Photoacoustic Mouse Brain Imaging Using an Optical Fabry-Pérot Interferometric Ultrasound Sensor

Chen, Yu‐Wen; Chen, Buhua; Yu, Ting; Yin, Lu; Sun, Mingjian; He, Wen; Ma, Cheng

doi:10.3389/fnins.2021.672788

Cited by 9 publications

(11 citation statements)

References 38 publications

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“…Optical ultrasound sensors have been explored to overcome the limited bandwidth and acceptance angle of the piezoelectric ultrasound sensors [18][19][20][21][22]. A variety of optical ultrasound sensors with promising performance have been developed for a number of PACT applications, including high-finesse planar sensor [23], in-fiber Fabry-Pérot interferometer [19,24], in-fiber laser sensor [25,26], submicrometer sensors on a photonic chip [27,28], and optomechanical ultrasound sensors [29]. In these optical ultrasound sensors, the PA signals are detected by measuring pressure-induced optical phase change over the optical path.…”

Section: Introductionmentioning

confidence: 99%

“…As shown in Figures2(b) and 2(c), the FWHM of the LSF was measured as the spatial resolution along each axis. The lateral resolution, which was mainly determined by the central frequency and the effective detection aperture, was measured to be ~114 μm[24]. The axial resolution, which was majorly determined by the bandwidth of the MRR sensor, was measured to be ~57 μm.…”

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confidence: 99%

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High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

et al. 2022

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3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth, and high sensitivity. In this work, we present a new high-frequency 3D-PACT system that uses a microring resonator (MRR) as the acoustic sensor. The MRR sensor has a size of 80 μm in diameter and was fabricated using the nanoimprint lithography technology. Using the MRR sensor, we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of ~23 MHz, an imaging depth of ~8 mm, a lateral resolution of 114 μm, and an axial resolution of 57 μm. We have demonstrated the 3D PACT’s performance on in vitro phantoms, ex vivo mouse brain, and in vivo mouse ear and tadpole. The MRR-based 3D-PACT system can be a promising tool for structural, functional, and molecular imaging of biological tissues at depths.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

et al. 2022

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“…Once the optical source has been chosen, the light needs to be guided toward the target material. Light is typically delivered through optical fibers, and the coupling with the light source could be achieved using a coupler [ 62 , 116 , 124 , 160 ] (e.g., F810SMA-543 and DC1300LEFA from Thorlabs), a collimator [ 7 , 30 , 60 , 74 , 161 ] or both a collimator and convex lens [ 128 ].…”

Section: Characterizationmentioning

confidence: 99%

A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications

Barbosa

Mendes

2022

Sensors

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The photoacoustic effect is an emerging technology that has sparked significant interest in the research field since an acoustic wave can be produced simply by the incidence of light on a material or tissue. This phenomenon has been extensively investigated, not only to perform photoacoustic imaging but also to develop highly miniaturized ultrasound probes that can provide biologically meaningful information. Therefore, this review aims to outline the materials and their fabrication process that can be employed as photoacoustic targets, both biological and non-biological, and report the main components’ features to achieve a certain performance. When designing a device, it is of utmost importance to model it at an early stage for a deeper understanding and to ease the optimization process. As such, throughout this article, the different methods already implemented to model the photoacoustic effect are introduced, as well as the advantages and drawbacks inherent in each approach. However, some remaining challenges are still faced when developing such a system regarding its fabrication, modeling, and characterization, which are also discussed.

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“…PA imaging has also been used to detect neurological disorders like stroke, tumour, and Alzheimer's. It was validated by Chen et al (2021) using the Fabry Perot Interferometry (FPI) mesoscope for cerebrovascular mouse brain imaging using a photothermally tuneable FPI ultrasound sensor.…”

Section: Application Domainmentioning

confidence: 99%

A Review of Optical Ultrasound Imaging Modalities for Intravascular Imaging

Rushambwa¹,

Suvendi²,

Pandelani³

et al. 2022

JST

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Recent advances in medical imaging include integrating photoacoustic and optoacoustic techniques with conventional imaging modalities. The developments in the latter have led to the use of optics combined with the conventional ultrasound technique for imaging intravascular tissues and applied to different areas of the human body. Conventional ultrasound is a skin contact-based method used for imaging. It does not expose patients to harmful radiation compared to other techniques such as Computerised Tomography (CT) and Magnetic Resonance Imaging (MRI) scans. On the other hand, optical Ultrasound (OpUS) provides a new way of viewing internal organs of the human body by using skin and an eye-safe laser range. OpUS is mostly used for binary measurements since they do not require to be resolved at a much higher resolution but can be used to check for intravascular imaging. Various signal processing techniques and reconstruction methodologies exist for Photo-Acoustic Imaging, and their applicability in bioimaging is explored in this paper.

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Photoacoustic Mouse Brain Imaging Using an Optical Fabry-Pérot Interferometric Ultrasound Sensor

Cited by 9 publications

References 38 publications

High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator

A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications

A Review of Optical Ultrasound Imaging Modalities for Intravascular Imaging

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