Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye‐Labeled Cargo

Jeevarathinam, Ananthakrishnan Soundaram; Lemaster, Jeanne E.; Chen, Fang; Zhao, Eric; Jokerst, Jesse V.

doi:10.1002/anie.201914120

Cited by 72 publications

(60 citation statements)

References 38 publications

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“…The reduction of methylene blue is a reversible and environment-dependent process, especially in oxygen-rich aqueous environments [40,41], which this system was. However, in semiconductor sensitized systems, the reduction of MB to its leuco form (LMB) is irreversible [42].…”

Section: The Effect Of the Amount Of The Photocatalystsmentioning

confidence: 90%

SnO2-Containing Clinoptilolite as a Composite Photocatalyst for Dyes Removal from Wastewater under Solar Light

et al. 2020

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Due to their adsorbent, ion exchange and catalytic properties zeolites are suitable for a variety of applications. We report on the photocatalytic activity of a readily available and inexpensive natural zeolite clinoptilolite (Z) containing SnO2 (Sn-Z). The Sn-Z samples with 3–15 wt. % of Sn were prepared by using a precipitation–deposition method. Powder X-ray diffraction analysis showed that the zeolite structure was unaffected by the introduction of the Sn-phase. Diffuse reflectance UV/VIS spectra of the Sn-Z samples confirmed the presence of SnO2 and X-Ray absorption spectroscopy analyses suggested that the SnO2 particles mainly resided on the surface of the clinoptilolite, while ATR-FTIR analysis gave some clues that part of the SnO2 phase was incorporated in the pores of the zeolite. The presence of SnO2 in Sn-Z increased both adsorption capacity and photocatalytic performance which could be partially explained by higher surface area and partially with an increased negative potential of the surface. Adsorption and total degradation of methylene blue (MB) for the Sn-Z with the highest amount of Sn (15 wt.%) was about 30% and 45%, respectively, suggesting a synergetic effect between SnO2 and the clinoptilolite lattice. Reusability tests showed that these catalysts present a promising material for water purification.

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Section: The Effect Of the Amount Of The Photocatalystsmentioning

confidence: 90%

SnO2-Containing Clinoptilolite as a Composite Photocatalyst for Dyes Removal from Wastewater under Solar Light

et al. 2020

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“…Wang et al had demonstrated a 492-folds increase in PA signal with MB encapsulated in sodium dodecyl sulfate (SDS) micelles [ 61 ]. Recently, Jeevarathinam et al utilized the redox chemistry of MB to photoacoustically quantify drug release from nanocarriers [ 62 ]. Paclitaxel conjugated to a chemically reduced form, leuco form methylene blue (LMB), which was encapsulated in a poly(lactic-co-glycolic acid) NP.…”

Section: Exogenous Contrast Agentsmentioning

confidence: 99%

“…Upon the release of paclitaxel, the PA silent LMB will be spontaneously oxidized into PA active MB. By monitoring the increase in PA signals generated by the MB, the amount of paclitaxel release can be quantified [ 62 ]. Nonetheless, most of these MPACs, like cyanine dyes, are susceptible to photoisomerization, photobleaching ( Figure 8 ), and solvatochromism.…”

Section: Exogenous Contrast Agentsmentioning

confidence: 99%

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Tsang

Wong

2020

Sensors

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Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

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“…Future investigations may explore the potential benefit or harm of using isoniazid in the chemical composition of the present MNP formulation in vitro and in vivo. Furthermore, our research group will consider conducting studies to explore more directions related to the use of MNPs, such as the role of MNPs as acoustic imaging tools [51].…”

Section: In Vivo Oral Pharmacokinetic Studiesmentioning

confidence: 99%

Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles

et al. 2020

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The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N′-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic nanoparticles (CFT-MIH-MNPs). Atomic force microscopy (AFM) and dynamic light scattering (DLS) showed that the developed CFT loaded MIH-MNPs are spherical, with a measured hydrodynamic size of 184.0 ± 2.7 nm and negative zeta potential values (–20.2 ± 0.4 mV). Fourier transformed infrared spectroscopic (FTIR) analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiency (EE) of 79.4% ±1.5%, and the drug was released gradually in vitro and showed prolonged in vitro stability using simulated gastrointestinal tract (GIT) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.4 ± 1.8 µg/mL in comparison with its control (2.0 ± 0.6 µg/mL). Overall, the developed CFT-MIH-MNPs formulation was promising for provision of high drug entrapment, gradual drug release and suitability for enhancing the oral delivery of CFT.

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Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye‐Labeled Cargo

Cited by 72 publications

References 38 publications

SnO2-Containing Clinoptilolite as a Composite Photocatalyst for Dyes Removal from Wastewater under Solar Light

SnO2-Containing Clinoptilolite as a Composite Photocatalyst for Dyes Removal from Wastewater under Solar Light

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles

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