Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects

Hindsén, Monica; Isaksson, Marléne; Persson, Lena; Zimersson, Erik; Bruze, M.

doi:10.1016/j.jaad.2003.07.007

Cited by 52 publications

(27 citation statements)

References 9 publications

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“…Reactivation of dermatitis from contaminated sandals and bandages has been reported once before; at that time, the dermatitis was due to ketoprofen. 12 Finally, to further elucidate the sensitizing potential of MI as compared to MCI and the cross-reaction patterns, investigations that include a larger group of patients and in which there is knowledge of the specific sensitization (ie, patch-test sensitization or chemical burns) are needed. Animal studies such as GPMTs are also an option.…”

Section: Discussionmentioning

confidence: 99%

Occupational Contact Allergy and Dermatitis from Methylisothiazolinone after Contact with Wallcovering Glue and after a Chemical Burn from a Biocide

Isaksson¹,

Gruvberger²,

Bruze³

2004

Dermatitis

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Skin exposure to biocides containing high concentrations of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) may cause severe chemical burns and may also induce sensitization. We report two cases in which skin exposure to a newly launched biocide containing 2-methyl-4-isothiazolin-3-one (MI) and 1,2-benzisothiazolin-3-one led to sensitization to MI, which in the second case was preceded by a chemical burn. A study was performed to investigate the pattern of reactivity to MCI and MI in two patients who presumably had a primary sensitization to MI and in one patient who had been sensitized to MCI/MI by being patch-tested. The patients were patch-tested with serial dilutions of MCI/MI, MCI, MI, and 2-n-octyl-4-isothiazolin-3-one. The first two patients reacted to both MCI/MI and the separate active ingredients, with a higher level of reactivity to MI than to MCI. The third patient reacted to MCI/MI and MCI only. A biocide containing MI caused sensitization and occupational contact dermatitis in the first two patients, through contact with wallpaper glue in one case and after a chemical burn in the other case.

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Section: Discussionmentioning

confidence: 99%

Occupational Contact Allergy and Dermatitis from Methylisothiazolinone after Contact with Wallcovering Glue and after a Chemical Burn from a Biocide

Isaksson¹,

Gruvberger²,

Bruze³

2004

Dermatitis

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“…But localization and distribution of lesions may be more peculiar extending to areas of accidental contact, as in a contra-lateral limb (kissing faces of the legs) or areas of inadvertent spread by the hands or other contaminated objects [26]. Also, as some topical drugs are absorbed through the skin (NSAIDs), the distribution of the lesions can be similar to systemic photosensitivity.…”

Section: Clinical Patterns Of Photosensitivitymentioning

confidence: 99%

“…Reactions may recur on sun exposure with no apparent further drug application [34,91], but they do not fulfill the criteria for the diagnosis of persistent photosensitivity. Some may be explained by persistence of the drug in the skin (at least 17 days) [92] by contact with previously contaminated objects, even after washing [26], or from exposure to cross-reactive chemicals [34].…”

Section: Ketoprofenmentioning

confidence: 99%