Syntheses and spectroscopic investigations of 2-pyridyl(N/N)spirocyclotriphosphazenes

Abstract

The Cl substitution reaction of N3P3Cl6 (1) with N-(2-pyridyl)-methyl-N'methylpropane-1,3-diamine (2) afforded the partly substituted 2pyridyl(N/N)spirocyclotriphosphazene (3) (with a yield of 57%) in dry THF. When the Cl replacement reactions of 2 carried out with excess pyrrolidine, morpholine, and 1,4-dioxa-8-azaspiro[4,5]decane (DASD), the corresponding 2-pyridyl(N/N)spirotetrapyrrolidino (3a), tetramorpholino (3b) and tetra(1,4-dioxa-8-azaspiro[4,5]decano) (3c) cyclotriphosphazenes were prepared in moderate yields. The structures of four cyclotriphosphazene derivatives were elucidated by the elemental analyses, Fourier transform infrared (FTIR), heteronuclear mass spectrometry (ESI-MS), heteronuclear multiple-bond correlation (HMBC), single quantum coherence (HSQC), 1 H, 13 C, and 31 P NMR techniques.

Phosphorus–nitrogen compounds: part 70. Syntheses of tetraaminomono/bis(4-fluorobenzyl)spiro(N/N)cyclotriphosphazenes: structural characterization, Hirshfeld surface analysis and comparative evaluation of esterase activities of hCA I and hCA II isoenzymes

“…vibrations of P–Cl bonds given in the literature 37 in starting compounds ( 1 and 2 ) do not appear in the spectra of mono/bis products containing tetraamino groups. 45 The ν asymm. and ν symm.…”