Photoallergic contact dermatitis due to diclofenac with cross‐reaction to aceclofenac: two case reports

Fernández-Jorge, Beatriz; Goday-Buján, J.; Murga, Manuel Mejía; Molina, Francisca; Pérez-Varela, L.; Fonseca, Eduardo

doi:10.1111/j.1600-0536.2009.01596.x

Cited by 23 publications

(5 citation statements)

References 12 publications

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“…Actually, etofenamate is now considered as one of the most frequent causative agents of photoallergic dermatitis among NSAIDs. Diclofenac may also cause photoallergic dermatitis with cross-reaction to its prodrug aceclofenac [45 ]. Diclofenac photodecomposes to give a chlorocarbazole, and, in a subsequent step, dehalogenation is produced, as discussed above for carprofen.…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 96%

Generation of reactive intermediates in photoallergic dermatitis

Andreu

Mayorga

Miranda

2010

Current Opinion in Allergy &Amp; Clinical Immunology

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In the current review, some specific examples of photoallergic xenobiotics are given. They include nonsteroidal anti-inflammatory drugs, antibiotics, platelet aggregation inhibitors, and sunscreens. In general, they are taken from the scientific literature published during the last decade, with particular emphasis on the most recent articles. The focus is on the mechanistic aspects, specifically on the generation of reactive intermediates capable of reacting with proteins.

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Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 96%

Generation of reactive intermediates in photoallergic dermatitis

Andreu

Mayorga

Miranda

2010

Current Opinion in Allergy &Amp; Clinical Immunology

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“…The most positive reactions to etofenamate in EMCPPTS were found to have limited clinical relevance, thus raising the question of phototoxicity rather than photoallergy (28). Other NSAIDs are reported to cause photoallergy like piroxicam, benzydamine, diclofenac, and others, and some are listed in Tables 3 and 4 (43,68,76,(104)(105)(106)(107)(108)(109)(110)(111)(112).…”

Section: Topical Nsaidsmentioning

confidence: 98%

Photoallergy

Honari¹

2014

Reviews on Environmental Health

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“…Benzophenone plays a major role in ketoprofen photosensitive effects [ 107 ] and cross-reactions have been described for tiaprofenic acid, suprofen, oxybenzone, and fenofibrate [ 11 , 107 , 108 ]. A cross-reactivity in photoallergic sensitization has also been described between diclofenac and aceclofenac, both responsible for vesicular dermatitis [ 11 , 107 , 109 , 110 ].…”

Section: Photosensitive Drugsmentioning

confidence: 99%

Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations

et al. 2020

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Photosensitivity induced by drugs is a widely experienced problem, concerning both molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent one of the most common drug adverse events and are frequently an important issue to consider in the therapeutic management of patients. Phototoxicity and photoallergy are the two different pathogenic mechanisms involved in photosensitization. Related cutaneous manifestations are heterogeneous, depending on the culprit drug and subject susceptibility. Here we report an updated review of the literature with respect to pathogenic mechanisms of photosensitivity, clinical manifestations, patient management, and prediction and evaluation of drug-induced photosensitivity. We present and discuss principal groups of photosensitizing drugs (antimicrobials, nonsteroidal anti-inflammatory drugs, anti-hypertensives, anti-arrhythmics, cholesterol, and glycemia-lowering agents, psychotropic drugs, chemotherapeutics, etc.) and their main damage mechanisms according to recent evidence. The link between the drug and the cutaneous manifestation is not always clear; more investigations would be helpful to better predict drug photosensitizing potential, prevent and manage cutaneous adverse events and find the most appropriate alternative therapeutic strategy.

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Photoallergic contact dermatitis due to diclofenac with cross‐reaction to aceclofenac: two case reports

Cited by 23 publications

References 12 publications

Generation of reactive intermediates in photoallergic dermatitis

Generation of reactive intermediates in photoallergic dermatitis

Photoallergy

Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations

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