Photo-responsive intraocular lens with on demand drug release for posterior capsule opacification prevention and improved biosafety

Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement

“…As mentioned above, the severity of PCO can be graded according to the development of PCO: central posterior capsular opacification (CPCO, the 3 mm diameter pouch in the optical center), peripheral posterior capsular opacification (PPCO, the 6 mm diameter pouch in the optical region except the central part), Soemmering's ring (SR, the peripheral part of the capsule) and no PCO occurs [ 8 , [13] , [14] , [15] ]. The severity of PCO in each level was assessed on a scale of 0–3 points.…”

“…To evaluate the in vivo therapeutic efficacy of the Dox@Exos-modified IOLs, PCO models were constructed on two-month-old Japanese white rabbits by phacoemulsification combined with IOL implantation. The IOLs implantation and postoperative observation were by the methods of our previous publications [ 15 , 48 , 49 ]. The rabbits were treated, monitored, and evaluated according to the Association for Visual and Ophthalmic Research guidelines.…”

“…At present, in addition to the optimization of IOL shape and development of novel IOL materials, IOL surface modification, which is easy to prepare and does not require extra intraocular surgery also contributes to PCO prevention [ 6 , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. In previous studies, researchers mainly focused on hydrophilic coating on the IOL surface to prevent the adhesion of LECs [ [19] , [20] , [21] , [22] ].…”

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

“…The drug could be continuously released for four days in vitro and effectively promoted apoptosis. Subsequently, a light-controlled drug-releasing coating was used to carry 5-Fu ( Xia et al, 2022 ). This modification finely controlled drug release through illumination based on the photo reactivity of coumarin.…”

A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis

“…Previous studies focused on IOLs modification to prepare drug-loaded IOLs. Surface coating [ [11] , [12] , [13] , [14] , [15] , [16] , [17] ], chemical grafting [ [18] , [19] , [20] ], electrostatic interaction [ 21 ], and layer-by-layer self-assembly [ 22 , 23 ], which were all classified as surface modification techniques, have been studied. The ideas of creating extra drug-loading spaces on haptics were also reported [ 24 , 25 ].…”