Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy

Abstract

Nanohybrids have gained immense popularity for the diagnosis and chemotherapy of lung cancer for their excellent biocompatibility, biodegradability, and targeting ability. However, most of them suffer from limited imaging information, low tumor-to-background ratios, and multidrug resistance, limiting their potential clinical application. Herein, we engineered a photoresponsive nanohybrid by assembling polypyrrole@bovine serum albumin (PPy@BSA) encapsulating perfluoropentane (PFP)/129Xe for selective magnetic resonance (MR)/ultrasonic (US)/photoacoustic (PA) trimodal imaging and photothermal therapy of lung cancer, overcoming these drawbacks of single imaging modality and chemotherapy. The nanohybrid exhibited superior US, PA, and MR multimodal imaging performance for lung cancer detection. The high sensitivity of the nanohybrid to near-infrared light (NIR) resulted in a rapid increase in temperature in a low-intensity laser state, which initiated the phase transition of liquid PFP into the gas. The ultrasound signal inside the tumor, which is almost zero initially, is dramatically increased. Beyond this, it led to the complete depression of 19F/129Xe Hyper-CEST (chemical exchange saturation transfer) MRI during laser irradiation, which can precisely locate lung cancer. In vitro and in vivo results of the nanohybrid exhibited a successful therapeutic effect on lung cancer. Under the guidance of imaging results, a sound effect of photothermal therapy (PTT) for lung cancer was achieved. We expect this nanohybrid and photosensitive behavior will be helpful as fundamental tools to decipher lung cancer in an earlier stage through trimodality imaging methods.

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

“…For optoacoustic tomography (OAT) and MRI-guided PTT in orthotopic hepatocellular carcinoma, the epithelial cell adhesion molecule (EpCAM)-conjugated PEGylated Fe 3 O 4 @AuNPs were demonstrated . The perfluoropentane (PFP)-loaded nanohybrid with polypyrrole (PPy) and bovine serum albumin (BSA) shells was developed for MRI/ultrasonic imaging/PAI . In this system, PPy acts as a photothermal agent, while BSA renders biocompatibility, PFP is needed for ultrasonic imaging, and 19 F/ 129 Xe is needed for Hyper-CEST (chemical exchange saturation transfer) MRI.…”

“…98 The perfluoropentane (PFP)loaded nanohybrid with polypyrrole (PPy) and bovine serum albumin (BSA) shells was developed for MRI/ultrasonic imaging/PAI. 99 In this system, PPy acts as a photothermal agent, while BSA renders biocompatibility, PFP is needed for ultrasonic imaging, and 19 F/ 129 Xe is needed for Hyper-CEST (chemical exchange saturation transfer) MRI. Lee et al prepared MnCO 3 -mineralized fluorescent PDA nanoparticles for dual fluorescence/MRI-guided PTT, which can be triggered by acidic pH.…”

Monitoring ROS Responsive Fe3O4‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via 129Xe MRI

“…[16] In contrast, MRI has the advantage of non-ionizing radiation, along with high spatial resolution and good soft tissue contrast, making it widely used in clinical disease detection. [17] The mainstream MRI is based on imaging using water protons, but the lung is a cavity structure with low water proton density, severely limiting the monitoring capabilities of 1 H MRI in the process of lung cancer immunotherapy. Fortunately, the emerging technology of hyperpolarized 129 Xe MRI, with its ultra-high sensitivity, is particularly suitable for detecting lung diseases [18] and has played a crucial role in assessing lung function in COVID-19 patients.…”