Photoacoustic characterization of radiofrequency ablation lesions

Bouchard, Richard R.; Dana, Nicholas; Biase, Luigi Di; Emelianov, Stanislav

doi:10.1117/12.909161

Cited by 14 publications

(11 citation statements)

References 12 publications

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“…These local transients can be imaged using a traditional US transducer (20–22), providing an optical absorption map with resolutions on the order of tens of micrometers (or hundreds of micrometers using a 7.5 MHz US probe, which is common for EP intracardiac or transesophageal US applications and comparable to MRI) and at imaging depths in excess of a centimeter (18–22). …”

Section: Introductionmentioning

confidence: 99%

“…Due to the wavelength dependence of μ abs , spectroscopic photoacoustic imaging (sPA) can be performed for tissue characterization purposes (23–25). PA imaging's reliance upon ultrasonic sensing allows straightforward co-registration with anatomical US images, providing molecularly sensitive anatomical PA/US images (20–22). For these reasons, PA imaging is being pursued as a powerful medical imaging modality in cancer detection (26), disease staging (22) and therapy monitoring (21).…”

Section: Introductionmentioning

confidence: 99%

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In vitro photoacoustic visualization of myocardial ablation lesions

et al. 2014

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Background Radiofrequency (RF) ablation to treat atrial arrhythmia is limited by an inability to reliably assess lesion durability and transmurality. Objective Determine feasibility of photoacoustic characterization of myocardial ablation lesions in vitro. In this study, we investigate the feasibility of combined ultrasound (US) and spectroscopic photoacoustic (sPA) imaging to visualize RF ablation lesions in 3-D based on unique differences in the optical absorption spectra between normal and ablated myocardial tissue. Methods Tissue samples were excised from the ventricles of fresh porcine hearts. Lesions were generated using an RF catheter ablation system using 20 - 30 W of power applied for 40 - 60 s. Ablated samples were imaged in the NIR regime (740-780 nm) using a combined PA/US imaging system. Measured PA spectra were correlated to the absorption spectra of deoxy-hemoglobin and ablated tissue to produce a tissue characterization map (TCM) identifying 3-D lesion location and extent. Tissue samples were stained and photographed for gross pathology. TCM and gross pathology images were co-registered to assess TCM accuracy. Results The TCM reliably characterized ablated and non-ablated tissue up to depths of 3 mm. The TCM also assessed lesion position and extent with sub-millimeter accuracy in multiple dimensions. Segmented TCMs achieved greater than 69% agreement with gross pathology. Conclusion These results suggest that sPA imaging has the potential to accurately assess RF ablation lesion size and position with sub-millimeter precision and may be well suited to guide trans-catheter RF atrial ablation in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro photoacoustic visualization of myocardial ablation lesions

et al. 2014

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“…As examples, real-time OA imaging during radiofrequency (RF) ablation of ex vivo tissues has being shown 26 . Validation of the OA images of RF ablated tissues was further showcased 27 . Additionally, OA has been used to monitor ultrasound heating 28 , laser thermal treatments 21,29 or cryoablation 30 .…”

Section: Introductionmentioning

confidence: 99%

Tumor ablation and volumetric optoacoustic monitoring with a short-pulsed laser source

Periyasamy

Özsoy

Reiss

et al. 2019

Opto-Acoustic Methods and Applications in Biophotonics IV

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Laser ablation (LA) represents a minimally invasive intervention that is gaining acceptance for the treatment of different types of cancer, leading to important advantages such as less pain and shorter recovery time. Accurate monitoring of ablation progression is crucial to prevent damage of non-cancerous tissues and optimize the outcome of the intervention. To this end, imaging techniques such as ultrasound, computed tomography or magnetic resonance imaging have been used for monitoring LA. However, these techniques feature important drawbacks such as the need of contrast agents, poor spatio-temporal resolution or high cost. Optoacoustics (OA, photoacoustic) has recently been shown to provide unique properties to monitor thermal treatments. Herein, we demonstrate the feasibility of optoacoustic laser-ablation (OLA) monitoring in a murine breast tumor model using a single short-pulsed 1064 nm laser source. The effect of irradiation was volumetrically tracked with the OA images acquired with a 256-element spherical array. Structural damage of the tissue was clearly seen during the LA procedure.

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“…Photoacoustic imaging has multiple medical applications, with one focus being its potential to guide a variety of surgeries and procedures, including neurosurgeries [23], spinal fusion surgeries [24], hysterectomies [25]- [27], prostatectomies [28], fetal surgeries [29], abdominal surgeries [30], minimally invasive robotic surgeries [26], [31], and liver biopsies [32], [33]. In addition, photoacoustic imaging has been used to distinguish between ablated and healthy myocardial tissue after a radiofrequency ablation [34]- [36]. Bouchard et al [34] demonstrated 6-10 dB of contrast between ablated regions and normal tissue using a wavelength of 750 nm in ex vivo porcine cardiac tissue but with limited penetration depth.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Demonstration of Photoacoustic Image Guidance and Robotic Visual Servoing for Cardiac Catheter-Based Interventions

Graham

Assis

Allman

et al. 2020

IEEE Trans. Med. Imaging

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Cardiac interventional procedures are often performed under fluoroscopic guidance, exposing both the patient and operators to ionizing radiation. To reduce this risk of radiation exposure, we are exploring the use of photoacoustic imaging paired with robotic visual servoing for cardiac catheter visualization and surgical guidance. A cardiac catheterization procedure was performed on two in vivo swine after inserting an optical fiber into the cardiac catheter to produce photoacoustic signals from the tip of the fiber-catheter pair. A combination of photoacoustic imaging and robotic visual servoing was employed to visualize and maintain constant sight of the catheter tip in order to guide the catheter through the femoral or jugular vein, toward the heart. Fluoroscopy provided initial ground truth estimates for 1D validation of the catheter tip positions, and these estimates were refined using a 3D electromagnetic-based cardiac mapping system as the ground truth. The 1D and 3D root mean square errors ranged 0.25-2.28 mm and 1.24-1.54 mm, respectively. The catheter tip was additionally visualized at three locations within the heart: (1) inside the right atrium, (2) in contact with the right ventricular outflow tract, and (3) inside the right ventricle. Lasered regions of cardiac tissue were resected for histopathological analysis, which revealed no laser-related tissue damage, despite the use of 2.98 mJ per pulse at the fiber tip (379.2 mJ/cm 2 fluence). In addition, there was a 19 dB difference in photoacoustic signal contrast when visualizing the catheter tip

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Photoacoustic characterization of radiofrequency ablation lesions

Cited by 14 publications

References 12 publications

In vitro photoacoustic visualization of myocardial ablation lesions

In vitro photoacoustic visualization of myocardial ablation lesions

Tumor ablation and volumetric optoacoustic monitoring with a short-pulsed laser source

In Vivo Demonstration of Photoacoustic Image Guidance and Robotic Visual Servoing for Cardiac Catheter-Based Interventions

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