Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl

Zhu, Jinwei; Shang, Yuan; Wan, Qingwen; Xia, Yitian; Chen, Jia; Du, Quansheng; Zhang, Mingjie

doi:10.1038/cr.2014.16

Cited by 58 publications

(67 citation statements)

References 37 publications

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“…Lgl contains a number of WD-40 repeat domains as well as conserved phosphorylation sites. Each of the polarity proteins are structurally highly conserved in all metazoa Dlg and Lgl (Zhu et al 2014). Importantly, the Dlg interaction with Lgl is regulated and requires phosphorylation of one of the three conserved Serine residues of the central linker region of Lgl (Zhu et al 2014).…”

Section: Sh3 Domainmentioning

confidence: 99%

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

et al. 2015

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Section: Sh3 Domainmentioning

confidence: 99%

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

et al. 2015

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“…The Scribble complex is distinct from the Par and Crumbs complexes in that, although there are clearly strong genetic interactions, there is limited evidence for physical interactions. One study shows binding of Dlg to phosphorylated Lgl (Zhu et al, 2014), another shows that the adapter protein GUK-holder is required for interaction between Scrib and Dlg (Mathew et al, 2002). Recent evidence indicates that an additional basolateral complex consists of yurt, coracle, neurexin IV and the Na + /K + ATPase (Laprise et al, 2009).…”

Section: Modular Protein Complexes Establish Apical/basal Polaritymentioning

confidence: 99%

Development and dynamics of cell polarity at a glance

Campanale

Sun

Montell

2017

Journal of Cell Science

179

162

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Cells exhibit morphological and molecular asymmetries that are broadly categorized as cell polarity. The cell polarity established in early embryos prefigures the macroscopic anatomical asymmetries characteristic of adult animals. For example, eggs and early embryos have polarized distributions of RNAs and proteins that generate global anterior/posterior and dorsal/ventral axes. The molecular programs that polarize embryos are subsequently reused in multiple contexts. Epithelial cells require apical/basal polarity to establish their barrier function. Migrating cells polarize in the direction of movement, creating distinct leading and trailing structures. Asymmetrically dividing stem cells partition different molecules between themselves and their daughter cells. Cell polarity can develop de novo, be maintained through rounds of cell division and be dynamically remodeled. In this Cell Science at a Glance review and poster, we describe molecular asymmetries that underlie cell polarity in several cellular contexts. We highlight multiple developmental systems that first establish cell/developmental polarity, and then maintain it. Our poster showcases repeated use of the Par, Scribble and Crumbs polarity complexes, which drive the development of cell polarity in many cell types and organisms. We then briefly discuss the diverse and dynamic changes in cell polarity that occur during cell migration, asymmetric cell division and in planar polarized tissues.

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“…Moreover, recent findings have suggested that the lateral polarity factor Lethal (2) giant larvae (Lgl) is involved in a regulatory step that controls this interaction. Like Pins, Lgl can bind to the GUK domain of Dlg in vitro (Zhu et al, 2014). In the Drosophila follicular epithelium and imaginal wing disc, Lgl is cortical during interphase but becomes cytoplasmic at mitosis, a switch that is triggered by its phosphorylation by Aurora kinases (Bell et al, 2015;Carvalho et al, 2015).…”

Section: Dlg Can Provide a Cortical Cue For Pinsmentioning

confidence: 99%

Spindle orientation: a question of complex positioning

2017

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The direction in which a cell divides is determined by the orientation of its mitotic spindle at metaphase. Spindle orientation is therefore important for a wide range of developmental processes, ranging from germline stem cell division to epithelial tissue homeostasis and regeneration. In multiple cell types in multiple animals, spindle orientation is controlled by a conserved biological machine that mediates a pulling force on astral microtubules. Restricting the localization of this machine to only specific regions of the cortex can thus determine how the mitotic spindle is oriented. As we review here, recent findings based on studies in tunicate, worm, fly and vertebrate cells have revealed that the mechanisms for mediating this restriction are surprisingly diverse.

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Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl

Cited by 58 publications

References 37 publications

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

Development and dynamics of cell polarity at a glance

Spindle orientation: a question of complex positioning

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