Photo-crosslinked chitosan-gelatin xerogel-like coating onto “cold” plasma functionalized poly(lactic acid) film as cell culture support

Brebu, Mihai; Pamfil, Daniela; Stoica, Iuliana; Aflori, Magdalena; Voicu, Geanina; Stoleru, Elena

doi:10.1016/j.carbpol.2024.122288

Carbohydrate Polymers

2024

DOI: 10.1016/j.carbpol.2024.122288

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Photo-crosslinked chitosan-gelatin xerogel-like coating onto “cold” plasma functionalized poly(lactic acid) film as cell culture support

Mihai Brebu,

Daniela Pamfil,

Iuliana Stoica

et al.

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Cited by 1 publication

References 101 publications

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Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing

Yang,

Wu,

Yang

et al. 2024

Adv Healthcare Materials

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In the context of severe burn injuries, the presence of excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to the metabolic reprogramming of macrophages, resulting in a dysregulated inflammatory response that hinders the healing process. In this study, cerium oxide nanoparticles (CeNPs) are encapsulated within a silk fibroin‐poly(e‐caprolactone) polymer to create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This membrane is further modified through the addition of an angiopoietin‐1 mimetic peptide, QHREDGS, resulting in the formation of QPSF/CeNPs (QHREDGS modified PSF/CeNPs membrane). In vitro assessments revealed that the QPSF/CeNPs displayed the intended ability to regulate ROS levels, favorable biocompatibility with cells, promoted endothelial cell attachment and growth, exhibited anti‐inflammatory properties through the modulation of macrophage phenotypes from M1 to M2, as well as pro‐angiogenetic and antibacterial effects. In vivo, the membrane dressing demonstrated an acceleration of burn wound healing, promotion of angiogenesis, downregulation of inflammatory factors, and enhancement of collagen deposition. This bioactive membrane dressing shows potential as a clinical therapy for promoting the regeneration of both acute and chronically damaged skin tissue.

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Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing

Yang,

Wu,

Yang

et al. 2024

Adv Healthcare Materials

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show abstract

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Photo-crosslinked chitosan-gelatin xerogel-like coating onto “cold” plasma functionalized poly(lactic acid) film as cell culture support

Cited by 1 publication

References 101 publications

Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing

Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing

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