Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment

Zmejkoski, Danica; Marković, Zoran M.; Budimir, Milica; Zdravković, Nemanja; Trišić, Dijana; Bugárová, Nikola; Danko, Martin; Kozyrovska, Natalia; Špitalský, Zdeno; Kleinová, Angela; Kuzman, Sanja; Pavlović, Vladimir B.; Marković, Biljana M. Todorović

doi:10.1016/j.msec.2021.111925

Cited by 32 publications

(23 citation statements)

References 44 publications

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“…The positions, full width at half maximum (FWHM) and degree of crystallinity of all tested samples are listed in Table S4. The three distinct diffraction peaks at 14.22°, 16.74°, and 22.48° which correspond to the crystal planes (1–10), (200), and (110) are observed in the XRD pattern of BC 22 . The peaks at 10.00°, 19.76°, and 43.00° which correspond to the crystal planes (001), (002), and (100) can be seen in the XRD pattern of GQDs 23 .…”

Section: Resultsmentioning

confidence: 99%

“…The GQDs‐BC composite hydrogels samples were prepared by the following: BC composite hydrogels (6 cm in diameter) were dipped into GQDs acetone suspension (0.2 and 2 mg/ml) for 2 days at room temperature (obtained composites were labeled as GQDs‐BC0.2 and GQDs‐BC2, respectively) 22 . Then samples were dried in vacuum oven at 60°C overnight.…”

Section: Experimental Methodsmentioning

confidence: 99%

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Photoactive graphene quantum dots/bacterial cellulose hydrogels: Structural, mechanical, and pro‐oxidant study

Marković

Zmejkoski

Budimir

et al. 2021

J of Applied Polymer Sci

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Due to their unique structural properties bacterial cellulose (BC) hydrogels find possible usage in many fields such as cosmetology, food industry, or medicine. In this study, photoactive BC hydrogels are investigated through modifications of their structural, mechanical, and pro‐oxidant properties resulting from graphene quantum dots (GQDs) encapsulation. Detailed structural analysis is conducted by atomic force microscopy, transmission electron microscopy and scanning electron microscopy, X‐ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and X‐ray diffraction method. Dynamic mechanical analysis is performed to study the changes in storage modulus, loss modulus and tan δ. Pro‐oxidative properties of new designed composites are tested by electron paramagnetic resonance (EPR). Structural and mechanical analyses show successful encapsulation of GQDs into BC whereas EPR measurements indicate high potential of these composites for singlet oxygen production.

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Section: Resultsmentioning

confidence: 99%

Section: Experimental Methodsmentioning

confidence: 99%

Photoactive graphene quantum dots/bacterial cellulose hydrogels: Structural, mechanical, and pro‐oxidant study

Marković

Zmejkoski

Budimir

et al. 2021

J of Applied Polymer Sci

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“…Scratch assay 13 was used to assess the migratory ability of endothelial cells. HUVECs were seeded in a six‐well plate.…”

Section: Methodsmentioning

confidence: 99%

Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization

Ding

Liu

et al. 2021

Immunity Inflam & Disease

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Titanium has been widely used in prosthetic valves, but they are associated with serious defects in titanium‐based prosthetic valves, such as thrombosis, calcification, and decay. Therefore, it is very important to biofunctionalize titanium‐based valves to reduce inflammation and accelerate endothelialization of stents and antithrombosis. The titanium dioxide nanotubes were prepared from pure titanium (Ti) by anodic oxidation method in this study. The effects of titanium dioxide nanotubes on the metabolism of macrophages and the inflammatory reaction as implants were studied in vitro. The polarization state of macrophages and the ability to accelerate endothelialization were analyzed. The results demonstrated that titanium nanotubes promote M2 polarization of macrophages by inhibiting glycolysis and activating the Adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway. In general, biofunctionalization titanium with nanotube could inhibit macrophage glycolysis, reduce inflammatory factor release and promote M2 polarization by activating the AMPK signaling pathway. And endothelialization was accelerated in vitro. Our result demonstrated that titanium nanotube could act as a potential approach to biofunctionlize titanium‐based prosthetic valves for endothelialization.

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“…Nano-CS obtained by gamma irradiation, which is covered by bacterial cellulose, could significantly inhibit microbial strains in difficult-to-heal oral wounds [ 23 ]. This antimicrobial activity can inhibit bacterial invasion to protect the wound from secondary infection [ 23 ]. Nano-CS has a disc-like shape and an average diameter in the range of 40 to 60 nm.…”

Section: Application Of Nano-cs As Drug Carriers In Oral Soft Tissue Diseasesmentioning

confidence: 99%

“…Nano-CS has a disc-like shape and an average diameter in the range of 40 to 60 nm. However, the release of nano-CS from BC is slow and continuous [ 23 ]. Tee [ 11 ] formed nano-CS loaded with recombinant human keratinocyte growth factor (nano-CS/rHuKGF) to increase the stability of rHuKGF and prevent rHuKGF proteolysis in saliva.…”

Section: Application Of Nano-cs As Drug Carriers In Oral Soft Tissue Diseasesmentioning

confidence: 99%

The Application of Chitosan Nanostructures in Stomatology

2021

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Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, and their biodegradability. Nano-CSs can be applied as drug carriers for soft tissue diseases, bone tissue engineering and dental hard tissue remineralization; furthermore, they have been used in endodontics due to their antibacterial properties; and, finally, nano-CS can improve the adhesion and mechanical properties of dental-restorative materials due to their physical blend and chemical combinations. In this review, recent developments in the application of nano-CS for stomatology are summarized, with an emphasis on nano-CS’s performance characteristics in different application fields. Moreover, the challenges posed by and the future trends in its application are assessed.

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Photoactive and antioxidant nanochitosan dots/biocellulose hydrogels for wound healing treatment

Cited by 32 publications

References 44 publications

Photoactive graphene quantum dots/bacterial cellulose hydrogels: Structural, mechanical, and pro‐oxidant study

Photoactive graphene quantum dots/bacterial cellulose hydrogels: Structural, mechanical, and pro‐oxidant study

Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization

The Application of Chitosan Nanostructures in Stomatology

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