Photoacoustic imaging of human coronary atherosclerosis in two spectral bands

Jansen, Krista; Wu, Min; Steen, Antonius F.W. van der; Soest, Gijs van

doi:10.1016/j.pacs.2013.11.003

Cited by 133 publications

(106 citation statements)

References 25 publications

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“…Another limitation is that the PA imaging depth at 1.7 µm is lower than that at 1.2 µm [21]. Nevertheless, the imaging depth we achieved in our ex vivo measurements of human coronary arteries at 1.7 µm was about 3 mm, which is sufficient to image human coronary arteries [21,32]. The large absorption coefficient of superficial lipid did suppress the contrast of the deeper layer in the plaque shown in Fig.…”

Section: Discussionmentioning

confidence: 81%

“…Further noise reduction and increased transducer sensitivity will improve the accuracy and reliability of the lipid identification. Another limitation is that the PA imaging depth at 1.7 µm is lower than that at 1.2 µm [21]. Nevertheless, the imaging depth we achieved in our ex vivo measurements of human coronary arteries at 1.7 µm was about 3 mm, which is sufficient to image human coronary arteries [21,32].…”

Section: Discussionmentioning

confidence: 83%

“…The observation shows that reliable lipid detection requires multiple wavelengths. We have previously investigated the possibility of specific plaque lipid imaging using IVPA [13,21], and demonstrated that lipids in plaques can be differentiated from those in peri-adventitial fat using the correlation between the observed PA spectra data and the reference PA spectra data. This analysis requires at least 3 wavelengths in the 1.2 µm range.…”

Section: Introductionmentioning

confidence: 99%

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Specific imaging of atherosclerotic plaque lipids with two-wavelength intravascular photoacoustics

Jansen

Steen

et al. 2015

Biomed. Opt. Express

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Abstract:The lipid content in plaques is an important marker for identifying atherosclerotic lesions and disease states. Intravascular photoacoustic (IVPA) imaging can be used to visualize lipids in the artery. In this study, we further investigated lipid detection in the 1.7-µm spectral range. By exploiting the relative difference between the IVPA signal strengths at 1718 and 1734 nm, we could successfully detect and differentiate between the plaque lipids and peri-adventitial fat in human coronary arteries ex vivo. Our study demonstrates that IVPA imaging can positively identify atherosclerotic plaques using only two wavelengths, which could enable rapid data acquisition in vivo. References and links1. E. Falk, P. K. Shah, and V. Fuster, "Coronary Plaque Disruption," Circulation 92(3), 657-671 (1995 Caplan, A. P. Burke, R. Virmani, J. Goldstein, and J. E. Muller, "Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system," JACC Cardiovasc. Imaging 1(5), 638-648 (2008 93-110 (1985).

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Specific imaging of atherosclerotic plaque lipids with two-wavelength intravascular photoacoustics

Jansen

Steen

et al. 2015

Biomed. Opt. Express

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“…Photoacoustic (PA) imaging of lipid-rich plaques has been demonstrated under different wavelengths [14][15][16]. As reported, the 1.2 and 1.7 µm spectral bands resonant with the second and first overtone vibrations of the C-H bond and are suitable for IVPA imaging of lipid-rich plaques [17][18][19]. Compared with 1.2 µm excitation, 1.7 µm is more favorable for IVPA imaging due to the high absorption coefficient and less optical scattering by blood [18,20,21].…”

Section: Introductionmentioning

confidence: 91%

High-speed intravascular photoacoustic imaging at 17 μm with a KTP-based OPO

Hui

et al. 2015

Biomed. Opt. Express

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Lipid deposition inside the arterial wall is a hallmark of plaque vulnerability. Based on overtone absorption of C-H bonds, intravascular photoacoustic (IVPA) catheter is a promising technology for quantifying the amount of lipid and its spatial distribution inside the arterial wall. Thus far, the clinical translation of IVPA technology is limited by its slow imaging speed due to lack of a high-pulse-energy high-repetition-rate laser source for lipid-specific first overtone excitation at 1.7 μm. Here, we demonstrate a potassium titanyl phosphate (KTP)-based optical parametric oscillator with output pulse energy up to 2 mJ at a wavelength of 1724 nm and with a repetition rate of 500 Hz. Using this laser and a ring-shape transducer, IVPA imaging at speed of 1 frame per sec was demonstrated. Performance of the IVPA imaging system's resolution, sensitivity, and specificity were characterized by carbon fiber and a lipid-mimicking phantom. The clinical utility of this technology was further evaluated ex vivo in an excised atherosclerotic human femoral artery with comparison to histology. 503-505 (1994). 2. P. Libby, "Inflammation in atherosclerosis," Nature 420(6917), 868-874 (2002 385-390 (2014). 25. Y. Li, X. Gong, C. Liu, R. Lin, W. Hau, X. Bai, and L. Song, "High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter," J.

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“…TE-OCT may potentially be used for lipid-rich plaque detection, where lipid has stronger optical absorption at 1200 and 1700 nm than other tissues [42]. The short deformation accumulation time and the laser-based excitation make it possible to apply TE-OCT for endoscopic imaging at an A-line rate of 50-100 kHz, depending on the time required to capture the transient.…”

Section: MMmentioning

confidence: 99%