Phosphorus–nitrogen compounds: Part 31. Syntheses, structural and stereogenic properties, in vitro cytotoxic and antimicrobial activities, and DNA interactions of bicyclotetraphosphazenes containing bulky side group

The Syntheses and Structural Characterizations, Antimicrobial Activity and in Vitro Dna Binding of 4-Fluorobenzylspiro(n/O)cyclotriphosphazenes and Their Phosphazenium Salts

“…Some of the cyclotriphosphazene derivatives are used as liquid crystals [7,8], rechargeable lithium-ion batteries [9,10], OLEDs [11,12], and lubricants [13,14]. It is found that aminocyclophosphazene derivatives have antimicrobial activity against bacteria and fungi [15][16][17]. The interactions between DNA and the phosphazene derivatives have also been investigated in the two last decades [18,19].…”

Syntheses and spectroscopic investigations of 2-pyridyl(N/N)spirocyclotriphosphazenes

“…In such a manner, that some of the cyclophosphazenes were also found to be active in the different tumor cells; e.g. Hep2, HT-29, Hela, C6, Vero, DLD1 and A549 cells (22)(23)(24).…”

Phosphorus-nitrogen compounds- (Part 50): correlations between structuralparameters for cylophosphazene derivatives containing ferrocenyl pendant arm(s)

“…Especially, hexachlorocyclotriphosphazene (N 3 P 3 Cl 6 , trimer) and octachlorocyclotetraphosphazene (N 4 P 4 Cl 8 , tetramer) are of particular interest to both theoretical and experimental researchers concerning phosphazene-based chemistry. Because of their tendency to react with the nucleophilic mono-, di-, or multi-functional groups [3][4][5][6], both of the cyclophosphazenes were used in the syntheses of a considerable range of organocyclotri/tetraphosphazene derivatives with diverse applications [7,8]. The substantial efforts have been performed on the nucleophilic substitution reactions, in which the 1-to 6-Cl-atoms on trimer and 1-to 8-Cl atoms on tetramer have been replaced by the NH and/or OH functioned reagents, forming isomeric products e.g., structural (spiro-, ansa-and bino-architectures or a mixed of the same or different architectures), geometrical (geminal, non-geminal cis/trans-), and optical isomers [9,10].…”

“…According to these studies, it was observed that geminal vanillinato (Van)-substituted spiro-monoferrocenyl cyclotriphosphazenes [31], tetra pyrrolidine (Pyr)-substituted spiro-mono [32,33] and bisferrocenyl [33] cyclotriphosphazenes and hexa Pyr-substituted spiro-monoferrocenyl cyclotetraphosphazenes [34] inhibited the growth of Mycobacterium tuberculosis H37Rv. While 1,4-dioxa-8-azaspiro [4,5]decane (DASD)-substituted spiro-bisferrocenyl [35] and partly substituted dispiro-bisferrocenyl [36] cyclotriphosphazenes, the fully and nongeminal (cis) [37] Van-substituted spiro-monoferrocenyl cyclotriphosphazenes, were effective against the human cervical cancer cell line (HeLa), bis(diamino) substituted dispiro-bisferrocenyl cyclotetraphosphazene was found to be more active against colon cancer DLD-1 cells than Doxorubicin [38]. It was also found that the DASD and Pyr-substituted ferrocenyl cyclotriphosphazenes were active against some gram-positive and gram-negative bacteria [32,33,35] and Pyrsubstituted ferrocenyl cyclotetraphosphazenes were more effective than the commercial antifungal drug Ketoconazole against fungi [34].…”