“…In addition, surface preparation and modification techniques (26)(27)(28)77) have also allowed for analyte selectivity. As such, investigators have applied SERS to many analytical systems in recent years, including anthrax detection (29,77), chemical warfare-stimulant detection (17), in vitro (6,30,79) and in vivo (78) glucose sensing, environmental monitoring (18), the monitoring of heterogeneous catalytic reactions (19), and explosive-agent detection (20). The need for new SERS-based sensing, detecting, and monitoring platforms has also driven new instrumental techniques such as the integration of SERS active substrates into fiber-optic assemblies (18).…”