Photo-click crosslinked hydrogel containing MgO2-loaded PLGA microsphere with concurrent magnesium and oxygen release for bone tissue engineering

Nasrollah, Seyyed Ahmad Seyyed; Karimi‐Soflou, Reza; Karkhaneh, Akbar

doi:10.1016/j.mtchem.2023.101389

Cited by 8 publications

(3 citation statements)

References 59 publications

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“…The hydrogel displayed a controlled release of magnesium (13-22 mg l −1 ) and oxygen (7.7-8.2 mg l −1 ) over 14 d. Viability and adhesion of cells were appropriate, as evidenced by MTT and live/dead assays. Human adipose-derived MSCs cultured on these hydrogels showed osteogenic differentiation, expressing alkaline phosphatase (ALP), osteocalcin, and osteopontin after 21 d. This study suggested that the prepared hydrogels were well-suited for osteogenic differentiation and BTE [117].…”

Section: Bone Tissue Engineeringmentioning

confidence: 86%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile biomaterials in the biomedical domain. GelMA hydrogels emulate vital characteristics of the innate extracellular matrix (ECM) by integrating cell-adhering and matrix metalloproteinase-responsive peptide motifs. These features enable cellular proliferation and spreading within GelMA-based hydrogel scaffolds. Moreover, GelMA displays flexibility in processing, as it experiences crosslinking when exposed to light irradiation, supporting the development of hydrogels with adjustable mechanical characteristics. The drug delivery landscape has been reshaped by GelMA hydrogels, offering a favorable platform for the controlled and sustained release of therapeutic actives. The tunable physicochemical characteristics of GelMA enable precise modulation of the kinetics of drug release, ensuring optimal therapeutic effectiveness. In tissue engineering, GelMA hydrogels perform an essential role in the design of the scaffold, providing a biomimetic environment conducive to cell adhesion, proliferation, and differentiation. Incorporating GelMA in three-dimensional printing further improves its applicability in drug delivery and developing complicated tissue constructs with spatial precision. Wound healing applications showcase GelMA hydrogels as bioactive dressings, fostering a conducive microenvironment for tissue regeneration. The inherent biocompatibility and tunable mechanical characteristics of GelMA provide its efficiency in the closure of wounds and tissue repair.GelMA hydrogels stand at the forefront of biomedical innovation, offering a versatile platform for addressing diverse challenges in drug delivery, tissue engineering, and wound healing. This review provides a comprehensive overview, fostering an in-depth understanding of GelMA hydrogel’s potential impact on progressing biomedical sciences.

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Section: Bone Tissue Engineeringmentioning

confidence: 86%

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Pramanik,

Alhomrani,

Alamri

et al. 2024

Biomed. Mater.

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“…Karkhaneh et al prepared the composite thiolated alginate (AlgT)/GelMA hydrogel loaded with MgO 2 polylactic acid- co -polyglycol (PLGA) microspheres. 105 After 21 days of co-culture of this hydrogel and BMSCs, the BMSCs showed osteogenic differentiation, including a significant expression of alkaline phosphatase, osteocalcin and osteopontin. Combining cell therapy and polymer microspheres can significantly enhance the therapeutic efficiency of bone defects in large animals.…”

Section: Classification Of Hydrogels For Bone Healingmentioning

confidence: 94%

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Zhang,

Qi,

Zhang

et al. 2024

Biomater. Sci.

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“…This technique effectively alleviates hypoxia in MC3T3‐E1 cells, which is crucial for promoting their osteogenic differentiation (12 mg L −1 , 24 h). Similarly, Nasrollah et al [ 200 ] designed a photo‐cross‐linked thiolated alginate (AlgT) system loaded with oxygen‐releasing PLGA@MgO 2 microspheres (7.7–8.2 mg L −1 , 14 days). The system also incorporates a gelatin acryloyl (GelMA) hydrogel to enhance oxygen and magnesium release, as well as pH regulation.…”

Section: Oxygen‐releasing Hydrogel For Tissue Repairmentioning

confidence: 99%

Oxygen‐Releasing Hydrogels for Tissue Regeneration

Jiang,

Zheng,

Xia

et al. 2024

Advanced NanoBiomed Research

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Hydrogels have emerged as a focal point of research in the biomedical field due to their applications in tissue repair. However, the majority of hydrogels lack the capability to release oxygen, constraining their therapeutic outcomes in environments with hypoxic tissues. In recent years, oxygen‐releasing hydrogels have garnered extensive attention in the field of tissue engineering, owing to their ability to modulate oxygen release and meet the diverse oxygenation requirements of various tissues. These hydrogels can enhance repair efficiency and promote tissue regeneration in hypoxic tissue environments. The design of oxygen‐releasing hydrogels primarily involves the utilization of diverse oxygen sources, such as algae, perfluorocarbons, and peroxides, to achieve optimal tissue oxygenation. This review provides a comprehensive summary of the design and fabrication strategies of oxygen‐releasing hydrogels, discusses deeply into their underlying oxygen‐releasing mechanisms, and their myriad applications in tissue repair along with the prospective challenges.

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Photo-click crosslinked hydrogel containing MgO2-loaded PLGA microsphere with concurrent magnesium and oxygen release for bone tissue engineering

Cited by 8 publications

References 59 publications

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects

Oxygen‐Releasing Hydrogels for Tissue Regeneration

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