Photobiomodulation therapy in diabetic wound healing

Ponnusamy, Sasikumar; Mosca, Rodrigo Crespo; Desai, Karishma Madhusudan; Arany, Praveen

doi:10.1016/b978-0-12-816413-6.00015-0

Cited by 2 publications

(7 citation statements)

References 88 publications

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“…PBM uses low-intensity light over the injury site to reduce pain and inflammation and activate tissue repair [8]. It is a low-risk, non-invasive, pain-free, and cost-effective medical therapy for the effective management of conditions, such as non-healing chronic wounds [34,84].…”

Section: Photobiomodulation (Pbm)mentioning

confidence: 99%

“…Mosca et al [85] revealed that the action of COX generates intracellular ROS and leads to the accumulation of cyclic AMP (cAMP) [93]. The activity of COX is inhibited when nitric oxide (NO) binds to its oxidized or reduced binuclear sites [8]. PBM stimulates the disassociation of NO from COX, therefore reversing the inhibition of NO on COX binding sites, leading to changes in oxidative stress on the mitochondrial membrane [8,18].…”

Section: Cellular and Molecular Mechanism Of Action Of Pbmmentioning

confidence: 99%

“…The activity of COX is inhibited when nitric oxide (NO) binds to its oxidized or reduced binuclear sites [8]. PBM stimulates the disassociation of NO from COX, therefore reversing the inhibition of NO on COX binding sites, leading to changes in oxidative stress on the mitochondrial membrane [8,18]. These processes activate a cascade of cellular events, leading to physiological changes in cellular signalling, gene transcription, and downstream protein synthesis for cell proliferation, differentiation, and migration [85,94].…”

Section: Cellular and Molecular Mechanism Of Action Of Pbmmentioning

confidence: 99%

“…Photobiomodulation (PBM), previously known as low-level laser therapy (LLLT), is defined as the application of non-ionising radiation in the form of light with the intent to heal. PBM employs the use of photons at a non-thermal irradiance to elicit photochemical and photophysical events to alter biological activity [7,8]. These non-ionising light sources can either be coherent light (lasers) or non-coherent light (broadband light sources and light-emitting diodes-LEDs), typically in the visible red or near-infrared (NIR) spectrum [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…PBM employs the use of photons at a non-thermal irradiance to elicit photochemical and photophysical events to alter biological activity [7,8]. These non-ionising light sources can either be coherent light (lasers) or non-coherent light (broadband light sources and light-emitting diodes-LEDs), typically in the visible red or near-infrared (NIR) spectrum [7,8]. PBM is devoid of thermal and ablative mechanisms and exploits the absorption of light to affect a chemical change [9].…”

Section: Introductionmentioning

confidence: 99%

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Cellular Signalling and Photobiomodulation in Chronic Wound Repair

Leyane

Jere

Houreld

2021

IJMS

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Photobiomodulation (PBM) imparts therapeutically significant benefits in the healing of chronic wounds. Chronic wounds develop when the stages of wound healing fail to progress in a timely and orderly frame, and without an established functional and structural outcome. Therapeutic benefits associated with PBM include augmenting tissue regeneration and repair, mitigating inflammation, relieving pain, and reducing oxidative stress. PBM stimulates the mitochondria, resulting in an increase in adenosine triphosphate (ATP) production and the downstream release of growth factors. The binding of growth factors to cell surface receptors induces signalling pathways that transmit signals to the nucleus for the transcription of genes for increased cellular proliferation, viability, and migration in numerous cell types, including stem cells and fibroblasts. Over the past few years, significant advances have been made in understanding how PBM regulates numerous signalling pathways implicated in chronic wound repair. This review highlights the significant role of PBM in the activation of several cell signalling pathways involved in wound healing.

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Section: Photobiomodulation (Pbm)mentioning

confidence: 99%

Section: Cellular and Molecular Mechanism Of Action Of Pbmmentioning

confidence: 99%

Section: Cellular and Molecular Mechanism Of Action Of Pbmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cellular Signalling and Photobiomodulation in Chronic Wound Repair

Leyane

Jere

Houreld

2021

IJMS

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Rationale for Discrete Light Treatment Approaches in Wound Care

Varsani,

Oliveira,

Crespo Mosca

et al. 2024

Pearls in Biological and Molecular Tissue Repair Pathways

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Wound healing is a multifaceted and sequential process influenced by both local and systemic conditions. Chronic wounds can lead to functional impairments, persistent pain, and reduced quality of life posing a significant burden on the healthcare system. In the US, approximately 6.5 million patients suffer from chronic wounds annually, costing the healthcare system over $25 billion. Given these substantial costs, there is an urgent need for innovative and effective wound management approaches. Historically, light therapy has been utilized to treat various skin diseases. There has been tremendous recent progress in light treatment approaches. This chapter outlines the fundamentals of wound healing and examines how different types of light can modulate specific stages of wound healing. These treatments can be broadly categorized based on their biological tissue interactions as photothermal therapy (PTT), photodynamic therapy (PDT), and photobiomodulation (PBM). Each treatment has a discrete mechanism of action evoking directed biological responses to promote wound healing. Additionally, appreciating the fundamental premise of each approach enables rationalized combinations for optimal therapeutic clinical benefits. Light treatments offer an additional innovative approach to effective wound management.

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Photobiomodulation therapy in diabetic wound healing

Cited by 2 publications

References 88 publications

Cellular Signalling and Photobiomodulation in Chronic Wound Repair

Cellular Signalling and Photobiomodulation in Chronic Wound Repair

Rationale for Discrete Light Treatment Approaches in Wound Care

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