Photobiomodulation in the Treatment of Muscle Injury: A Systematic Review

Teles, Ramon Handerson Gomes; Dutra, Yago Medeiros; Vale, Donária Bezerra Nobre do; Santos, Thiago Pereira dos; Neto, José Carlos Raposo Mazulo; Brito, Tarcísio Vieira de; Costa, Mariana de Souza; Oliveira, Saul Barbosa de; Brauna, Isabela de Souza; Silva, Felipe Rodolfo Pereira da; Filgueiras, Marcelo de Carvalho

doi:10.1615/critrevphysrehabilmed.2018024861

Cited by 3 publications

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“…To this end, positive results have been obtained in clinical ( 9 ) and animal ( 10 , 11 ) trials. Consequently, PBM therapy (PBMT) has seen significant interest as a form of treatment in sports-related injuries ( 12 – 15 ) and has been studied in connection with sports performance ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro

Staelens

Gregorio

Kalra

et al. 2022

Front. Med. Technol.

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We report the results of experimental investigations involving photobiomodulation (PBM) of living cells, tubulin, and microtubules in buffer solutions exposed to near-infrared (NIR) light emitted from an 810 nm LED with a power density of 25 mW/cm2 pulsed at a frequency of 10 Hz. In the first group of experiments, we measured changes in the alternating current (AC) ionic conductivity in the 50–100 kHz range of HeLa and U251 cancer cell lines as living cells exposed to PBM for 60 min, and an increased resistance compared to the control cells was observed. In the second group of experiments, we investigated the stability and polymerization of microtubules under exposure to PBM. The protein buffer solution used was a mixture of Britton-Robinson buffer (BRB aka PEM) and microtubule cushion buffer. Exposure of Taxol-stabilized microtubules (~2 μM tubulin) to the LED for 120 min resulted in gradual disassembly of microtubules observed in fluorescence microscopy images. These results were compared to controls where microtubules remained stable. In the third group of experiments, we performed turbidity measurements throughout the tubulin polymerization process to quantify the rate and amount of polymerization for PBM-exposed tubulin vs. unexposed tubulin samples, using tubulin resuspended to final concentrations of ~ 22.7 μM and ~ 45.5 μM in the same buffer solution as before. Compared to the unexposed control samples, absorbance measurement results demonstrated a slower rate and reduced overall amount of polymerization in the less concentrated tubulin samples exposed to PBM for 30 min with the parameters mentioned above. Paradoxically, the opposite effect was observed in the 45.5 μM tubulin samples, demonstrating a remarkable increase in the polymerization rates and total polymer mass achieved after exposure to PBM. These results on the effects of PBM on living cells, tubulin, and microtubules are novel, further validating the modulating effects of PBM and contributing to designing more effective PBM parameters. Finally, potential consequences for the use of PBM in the context of neurodegenerative diseases are discussed.

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Section: Introductionmentioning

confidence: 99%

Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro

Staelens

Gregorio

Kalra

et al. 2022

Front. Med. Technol.

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Effects of photobiomodulation therapy on regulation of myogenic regulatory factor mRNA expression in vivo: A systematic review

Shepherd

Norris

Simpson

et al. 2021

Journal of Biophotonics

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Non‐invasive promotion of myogenic regulatory factors (MRFs), through photobiomodulation therapy (PBMT), may be a viable method of facilitating skeletal muscle regeneration post‐injury, given the importance of MRF in skeletal muscle regeneration. The aim of this systematic review was to collate current evidence, identifying key themes and changes in expression of MRF in in vivo models. Web of Science, PubMed, Scopus and Cochrane databases were systematically searched and identified 1459 studies, of which 10 met the inclusion criteria. Myogenic determination factor was most consistently regulated in response to PBMT treatment, and the expression of remaining MRFs was heterogenous. All studies exhibited a high risk of bias, primarily due to lack of blinding in PBMT application and MRF analysis. Our review suggests that the current evidence base for MRF expression from PBMT is highly variable. Future research should focus on developing a robust methodology for determining the effect of laser therapy on MRF expression, as well as long‐term assessment of skeletal muscle regeneration.

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Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview

Najm,

Moldoveanu,

Niculescu

et al. 2024

IJMS

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Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it is a public health problem that requires attention from researchers. This review aims to highlight drug delivery systems that have a high and efficient therapeutic potential for sarcopenia. Current as well as future research needs to consider the barriers encountered in the realization of delivery systems, such as the route of administration, the interaction of the systems with the aggressive environment of the human body, the efficient delivery and loading of the systems with therapeutic agents, and the targeted delivery of therapeutic agents into the muscle tissue without creating undesirable adverse effects. Thus, this paper sets the framework of existing drug delivery possibilities for the treatment of sarcopenia, serving as an inception point for future interdisciplinary studies.

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Photobiomodulation in the Treatment of Muscle Injury: A Systematic Review

Cited by 3 publications

References 0 publications

Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro

Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro

Effects of photobiomodulation therapy on regulation of myogenic regulatory factor mRNA expression in vivo: A systematic review

Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview

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