Photic induction and circadian expression of Fos-like protein. Immunohistochemical study in the retina and suprachiasmatic nuclei of hamster

Chambille, Irène; Doyle, Susan E.; Servière, Jacques

doi:10.1016/0006-8993(93)91654-b

Cited by 82 publications

(43 citation statements)

References 41 publications

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“…This was confirmed quantitatively: in split hamsters, the area of antiphase pERK expression was ϳ45,000 m 2 , much larger than the ϳ23,000 m 2 in the controls. c-FOS, pERK, and PER1 were all rhythmic, but they were not simultaneously expressed, consistent with previous reports (Chambille et al, 1993;Guido et al, 1999;Field et al, 2000;Lee et al, 2003a). At 3 h after activity onset, c-FOS was high on the side contralateral to high PER1, whereas at 9 h after activity onset, it was high on the same side as PER1 for both core-and shell-like areas.…”

Section: Resultssupporting

confidence: 90%

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Two Antiphase Oscillations Occur in Each Suprachiasmatic Nucleus of Behaviorally Split Hamsters

Yan¹,

Foley²,

Bobula³

et al. 2005

J. Neurosci.

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The suprachiasmatic nuclei (SCNs) control circadian rhythms of numerous behavioral and physiological responses. In hamsters, constant light causes "splitting" of circadian rhythms, such that a single daily bout of activity separates into two components, 12 h apart, with antiphase circadian oscillations in the left and right SCN. Given the phenotypic and functional heterogeneity of the SCN, in which ventrolateral but not dorsomedial neurons are retinorecipient, we asked how these two compartments respond to the constant lighting conditions that produce splitting, using three different phase markers of neuronal activity: PER1 (Period 1), c-FOS, and pERK (phosphorylated extracellular signal-regulated kinase). We report the emergence of a coherent novel network in which each side of the SCN exhibits two antiphase oscillating subregions, here termed "core-like" and "shell-like," in addition to the known antiphase oscillation between the right and left SCN. The novel SCN response entails a coherent rhythm in a core-like region of the SCN, which otherwise is not cycling. A mathematical model is presented, and this model interprets the observed changes in the proportion of in-phase and antiphase populations of SCN oscillators and suggests novel testable hypotheses. Finally, the functional significance of this network was explored by investigating the adjacent hypothalamus. Activation of the paraventricular nucleus is in-phase with the ipsilateral core-like SCN, whereas activation of the lateral subparaventricular zone is in-phase with the ipsilateral shell-like SCN, pointing to a multiplicity of SCN output signals. These results suggest a neural basis for internal coincidence of SCN oscillators, and a novel mechanism of plasticity in SCN neural networks and outputs.

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Section: Resultssupporting

confidence: 90%

“…The same results were observed in all animals killed at this time point. c-FOS expression is high during the day and low during the night in the SCN shell (Chambille et al, 1993;present study). This was used to assign the right and left SCN of the split animal to its appropriate time of day of either CT3 or CT15.…”

Section: Resultsmentioning

confidence: 50%

Two Antiphase Oscillations Occur in Each Suprachiasmatic Nucleus of Behaviorally Split Hamsters

Yan¹,

Foley²,

Bobula³

et al. 2005

J. Neurosci.

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“…This property is of great importance, because it offers a valuable tool for morphofunctional identification of activated neurons (Kaczmarek, 2002). c-Fos induction by light has been mostly studied in rats, mice, rabbits and hamsters, in the suprachiasmatic nucleus in relation to changes of general illumination and circadian rhythms (Rea, 1989;Aronin et al, 1990;Rusak et al, 1990;Chambille et al, 1993;Earnest and Olschowka, 1993;Vuillez et al, 1994); in response to global flashes of light in the retina and central visual pathways Craner et al, 1992;Koistinaho et al, 1993) and after pattern visual stimulation (Yoshida et al, 1993;Montero and Jian, 1995;Harada et al, 1996;Bussolino et al, 1998;CorreaLacarcel et al, 2000;Lima et al, 2003). Sagar et al (1988), in order to determine whether the c-Fos protein and Fos-related proteins can be induced in response to polysynaptic activation, stimulated electrically the rat hindlimb motor/sensory cortex and examined the Fos expression immunohistochemically.…”

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confidence: 99%

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Poveda¹,

Kretz²

2009

Journal of Chemical Neuroanatomy

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“…Most studies showing no rhythm in vlSCN c-Fos under constant darkness, do however report c-Fos expression in dmSCN (Chambille et al, 1993;Guido et al, 1999;Schwartz et al, 2000), but Colwell & Foster (1992) report almost no C-FOS in the whole SCN of the mouse under DD. In the vole we see low levels of C-FOS rhythms in the dmSCN, but no rhythmicity after a prolonged duration in constant light.…”

Section: Llmentioning

confidence: 93%

“…In the dmSCN, in DD, c-Fos peptide and mRNA are reported to peak at the time of previous lights on, or a few hours later (Sumová et al, 1998(Sumová et al, , 2005Guido et al, 1999;Schwartz et al, 2000). Alternatively, a peak in C-FOS expression in the dmSCN is reported at 7 h into the subjective day (Chambille et al, 1993). Several reports state that no circadian rhythm in vlSCN c-Fos peptide or mRNA expression is seen under constant dark conditions (Schwartz et al, 1994;Sumová et al, 1998Sumová et al, , 2000Sumová et al, , 2005.…”

Section: C-fos Under Constant Lighting Conditionsmentioning

confidence: 99%

Circadian Rhythms of C‐FOS Expression in the Suprachiasmatic Nuclei of the Common Vole (Microtus arvalis)

Veen

Pol-Meijer

Jansen

et al. 2008

Chronobiology International

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The suprachiasmatic nuclei of the hypothalamus (SCN) are the master circadian clock in mammals. Transcriptional activity in this master clock has a marker in the immediate-early gene c-Fos. Within the SCN, distinct differences in c-Fos in the ventrolateral and the dorsomedial SCN have been reported for rodent species such as rats, mice and hamsters.We studied C-FOS expression in the Common vole (Microtus arvalis) SCN under LD 12:12h and under constant dim light conditions. In the vole dorsomedial SCN rhythmic C-FOS expression was seen in LD with a clear peak in the middle of the light period. Under constant dim light conditions we report constitutive, non-rhythmic expression of C-FOS in the dorsomedial SCN. This pattern is consistent with circadian organization of behavioral activity, which is weak in voles, and may be lost under constant dim light conditions. In the ventrolateral SCN, under LD conditions we observed a rise in C-FOS expression prior to lights-on followed by peak expression at lights-on. Another peak was seen at lights-off. In an additional experiment we subjected animals to LD 16:8 to test the hypothesis that the dawn and dusk peaks in ventrolateral C-FOS expression change phase along with the photoperiod.

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Photic induction and circadian expression of Fos-like protein. Immunohistochemical study in the retina and suprachiasmatic nuclei of hamster

Cited by 82 publications

References 41 publications

Two Antiphase Oscillations Occur in Each Suprachiasmatic Nucleus of Behaviorally Split Hamsters

Two Antiphase Oscillations Occur in Each Suprachiasmatic Nucleus of Behaviorally Split Hamsters

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Circadian Rhythms of C‐FOS Expression in the Suprachiasmatic Nuclei of the Common Vole (Microtus arvalis)

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