Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution

Jiang, Xuewu; Du, Bin; Tang, Shaoheng; Hsieh, Jer Tsong; Zheng, Jie

doi:10.1002/anie.201901525

Cited by 60 publications

(47 citation statements)

References 37 publications

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“…However, such gold nanoclusters exhibit always‐on PA signals and the signal difference relies on the different accumulation in the obstructed kidney due to decreased glomerular filtration rate (GFR). [ 28 ] Therefore, development of activatable PA probes for real‐time detection and diagnosis of kidney injury remains challenging.…”

Section: Figurementioning

confidence: 99%

Fluoro‐Photoacoustic Polymeric Renal Reporter for Real‐Time Dual Imaging of Acute Kidney Injury

et al. 2020

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Photoacoustic (PA) imaging agents detect disease tissues and biomarkers with increased penetration depth and enhanced spatial resolution relative to traditional optical imaging, and thus hold great promise for clinical applications. However, existing PA imaging agents often encounter the issues of slow body excretion and low‐signal specificity, which compromise their capability for in vivo detection. Herein, a fluoro‐photoacoustic polymeric renal reporter (FPRR) is synthesized for real‐time imaging of drug‐induced acute kidney injury (AKI). FPRR simultaneously turns on both near‐infrared fluorescence (NIRF) and PA signals in response to an AKI biomarker (γ‐glutamyl transferase) with high sensitivity and specificity. In association with its high renal clearance efficiency (78% at 24 h post‐injection), FPRR can detect cisplatin‐induced AKI at 24 h post‐drug treatment through both real‐time imaging and optical urinalysis, which is 48 h earlier than serum biomarker elevation and histological changes. More importantly, the deep‐tissue penetration capability of PA imaging results in a signal‐to‐background ratio that is 2.3‐fold higher than NIRF imaging. Thus, the study not only demonstrates the first activatable PA probe for real‐time sensitive imaging of kidney function at molecular level, but also highlights the polymeric probe structure with high renal clearance.

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Section: Figurementioning

confidence: 99%

Fluoro‐Photoacoustic Polymeric Renal Reporter for Real‐Time Dual Imaging of Acute Kidney Injury

et al. 2020

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“…GS-AuNP PA allows to take a clear image every second and, therefore, to visualize NPs transportation in real-time from the aorta to the renal parenchyma, their renal filtration, and their elimination. The data collected can then be used to quantify the GFR in healthy and unilateral ureteral obstruction (UUO) kidneys, demonstrating the possibility of applying this technology to detect the early stage of kidney injury [40].…”

Section: Optical Imagingmentioning

confidence: 99%

Nanotechnology, Nanomedicine, and the Kidney

et al. 2021

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The kidneys are vital organs performing several essential functions. Their primary function is the filtration of blood and the removal of metabolic waste products as well as fluid homeostasis. Renal filtration is the main pathway for drug removal, highlighting the importance of this organ to the growing field of nanomedicine. The kidneys (i) have a key role in the transport and clearance of nanoparticles (NPs), (ii) are exposed to potential NPs’ toxicity, and (iii) are the targets of diseases that nanomedicine can study, detect, and treat. In this review, we aim to summarize the latest research on kidney-nanoparticle interaction. We first give a brief overview of the kidney’s anatomy and renal filtration, describe how nanoparticle characteristics influence their renal clearance, and the approaches taken to image and treat the kidney, including drug delivery and tissue engineering. Finally, we discuss the future and some of the challenges faced by nanomedicine.

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“…Jiang et al in 2019 reported the strong NIR absorption of Au 25 (SG) 18 nanoclusters and successfully used these for photoacoustic (PA) imaging to in situ visualize their transport through the aorta to the renal parenchyma and subsequent filtration into the renal pelvis at a temporal resolution down to 1 s. [ 101 ] Ultrasmall gold nanoclusters (Au NCs) with a particle size of ~1 nm are emerging as promising nanoparticles due to their structure, unique physicochemical properties, facile surface functionalization, and good biocompatibility [ 102 ] ; they have many unique advantages and exhibit great potential in biomedical research. [ 103 ]…”

Section: Applicationmentioning

confidence: 99%

Natural source of carbon dots from part of a plant and its applications: a review

et al. 2021

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Carbon dots (CDs) are carbon nanoparticles with a size of less than 10 nm, and are synthesized from various sources; they have been of great interest to scientists worldwide due to their unique optical, electrical, and chemical properties. Sources of carbon are inexpensive and can be classified as a renewable natural resources. Many researchers use CDs because of their low toxicity, better water solubility, high biocompatibility, and stable photoluminescence. The simple methods for producing CDs are hydrothermal and use inexpensive equipment, have low energy consumption, simple manipulation, and one‐step preparation. Since the discovery of CDs, researchers have used them in various applications such as sensing, bioimaging, drug delivery, and catalysis. In this review, CDs synthesized from natural resources such as samples from herbs, roots, leaves, flowers, and fruit and some applications are described. This review provides a summary of carbon dots that is expected to provide further information for development of new CDs.

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Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution

Cited by 60 publications

References 37 publications

Fluoro‐Photoacoustic Polymeric Renal Reporter for Real‐Time Dual Imaging of Acute Kidney Injury

Fluoro‐Photoacoustic Polymeric Renal Reporter for Real‐Time Dual Imaging of Acute Kidney Injury

Nanotechnology, Nanomedicine, and the Kidney

Natural source of carbon dots from part of a plant and its applications: a review

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