Photo‐contact dermatitis from ketoprofen

Topical nonsteroidal antiinflammatory drugs: allergic and photoallergic contact dermatitis and phototoxicity

“…Phototoxic contact dermatitis from topical tiaprofenic acid and photoallergic contact dermatitis from topical ketoprofen, suprofen, and benzydamine have both been documented (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects

“…[1][2][3][4][5][6] Skin reactions in such cases have been reported to continue even weeks after the discontinuation of ketoprofen application to the skin. 3 One reason could be the presence of ketoprofen still in the skin, which has been shown in a skin biopsy specimen by chemical analysis.…”

Stimulation of Langerhans cells with ketoprofen plus UVA in murine photocontact dermatitis to ketoprofen

“…Second, there are differences among individuals in the susceptibility of LC responses to photohaptenic drugs upon UVA exposure. A number of reports have documented patients with severe photocontact dermatitis to KP [1,2,4]. In such cases, a predisposition to the photosensitivity might be closely associated with MHC haplotype.…”

“…While phototoxicity is mediated by active oxygen, especially singlet oxygen [8,9], photoallergy occurs as a consequence of a specific immune reaction mediated by antigenspecific, sensitized T cells [10][11][12][13][14]. KP has both phototoxic and photoallergic potentials, but many clinical observations have indicated that photosensitivity to KP is a photoallergic reaction [1][2][3][4][5][6][7].…”

“…Ketoprofen (KP), an arylpropionic acid derivative widely used as a topical anti-inflammatory drug, is clinically well known to induce photocontact dermatitis as an adverse reaction, and ultraviolet A (UVA) is the action spectrum of this photosensitivity [1][2][3][4][5][6][7]. In general, photoreactions by photosensitive chemicals are divided into the phototoxic and photoallergic types.…”