethics committee. The study was conducted according to the principles of the Declaration of Helsinki, and study procedures were only performed after signing the informed consent.

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Section: Discussionsupporting

confidence: 56%

Magnesium and Mortality in Patients with Diabetes and Early Chronic Kidney Disease

Silva¹

2014

J Diabetes Metab

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“…[ 48 ] This can produce a vicious cycle and further aggravate cell death. In fact, a number of studies have shown that patients with increased phosphate levels are more likely to develop cardiovascular diseases [ 47 , 49 , 50 ] and chronic kidney disease, [ 51 ] even end-stage renal disease. [ 51 ]…”

Section: Discussionmentioning

confidence: 99%

Electrolyte and mineral disturbances in septic acute kidney injury patients undergoing continuous renal replacement therapy

et al. 2016

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“…Thus, hyperphosphatemia is considered to be an important marker of cardiovascular morbidity and mortality in patients with CKD. 28 , 30 Interestingly, higher phosphorus levels that are within normal range are significantly associated with coronary infarction or coronary death even in patients with normal kidney function. 31 Therefore, we believe that choroidal thinning in naïve eyes with severe NPDR or PDR can suggest or predict vascular calcifications of the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Effects of Systemic Profiles on Choroidal Thickness in Treatment-Naïve Eyes With Diabetic Retinopathy

Choi

Chung

Yoon

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to analyze the effects of systemic and ocular profiles on subfoveal choroidal thickness (SFChT) in treatment-naïve eyes with diabetic retinopathy (DR). Methods This study included patients with treatment-naïve DR. They underwent routine laboratory evaluations, including complete blood cell count, liver function tests, kidney function tests, and urinalysis for macroalbuminuria. The systemic and ocular factors associated with the change in SFChT in DR were analyzed. Results A total of 136 eyes from 136 patients with diabetes and 30 eyes from 30 age-matched healthy controls were recruited. Generalized linear model analyses showed that the SFChT in treatment-naïve eyes with DR was positively associated with the DR grade and estimated glomerular filtration rate (eGFR; P = 0.001) and negatively associated with age ( P < 0.001) and serum phosphorus levels ( P = 0.001). Treatment-naïve eyes with proliferative DR (PDR; 313.4 ± 9.0 µm) or severe nonproliferative DR (NPDR; 299.7 ± 9.7 µm) had thicker choroid than eyes with mild to moderate NPDR (251.7 ± 11.1 µm) or no DR (231.2 ± 14.5 µm) after adjusting for age, eGFR, and phosphorus levels. Conclusions Choroid is affected by renal function and the grade of DR in patients with diabetes. Advanced retinopathy is associated with choroidal thickening, and the severity of concomitant renal disease is associated with choroidal thinning.

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Phosphorus as an early marker of morbidity and mortality in type 2 chronic kidney disease diabetic patients

Cited by 13 publications

References 18 publications

Magnesium and Mortality in Patients with Diabetes and Early Chronic Kidney Disease

Magnesium and Mortality in Patients with Diabetes and Early Chronic Kidney Disease

Electrolyte and mineral disturbances in septic acute kidney injury patients undergoing continuous renal replacement therapy

Effects of Systemic Profiles on Choroidal Thickness in Treatment-Naïve Eyes With Diabetic Retinopathy

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