2012
DOI: 10.1371/journal.ppat.1002521
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Phosphorylcholine Allows for Evasion of Bactericidal Antibody by Haemophilus influenzae

Abstract: The human pathogen Haemophilus influenzae has the ability to quickly adapt to different host environments through phase variation of multiple structures on its lipooligosaccharide (LPS), including phosphorylcholine (ChoP). During colonization with H. influenzae, there is a selection for ChoP+ phase variants. In a murine model of nasopharyngeal colonization, this selection is lost in the absence of adaptive immunity. Based on previous data highlighting the importance of natural antibody in limiting H. influenza… Show more

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Cited by 66 publications
(77 citation statements)
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“…ChoP modification is important for NTHI colonization and persistence in AOM because of roles in biofilm formation, adherence to cells through the PAF receptor, survival of complement-mediated lysis, as well as resistance to antimicrobial peptides (121)(122)(123)(124)(125)(126)(127). The significant reduction of PC derivatives could be because of decreases in biosynthesis or use as a preferential substrate for glycan modification by NTHI.…”
Section: Discussionmentioning
confidence: 99%
“…ChoP modification is important for NTHI colonization and persistence in AOM because of roles in biofilm formation, adherence to cells through the PAF receptor, survival of complement-mediated lysis, as well as resistance to antimicrobial peptides (121)(122)(123)(124)(125)(126)(127). The significant reduction of PC derivatives could be because of decreases in biosynthesis or use as a preferential substrate for glycan modification by NTHI.…”
Section: Discussionmentioning
confidence: 99%
“…The AI45dup-containing mutant was completely avirulent in a mouse model of sepsis. In addition to C3 complement-mediated opsonophagocytic killing, high concentrations of C-reactive protein (CRP) found in the blood can bind exposed P-Cho residues present in the AI45dup-containing strain and initiate the classical complement cascade, likely resulting in complete clearance of the mutant (51,70).…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, the level of virulence of some pathogenic bacteria is determined by phase or antigenic variation (441). Moreover, thanks to this variation, bacteria residing in an organism can evade host innate and acquired immune mechanisms (442) and avoid being targeted by cross-immunity (443). These escapes increase the duration of infection and, hence, the chances of spreading the bacteria to new hosts, as well as facilitating chronic infections and allowing several successive colonization events of the same host by similar bacterial strains.…”
Section: Consequences Of Genome Instability In Bacteria Phase and Antmentioning
confidence: 99%