Photoactivated disinfection (PAD) of dental root canal system – An ex-vivo study

Mohan, Dennis; Maruthingal, Sunith; Indira, R; Divakar, Darshan Devang; Kheraif, Abdulaziz A. Al; Ramakrishnaiah, Ravikumar; Durgesh, B. H.; Basavarajappa, Santhosh

doi:10.1016/j.sjbs.2015.01.013

Cited by 21 publications

(18 citation statements)

References 16 publications

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“…No adverse clinical signs and symptoms were noted during follow up periods, which is considered as a primary goal for regenerative endodontics as reported by AAE 13 . Apical closure and increasing apical dentin thickness were observed at the 12-month follow-up period.…”

Section: Discussionmentioning

confidence: 69%

“…Copious and gentle irrigation was done using 20ml NaOCl. The use of NaOCl at lower concentrations was advised (1.5% NaOCl) with the irrigating needle adjusted to be 1mm from the root end to reduce the cytotoxicity to stem cells and to minimize the possibility of irrigant extrusion into the periapical tissues 13 . Furthermore, 1.5% NaOCl was effective in bacterial reduction of root canals as reported by Trevino et al 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Inducing bleeding to promote blood clot formation is a commonly used method in many of the reported cases 17-20 . A resorbable matrix (collagen wound dressing) should be carefully placed on the top of the blood clot to serve as an internal matrix and ease the placement of MTA 13 . White MTA was applied to act as a coronal plug and achieve effective coronal seal.…”

Section: Discussionmentioning

confidence: 99%

“…The case was managed by single visit regenerative endodontic procedure using PAD after obtaining written informed consent from the parents (including usage of data and publication) and assent from the child. The procedure was performed according to the American Association of Endodontics (AAE) guidelines 13 , except PAD instead of TAP was used. A 1.8ml carpule of mepivacaine 3% (Mepivacaine hydrochloride, Alexandria Co. for Pharmaceuticals, Egypt) was administered by infiltration.…”

Section: Case Reportmentioning

confidence: 99%

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Case Report: Photo-activated oral disinfection in regenerative endodontics

et al. 2019

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Background: Root canal disinfection is considered critical for achieving successful regenerative endodontic procedures. Photo-activated oral disinfection is a novel disinfection method that can help to achieve the goal of regenerative endodontics. This article reports the clinical and radiographic results after single visit regenerative endodontics using photo-activated oral disinfection. Methods: An 8.5-year-old girl complained of fractured upper right central incisor. Pulp necrosis was diagnosed on the basis of clinical findings. The root canal was irrigated with sodium hypochlorite solution (1.5%) followed by saline. Then, the canal was dried with paper points. A combination of a photosensitizer solution and low power laser light were applied. EDTA solution was used as a final irrigant. Bleeding was induced, followed by placement of collagen resorbable matrix and white mineral trioxide aggregate. Two days later, the tooth was sealed and restored with permanent filling. Results: Clinical findings revealed no pain on percussion or palpation tests. Radiographic examination revealed an increase in root length, an increase of apical root thickness and apical closure at the 12-month follow-up period. Conclusion: Regenerative endodontics using photo-activated oral disinfection achieved successful outcomes in the necrotic immature permanent tooth.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Case Report: Photo-activated oral disinfection in regenerative endodontics

et al. 2019

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“…[29,30]. This relative low concentration does not cause any tissue irritation and dentinal discoloration [31]. Photosensitizing liquid contains salts for optimum tonicity, buffers to ensure reliable aPDT effectiveness in different situations, preservatives, antioxidants and surfactants which has surface wetting effects [32].…”

Section: Photosensitizing Dyesmentioning

confidence: 99%

Anti-microbial Photo Dynamic Therapy (aPDT) in Endodontics: A Literature Review

Ahmad¹

2018

IJDSR

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Elimination of root canal pathogens is one of the main objectives for successful outcome of root canal treatment. Conventional chemo-mechanical debridement is not always successful in removing all bacteria. Adjunctive use of antimicrobial photodynamic therapy (aPDT) can be a used as a practical approach for successful elimination of all these bacteria. The aim of this review was to assess scientific literature that used various photosensitizers for bacterial reduction using aPDT methods. A search of the PubMed and Cochrane data bases using appropriate terms and keywords related to antimicrobial photodynamic therapy in endodontic disinfection was conducted. A hand search also was conducted in the preceding 5 years of several journals. Full texts of the selected articles were obtained and analyzed. A total of 177 articles published were identified at first stage of data extraction. After final screening, 41 articles were included in this review. This review summarizes the usage principles of aPDT and outlines the applications of aPDT in root canal disinfection procedures. It was concluded that aPDT should be used in conjunction with the conventional chemo mechanical debridement and disinfection of root canal system. It is critical to note that selection of photosensitizer dye, its correct delivery within the prepared root canal system, laser application with correct type of tips are predictors for successful outcome of this protocol of root canal disinfection.

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Evaluation of effectiveness of photosensitizers used in laser endodontics disinfection: A systematic review

Sin

Walsh

Figueredo

et al. 2020

Transl Biophotonics

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Photo-activated disinfection using photosensitizers has been proposed as an adjunct to conventional endodontic therapy for additional disinfection and improved treatment outcomes. This systematic review aims to investigate the effectiveness of photosensitizers used in laser endodontics disinfection. A comprehensive literature search is conducted to identify in vitro and in vivo studies involving photo-activated disinfection in endodontic treatment. Publications are selected based on predetermined eligibility criteria. From 121 articles, 34 met the inclusion criteria, comprising eight polymicrobial and 26 bacteria-specific studies. A total of 10 photosensitizers were investigated, including methylene blue, tolonium chloride, polyethylenimine and chlorin (e6), phenothia zinium, chitosan, rose bengal, malachite green, indocyanine green, chlorine p6 and curcumin. Photo-activated disinfection using tolonium chloride or methylene blue can be an effective adjunct to conventional root canal therapy. More studies are needed to assess the performance of newer photosensitizers to optimize photoactivated disinfection of the complex root canal space.

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Photoactivated disinfection (PAD) of dental root canal system – An ex-vivo study

Abstract: PAD may be an adjunctive procedure to kill residual bacteria in the dental root canal systems after standard endodontic root canal preparation.

Cited by 21 publications

References 16 publications

Case Report: Photo-activated oral disinfection in regenerative endodontics

Case Report: Photo-activated oral disinfection in regenerative endodontics

Anti-microbial Photo Dynamic Therapy (aPDT) in Endodontics: A Literature Review

Evaluation of effectiveness of photosensitizers used in laser endodontics disinfection: A systematic review

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