Photoacoustic imaging with low-cost sources; A review

Erfanzadeh, Mohsen; Zhu, Quing

doi:10.1016/j.pacs.2019.01.004

Cited by 99 publications

(74 citation statements)

References 75 publications

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“…PA imaging has become increasingly popular due to its deep signal penetration (ࣘ5-6 cm), high resolution (ࣙ5 µm), and decreasing instrument costs. [12][13][14][15][16] Furthermore, because the molecular contrast agents for PA imaging are optimized for non-radiative emission, many of these same materials can be utilized for PTT, allowing dual clinical functionality. [9] PTT has a potential advantage over photodynamic therapy, in that it does not require the presence of oxygen, the concentration of which may be limited in large solid tumors.…”

Section: Introductionmentioning

confidence: 99%

“…NIR photomedicine has been broadly applied in cancer treatment and imaging through numerous modalities, including photodynamic therapy, or PDT (light excites a photoactive agent to a triplet excited state, which then directly or indirectly generates free radicals and/or reactive oxygen species); photothermal therapy, or PTT (absorbed energy is emitted as vibrational energy, i.e., heat); fluorescence imaging (energy is emitted radiatively as a photon); and photoacoustic imaging, or PA (energy is emitted as heat, which generates a detectable acoustic wave). PA imaging has become increasingly popular due to its deep signal penetration (≤5–6 cm), high resolution (≥5 µm), and decreasing instrument costs . Furthermore, because the molecular contrast agents for PA imaging are optimized for non‐radiative emission, many of these same materials can be utilized for PTT, allowing dual clinical functionality .…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine Green–Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy

Dempsey

Amirshaghaghi

Case

et al. 2019

Advanced Therapeutics

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Traditional oncology treatment modalities are often associated with a poor therapeutic index. This has driven the development of new targeted treatment modalities, including several based on the conversion of optical light into heat energy (photothermal therapy, PTT) and sound waves (photoacoustic imaging, PA) that can be applied locally. These approaches are especially effective when combined with photoactive nanoparticles that preferentially accumulate in tissues of interest and thereby further increase spatiotemporal resolution. In this study, two clinically used materials that have proven effective in both PTT and PA-indocyanine green (ICG) and gold nanoparticles (AuNPs)-are combined into a single nanoformulation. These particles, "ICG-AuNP clusters," incorporate high concentrations of both moieties without the need for additional stabilizing or solubilizing reagents. The clusters demonstrate high theranostic efficacy both in vitro and in vivo, compared with ICG alone. Specifically, in an orthotopic mouse model of triple-negative breast cancer, ICG-AuNP clusters can be injected intravenously, imaged in the tumor by PA, and then combined with near-infrared laser irradiation to successfully thermally ablate tumors and prolong animal survival. Altogether, this novel nanomaterial demonstrates excellent therapeutic potential for integrated treatment and imaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Indocyanine Green–Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy

Dempsey

Amirshaghaghi

Case

et al. 2019

Advanced Therapeutics

View full text Add to dashboard Cite

show abstract

“…PAI is a high contrast, non-invasive and non-ionizing imaging modality with extensive applications in anatomical and functional imaging that has been used for diagnostics purposes and cancer studies [59,99,[113], [114], [115], [116], [117], [118]]. Cost is one major factor hindering PACT’s implementation in clinical field.…”

Section: Discussionmentioning

confidence: 99%

Review of cost reduction methods in photoacoustic computed tomography

et al. 2019

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Photoacoustic Computed Tomography (PACT) is a major configuration of photoacoustic imaging, a hybrid noninvasive modality for both functional and molecular imaging. PACT has rapidly gained importance in the field of biomedical imaging due to superior performance as compared to conventional optical imaging counterparts. However, the overall cost of developing a PACT system is one of the challenges towards clinical translation of this novel technique. The cost of a typical commercial PACT system originates from optical source, ultrasound detector, and data acquisition unit. With growing applications of photoacoustic imaging, there is a tremendous demand towards reducing its cost. In this review article, we have discussed various approaches to reduce the overall cost of a PACT system, and provided a cost estimation to build a low-cost PACT system.

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“…However, these lasers are also bulky, expensive, and delicate. Thus, recent efforts have focused on low-cost light sources such as pulsed laser diodes (PLDs) and light-emitting diodes (LEDs) to further facilitate widespread clinical utility of PAI [15,16]. LED-based PAI imaging equipment is relatively inexpensive, compact, portable, and lightweight; these LEDs have a long life-time and good stability [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Dictionary learning technique enhances signal in LED-based photoacoustic imaging

Farnia

Najafzadeh

Hariri

et al. 2020

Biomed. Opt. Express

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There has been growing interest in low-cost light sources such as light-emitting diodes (LEDs) as an excitation source in photoacoustic imaging. However, LED-based photoacoustic imaging is limited by low signal due to low energy per pulse-the signal is easily buried in noise leading to low quality images. Here, we describe a signal de-noising approach for LED-based photoacoustic signals based on dictionary learning with an alternating direction method of multipliers. This signal enhancement method is then followed by a simple reconstruction approach delay and sum. This approach leads to sparse representation of the main components of the signal. The main improvements of this approach are a 38% higher contrast ratio and a 43% higher axial resolution versus the averaging method but with only 4% of the frames and consequently 49.5% less computational time. This makes it an appropriate option for real-time LED-based photoacoustic imaging.

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Photoacoustic imaging with low-cost sources; A review

Cited by 99 publications

References 75 publications

Indocyanine Green–Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy

Indocyanine Green–Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy

Review of cost reduction methods in photoacoustic computed tomography

Dictionary learning technique enhances signal in LED-based photoacoustic imaging

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