Phosphorus Metabolism in Normal, Rachitic and Treated Rats

Dols, M. J. L.; Jansen, Boris; Sizoo, G.J.; Vries, J. de

doi:10.1038/1391068a0

Cited by 19 publications

(3 citation statements)

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“…Chievitz & Hevesy [1937] and Dols et al [1937] did not find any outstanding difference in the distribution of radio-P in rachitic and normal rats. Dols et al [1938b] found a higher content of radio-P in the bones of rachitic chickens than in those of normal birds.…”

Section: Discussionmentioning

confidence: 99%

“…Chievitz & Hevesy [1937], Dols, Jansen, Sizoo & de Vries [1937], Dols, Jansen, Sizoo & van der Maas [1938b] and Cohn & Greenberg [1939] have reported the findings with rachitic animals, both before and after vitamin D medication. However, no investigation appears to have been made of the changes in the detailed distribution of radio-P in the body when given to animals after subjection to mild P deprivation for several weeks.…”

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confidence: 87%

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The assimilation of radio‐active phosphorus deficiency in rats

Gaunt¹,

Griffith²,

Irving³

1942

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

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confidence: 87%

The assimilation of radio‐active phosphorus deficiency in rats

Gaunt¹,

Griffith²,

Irving³

1942

The Journal of Physiology

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“…[1931], P absorption being secondarily improved. Workers with radio-P have not, however, found that vitamin D had any effect upon P absorption [Dols, Jansen, Sizoo & de Vries, 1937;Morgareide' & Manly, 1939] and in addition the latter workers objected that vitamin D could not act solely by improving intestinal absorption, as the time of its action would not allow of this. After the addition of P to a high Ca: P ratio diet, healing is detectable within 12 hr.…”

Section: Vitamin D and The Teethmentioning

confidence: 99%

The action of vitamin d upon the incisor teeth of rats consuming diets with a high or low ca:p ratio

Irving¹

1944

The Journal of Physiology

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Vitamin D is one of the factors essential for the proper formation of teeth, and in its absence the same changes are seen that occur in lack of Ca and P. The constantly developing incisor tooth of the rat is a very convenient object for studying the effects of vitamin D upon both the teeth and the body generally, as any change in Ca or P metabolism is immediately reflected in the appearance of the dentin, Erdheim [1911] having aptly compared the rat's incisor with the drum of a kymograph.The effects of massive doses of the vitamin upon the normal rat's incisor have been described by Schour & Ham [1934] and after parathyroidectomy by Schour, Tweedy, Chandler & Engel [1937]. In both instances, the dentin showed a hypocalcified stripe followed by a reactive hypercalcified zone. Downs [1932] described the effects of vitamin D upon the teeth of rats on diets with various Ca: P ratios. The vitamin was incorporated into the diets and thus the effect was prophylactic. He came to the rather unexpected conclusion that the vitamin acted deleteriously with diets with a lowered P content, causing the histological changes to be more marked, but with diets with a lowered Ca content the vitamin acted beneficially.The reaction of the tooth to curative doses of vitamin D after the establishment of well-marked dietary rickets does not, however, appear to have been followed. In the present.paper the effects of the vitamin upon the teeth of rats with rickets caused by diets with abnormally high or low Ca: P ratios are described. Preliminary reports of some of the findings have already been published [Irving, 1941[Irving, , 1943. METHODS AnimalsAlbino rats of the Wistar Institute strain were kept in a special animal house at a temperature of 68-70°. Males and females were used indiscriminately, the results found being the same in both sexes. After weaning at 25 days, the

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Ardenne¹

1944

Die Physikalischen Grundlagen Der Anwendung Radioaktiver Oder Stabiler Isotope Als Indikatoren

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Phosphorus Metabolism in Normal, Rachitic and Treated Rats

Cited by 19 publications

References 2 publications

The assimilation of radio‐active phosphorus deficiency in rats

The assimilation of radio‐active phosphorus deficiency in rats

The action of vitamin d upon the incisor teeth of rats consuming diets with a high or low ca:p ratio

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