Photobiomodulation therapy as a high potential treatment modality for COVID-19

Soheilifar, Sepideh; Fathi, Homa; Naghdi, Navid

doi:10.1007/s10103-020-03206-9

Cited by 28 publications

(21 citation statements)

References 28 publications

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“…Photobiomodulation (PBM) represents a new and emerging therapeutic modality for the treatment of coronavirus[ 1 ], [ 2 ] (including COVID‐19) and related inflammatory diseases such as pneumonia,[ 3 ], [ 4 ], [ 5 ] acute respiratory distress syndrome (ARDS),[ 6 ], [ 7 ], [ 8 ] chronic obstructive pulmonary disease (COPD)[ 9 ] and acute lung injury[ 10 ]. In PBM therapy, diseased or injured tissue is illuminated by a source of nonionizing electromagnetic radiation or EMR (delivered via lasers or LEDs) to stimulate physiologically beneficial photochemical reactions.…”

Section: Introductionmentioning

confidence: 99%

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Williams

Raimondo²,

Cahn

et al. 2021

Journal of Biophotonics

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A nonrandomized 50‐person case study of COVID‐19‐positive patients was conducted employing (for the first time) a regimen of whole‐organ deep‐tissue transdermal dynamic photobiomodulation (PBM) as a primary (or exclusive) therapeutic modality in the treatment of coronavirus. Therapy sessions comprised algorithmically alternating red (650 nm) and near‐infrared (NIR; 850 nm) LEDs with an average irradiance of 11 mW/cm 2 dynamically sequenced at multiple pulse frequencies. Delivered via 3D bendable polymeric pads maintaining orthogonal optical incidence to body contours over 1,000 cm 2 , a single 84‐minute session concurrently delivered 20 kJ to the sinuses and 15 kJ to each lung at skin temperatures below 42°C. Therapeutic outcomes observed include significant reductions in the duration and severity of disease symptoms. Acute conditions including fever, body aches (BA) and respiratory distress comprising paroxysmal coughing; lung congestion, dyspnea and hypoxia; sinus congestion; acute eye inflammation; and extreme malaise were eliminated in 41/50 patients within 4 days of commencing PBM treatments with 50/50 patients fully recovering within 3 weeks with no supplemental oxygen requirements. SpO 2 concentrations improved as much as 9 points (average 2.5 points) across the entire study population. The PBM sessions required to completely resolve COVID‐19 conditions appears monotonically correlated to the time‐to‐treatment (TTTx)—the delay between the onset of a patient's symptoms and commencing PBM therapy. In contrast, acute inflammatory symptoms were resolved within 4 days irrespective of TTTx.

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Section: Introductionmentioning

confidence: 99%

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Williams

Raimondo²,

Cahn

et al. 2021

Journal of Biophotonics

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“…In this context, combined phototherapy approaches have been used to manage these COVID-19-related oral lesions [ 74 , 75 ]. The use of photobiomodulation has been claimed even in severe cases of acute respiratory distress syndrome in COVID-19 infected patients [76] . Clinical outcomes related to the application of photobiomodulation have shown successfully healing of oral lesions after few days [ 74 , 75 ].…”

Section: Biophotonics Approachesmentioning

confidence: 99%

“…These benefits appear to be related on the photobiomodulation's capacity to reduce or inhibit important substances involved in pain and inflammatory processes [74] , leading to an enhanced healing and improved quality of life for patients. A recent systematic review reported that photobiomodulation can significantly decrease the production of pro-inflammatory cytokines and some interleukins, reducing inflammation processes, regenerating damaged tissues [77] , and balancing the immune system [76] .…”

Section: Biophotonics Approachesmentioning

confidence: 99%

How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?

Besegato

Melo

Tamae

et al. 2022

Photodiagnosis and Photodynamic Therapy

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Biophotonics is defined as the combination of biology and photonics (the physical science of the light). It is a general term for all techniques that deal with the interaction between biological tissues/cells and photons (light). Biophotonics offers a great variety of techniques that can facilitate the early detection of diseases and promote innovative theragnostic approaches. As the COVID-19 infection can be transmitted due to the face-to-face communication, droplets and aerosol inhalation and the exposure to saliva, blood, and other body fluids, as well as the handling of sharp instruments, dental practices are at increased risk of infection. In this paper, a literature review was performed to explore the application of Biophotonics approaches in Dentistry focusing on the COVID-19 pandemic and how they can contribute to avoid or minimize the risks of infection in a dental setting. For this, search-related papers were retrieved from PubMED, Scielo, Google Schoolar, and American Dental Association and Centers for Disease Control and Prevention databases. The body of evidence currently available showed that Biophotonics approaches can reduce microorganism load, decontaminate surfaces, air, tissues, and minimize the generation of aerosol and virus spreading by minimally invasive, time-saving, and alternative techniques in general. However, each clinical situation must be individually evaluated regarding the benefits and drawbacks of these approaches, but always pursuing less-invasive and less aerosol-generating procedures, especially during the COVID-19 pandemic.

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“…PBM stabilize the function of the immune system (drop the level of pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, TNFα, and MCP-1 and improve the balance of IL-10) in severe COVID-19 cases, decreasing the impact of cytokine storm as the main cause of high mortality in ARDS patients [ 300 ].…”

Section: Photobiomodulation and Covid-19mentioning

confidence: 99%

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Ailioaie

Litscher

2021

IJMS

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In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut–lung–brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body.

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Photobiomodulation therapy as a high potential treatment modality for COVID-19

Cited by 28 publications

References 28 publications

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

Whole‐organ transdermal photobiomodulation (PBM) of COVID‐19: A 50‐patient case study

How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

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