Photo-activated autophagy-associated tumour cell death by lysosome impairment based on manganese-doped graphene quantum dots

Liang, Qingjing; Yu, Feng; Cai, Hao; Wu, Xiaoyan; Ma, Menghui; Li, Zijian; Tedesco, Antônio Cláudio; Zhu, Jiang; Xu, Qian; Hong, Bo

doi:10.1039/d2tb02761e

Cited by 14 publications

(6 citation statements)

References 43 publications

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“…This activated the autophagy-associated cell death via elevated production of autophagosomes and autolysosomes and also enhanced the apoptosis and ferroptosis inside the SH-SY5Y 3D multicellular spheroid. 50 Poly[2-methoxy-5-(2 0 -ethylhexyloxy)-1,4-phenylene vinylene] (MEH-PPV), IR780, and polyethylenimine (PEI) were applied for the fabrication of a semiconducting polymer, which was then functionalized with GQDs with intrinsic enzyme-like activity. Indeed, GQDs have peroxidase (POD)-like activity and could generate hydroxyl radicals ( OH).…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

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Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies

Zarepour,

Khosravi,

Yücel Ayten

et al. 2024

J. Mater. Chem. B

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Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Section: Gqds In Cancer Therapymentioning

confidence: 99%

Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies

Zarepour,

Khosravi,

Yücel Ayten

et al. 2024

J. Mater. Chem. B

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“…As a result, this leads to the death of cancer cells through precise autophagy dysfunction caused by lysosome impairment. 59 …”

Section: Graphene and Graphene Derivatives In Oncologymentioning

confidence: 99%

“…Moreover, Mn-FGQDs are structurally robust and retain their high photodynamic efficiency in the lysosomal environment. [ 59 ] CPT-MrGO-AA-g-4-HC MCF-7 and WS-1 The cytotoxic effects of CPT and 4-HC loaded carriers show higher toxicity effect against the human breast cancer cell line (MCF-7) compared with the normal fibroblast cell line (WS-1). [ 98 ] UCNP@GQD HeLa This new type photodynamic therapy (PDT) produced ROS efficiently under near-infrared light excitation.…”

Section: Summary and Future Perspectivementioning

confidence: 99%

Chasing Graphene-Based Anticancer Drugs: Where are We Now on the Biomedical Graphene Roadmap?

Uzdrowska,

Knap,

Gulczynski

et al. 2024

IJN

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Graphene and graphene-based materials have attracted growing interest for potential applications in medicine because of their good biocompatibility, cargo capability and possible surface functionalizations. In parallel, prototypic graphene-based devices have been developed to diagnose, imaging and track tumor growth in cancer patients. There is a growing number of reports on the use of graphene and its functionalized derivatives in the design of innovative drugs delivery systems, photothermal and photodynamic cancer therapy, and as a platform to combine multiple therapies. The aim of this review is to introduce the latest scientific achievements in the field of innovative composite graphene materials as potentially applied in cancer therapy. The “Technology and Innovation Roadmap” published in the Graphene Flagship indicates, that the first anti-cancer drugs using graphene and graphene-derived materials will have appeared on the market by 2030. However, it is necessary to broaden understanding of graphene-based material interactions with cellular metabolism and signaling at the functional level, as well as toxicity. The main aspects of further research should elucidate how treatment methods (e.g., photothermal therapy, photodynamic therapy, combination therapy) and the physicochemical properties of graphene materials influence their ability to modulate autophagy and kill cancer cells. Interestingly, recent scientific reports also prove that graphene nanocomposites modulate cancer cell death by inducing precise autophagy dysfunctions caused by lysosome damage. It turns out as well that developing photothermal oncological treatments, it should be taken into account that near-infrared-II radiation (1000–1500 nm) is a better option than NIR-I (750–1000 nm) because it can penetrate deeper into tissues due to less scattering at longer wavelengths radiation.

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“…Because cytotoxicity research can pre-determine the potential toxicity of QDs and the existing mechanism of drug production before animal exposure, it is very important to study the cytotoxicity of QDs. Previous studies have found that QDs caused different degrees of cytotoxicity, such as decreasing cell viability 56 , altering cell morphology, 57 , 58 inducing autophagy, 59 , 60 and inducing cells to produce living oxygen substances 61 and changing the expression of genes 62 and so on.…”

Section: In Vivo Toxicity Of Qdsmentioning

confidence: 99%

A Review of in vivo Toxicity of Quantum Dots in Animal Models

Lin,

Chen

2023

IJN

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Tremendous research efforts have been devoted to nanoparticles for applications in optoelectronics and biomedicine. Over the past decade, quantum dots (QDs) have become one of the fastest growing areas of research in nanotechnology because of outstanding photophysical properties, including narrow and symmetrical emission spectrum, broad fluorescence excitation spectrum, the tenability of the emission wavelength with the particle size and composition, anti-photobleaching ability and stable fluorescence. These characteristics are suitable for optical imaging, drug delivery and other biomedical applications. Research on QDs toxicology has demonstrated QDs affect or damage the biological system to some extent, and this situation is generally caused by the metal ions and some special properties in QDs, which hinders the further application of QDs in the biomedical field. The toxicological mechanism mainly stems from the release of heavy metal ions and generation of reactive oxygen species (ROS). At the same time, the contact reaction with QDs also cause disorders in organelles and changes in gene expression profiles. In this review, we try to present an overview of the toxicity and related toxicity mechanisms of QDs in different target organs. It is believed that the evaluation of toxicity and the synthesis of environmentally friendly QDs are the primary issues to be addressed for future widespread applications. However, considering the many different types and potential modifications, this review on the potential toxicity of QDs is still not clearly elucidated, and further research is needed on this meaningful topic.

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Photo-activated autophagy-associated tumour cell death by lysosome impairment based on manganese-doped graphene quantum dots

Abstract: Autophagy is indispensable in normal cellular processes, yet detrimental for cancer treatment because it severely lowers the therapy efficiency. One of the keys to solving this problem may lie in...

Cited by 14 publications

References 43 publications

Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies

Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies

Chasing Graphene-Based Anticancer Drugs: Where are We Now on the Biomedical Graphene Roadmap?

A Review of in vivo Toxicity of Quantum Dots in Animal Models

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